RPF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPF1_HUMAN
• UniProt AC: Q9H9Y2
• Protein Name: Ribosome production factor 1
• Gene Name: RPF1
• Organism: Homo sapiens (Human).
• Sequence Length: 349
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: May be required for ribosome biogenesis..
• Protein Sequence: MAKAGDKSSSSGKKSLKRKAAAEELQEAAGAGDGATENGVQPPKAAAFPPGFSISEIKNKQRRHLMFTRWKQQQRKEKLAAKKKLKKEREALGDKAPPKPVPKTIDNQRVYDETTVDPNDEEVAYDEATDEFASYFNKQTSPKILITTSDRPHGRTVRLCEQLSTVIPNSHVYYRRGLALKKIIPQCIARDFTDLIVINEDRKTPNGLILSHLPNGPTAHFKMSSVRLRKEIKRRGKDPTEHIPEIILNNFTTRLGHSIGRMFASLFPHNPQFIGRQVATFHNQRDYIFFRFHRYIFRSEKKVGIQELGPRFTLKLRSLQKGTFDSKYGEYEWVHKPREMDTSRRKFHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MAKAGDKSSS -----CCCCCCCCCC	52.16	23503661
3	Acetylation	-----MAKAGDKSSS -----CCCCCCCCCC	52.16	7681963
7	Ubiquitination	-MAKAGDKSSSSGKK -CCCCCCCCCCCCHH	51.85	24816145
8	Phosphorylation	MAKAGDKSSSSGKKS CCCCCCCCCCCCHHH	39.94	29978859
9	Phosphorylation	AKAGDKSSSSGKKSL CCCCCCCCCCCHHHH	33.97	29978859
10	Phosphorylation	KAGDKSSSSGKKSLK CCCCCCCCCCHHHHH	50.64	29978859
11	Phosphorylation	AGDKSSSSGKKSLKR CCCCCCCCCHHHHHH	57.49	29978859
13	Acetylation	DKSSSSGKKSLKRKA CCCCCCCHHHHHHHH	40.93	7681973
13	Ubiquitination	DKSSSSGKKSLKRKA CCCCCCCHHHHHHHH	40.93	23503661
68	O-linked_Glycosylation	QRRHLMFTRWKQQQR HHHHHHHHHHHHHHH	22.96	30379171
82	Ubiquitination	RKEKLAAKKKLKKER HHHHHHHHHHHHHHH	44.85	23503661
83	Ubiquitination	KEKLAAKKKLKKERE HHHHHHHHHHHHHHH	59.62	23503661
84	Ubiquitination	EKLAAKKKLKKEREA HHHHHHHHHHHHHHH	65.90	23503661
86	Ubiquitination	LAAKKKLKKEREALG HHHHHHHHHHHHHHC	62.56	23503661
87	Ubiquitination	AAKKKLKKEREALGD HHHHHHHHHHHHHCC	72.88	23503661
95	Ubiquitination	EREALGDKAPPKPVP HHHHHCCCCCCCCCC	62.08	23503661
99	Ubiquitination	LGDKAPPKPVPKTID HCCCCCCCCCCCCCC	58.55	23503661
103	Ubiquitination	APPKPVPKTIDNQRV CCCCCCCCCCCCCEE	59.34	29967540
138	Ubiquitination	EFASYFNKQTSPKIL HHHHHHCCCCCCCEE	45.08	21963094
143	Ubiquitination	FNKQTSPKILITTSD HCCCCCCCEEEECCC	50.33	22817900
170	Phosphorylation	LSTVIPNSHVYYRRG HHCCCCCCHHHHCCC	14.69	28152594
173	Phosphorylation	VIPNSHVYYRRGLAL CCCCCHHHHCCCHHH	5.94	28152594
174	Phosphorylation	IPNSHVYYRRGLALK CCCCHHHHCCCHHHH	7.86	28152594
181	Ubiquitination	YRRGLALKKIIPQCI HCCCHHHHHHHHHHH	36.00	23000965
182	Ubiquitination	RRGLALKKIIPQCIA CCCHHHHHHHHHHHH	46.87	23000965
233	Acetylation	VRLRKEIKRRGKDPT HHHHHHHHHCCCCCC	36.81	11921517
237	Ubiquitination	KEIKRRGKDPTEHIP HHHHHCCCCCCCCCC	59.74	33845483
237	Acetylation	KEIKRRGKDPTEHIP HHHHHCCCCCCCCCC	59.74	26051181
240	Phosphorylation	KRRGKDPTEHIPEII HHCCCCCCCCCCHHH	50.78	20860994
287	Phosphorylation	TFHNQRDYIFFRFHR EECCCCCEEEEEECH	11.21	20393185
302	Ubiquitination	YIFRSEKKVGIQELG HHHCCCCCCCCEECC	41.46	29967540
311	Methylation	GIQELGPRFTLKLRS CCEECCCCEEEEEEE	35.07	-
321	Ubiquitination	LKLRSLQKGTFDSKY EEEEECCCCCCCCCC	66.27	29967540
327	Ubiquitination	QKGTFDSKYGEYEWV CCCCCCCCCCCEEEE	60.15	29967540
331	Phosphorylation	FDSKYGEYEWVHKPR CCCCCCCEEEECCCC	15.66	-
336	Ubiquitination	GEYEWVHKPREMDTS CCEEEECCCCCCCCC	35.83	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956
PUM3_HUMAN	KIAA0020	physical	26344197
RPF2_HUMAN	RPF2	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
MAK16_HUMAN	MAK16	physical	28514442
Z324A_HUMAN	ZNF324	physical	28514442
WDR74_HUMAN	WDR74	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
ZN460_HUMAN	ZNF460	physical	28514442
ZN689_HUMAN	ZNF689	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
ZBT11_HUMAN	ZBTB11	physical	28514442
RS16_HUMAN	RPS16	physical	28514442
SART3_HUMAN	SART3	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
RS6_HUMAN	RPS6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.