dbPTM

ZBT11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZBT11_HUMAN
UniProt AC	O95625
Protein Name	Zinc finger and BTB domain-containing protein 11
Gene Name	ZBTB11
Organism	Homo sapiens (Human).
Sequence Length	1053
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MSSEESYRAILRYLTNEREPYAPGTEGNVKRKIRKAAACYVVRGGTLYYQRRQRHRKTFAELEVVLQPERRRDLIEAAHLGPGGTHHTRHQTWHYLSKTYWWRGILKQVKDYIKQCSKCQEKLDRSRPISDVSEMLEELGLDLESGEESNESEDDLSNFTSSPTTASKPAKKKPVSKHELVFVDTKGVVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLMEEKQLTVYKKGEVQTVASTQDLRVQNGGTAPPVASSEGTTTSLPTELGDCEIVLLVNGELPEAEQNGEVGRQPEPQVSSEAESALSSVGCIADSHPEMESVDLITKNNQTELETSNNRENNTVSNIHPKLSKENVISSSPEDSGMGNDISAEDICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTYRSRLRQRSVNEGAYIRLHKGMEKKLQKRKAVPKSAVQQVAQKLVQRGKKMKQPKRDAKENTEEASHKCGECGMVFQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASGTSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQKQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHFKKHQPKPEVRGYHCTQCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEKALFRRHVKKATHGKKGRAKQNLERVCEKCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHAVSILTAGMQEQESSGPQELETVVVTGETMEALEAVAATEEYPSVSTLSDQSIMQVVNYVLAQQQGQKLSEVAEAIQTVKVEVAHISGGE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SYRAILRYLTNEREP HHHHHHHHHHCCCCC	17.90	27251275
15	Phosphorylation	RAILRYLTNEREPYA HHHHHHHHCCCCCCC	26.54	27251275
30	Ubiquitination	PGTEGNVKRKIRKAA CCCCCCHHHHHHHHH	52.56	21906983
98	Acetylation	QTWHYLSKTYWWRGI HHHHHHCHHHHHHHH	42.93	12655513
110	Ubiquitination	RGILKQVKDYIKQCS HHHHHHHHHHHHHHH	42.17	-
114	Ubiquitination	KQVKDYIKQCSKCQE HHHHHHHHHHHHHHH	38.74	-
126	Phosphorylation	CQEKLDRSRPISDVS HHHHHHCCCCCCHHH	41.92	17081983
130	Phosphorylation	LDRSRPISDVSEMLE HHCCCCCCHHHHHHH	34.34	17081983
133	Phosphorylation	SRPISDVSEMLEELG CCCCCHHHHHHHHCC	23.44	17081983
145	Phosphorylation	ELGLDLESGEESNES HCCCCCCCCCCCCCC	59.82	22817900
149	Phosphorylation	DLESGEESNESEDDL CCCCCCCCCCCCCHH	41.41	22817900
152	Phosphorylation	SGEESNESEDDLSNF CCCCCCCCCCHHCCC	51.04	22817900
157	Phosphorylation	NESEDDLSNFTSSPT CCCCCHHCCCCCCCC	36.57	17081983
160	Phosphorylation	EDDLSNFTSSPTTAS CCHHCCCCCCCCCCC	32.33	17081983
161	Phosphorylation	DDLSNFTSSPTTASK CHHCCCCCCCCCCCC	30.13	17081983
162	Phosphorylation	DLSNFTSSPTTASKP HHCCCCCCCCCCCCC	24.17	17081983
165	Phosphorylation	NFTSSPTTASKPAKK CCCCCCCCCCCCCCC	32.11	17081983
167	Phosphorylation	TSSPTTASKPAKKKP CCCCCCCCCCCCCCC	36.76	17081983
186	Ubiquitination	ELVFVDTKGVVKRSS CEEEECCCCCCCCCC	45.29	-
186	Sumoylation	ELVFVDTKGVVKRSS CEEEECCCCCCCCCC	45.29	-
186	Sumoylation	ELVFVDTKGVVKRSS CEEEECCCCCCCCCC	45.29	-
192	Phosphorylation	TKGVVKRSSPKHCQA CCCCCCCCCHHHHHH	45.32	-
193	Phosphorylation	KGVVKRSSPKHCQAV CCCCCCCCHHHHHHH	41.84	-
195	Ubiquitination	VVKRSSPKHCQAVLK CCCCCCHHHHHHHHH	59.98	-
202	Ubiquitination	KHCQAVLKQLNEQRL HHHHHHHHHHHHHHH	46.25	-
229	Ubiquitination	GEEYKAHKSVLSANS CCHHHHCHHHHHCCC	47.31	-
230	Phosphorylation	EEYKAHKSVLSANSE CHHHHCHHHHHCCCH	20.58	21406692
233	Phosphorylation	KAHKSVLSANSEYFR HHCHHHHHCCCHHHH	24.21	21406692
236	Phosphorylation	KSVLSANSEYFRDLF HHHHHCCCHHHHHHH	33.13	21406692
238	Phosphorylation	VLSANSEYFRDLFIE HHHCCCHHHHHHHHH	12.07	21406692
246	Ubiquitination	FRDLFIEKGAVSSHE HHHHHHHCCCCCCCC	47.56	-
314	Ubiquitination	VHKLMEEKQLTVYKK HHHHHHHCCEEEEEC	36.98	-
317	Phosphorylation	LMEEKQLTVYKKGEV HHHHCCEEEEECCEE	21.21	23532336
319	Phosphorylation	EEKQLTVYKKGEVQT HHCCEEEEECCEEEE	11.18	28102081
321	Ubiquitination	KQLTVYKKGEVQTVA CCEEEEECCEEEEEE	42.49	-
329	Phosphorylation	GEVQTVASTQDLRVQ CEEEEEEECCCEEEC	23.43	-
334	Methylation	VASTQDLRVQNGGTA EEECCCEEECCCCCC	35.94	24411709
334	Dimethylation	VASTQDLRVQNGGTA EEECCCEEECCCCCC	35.94	-
426	Phosphorylation	NQTELETSNNRENNT CCCEEECCCCCCCCC	23.80	29214152
433	Phosphorylation	SNNRENNTVSNIHPK CCCCCCCCCCCCCHH	36.57	28555341
442	Phosphorylation	SNIHPKLSKENVISS CCCCHHCCCCCCCCC	44.01	30576142
448	Phosphorylation	LSKENVISSSPEDSG CCCCCCCCCCCCCCC	22.08	28102081
449	Phosphorylation	SKENVISSSPEDSGM CCCCCCCCCCCCCCC	38.50	25159151
450	Phosphorylation	KENVISSSPEDSGMG CCCCCCCCCCCCCCC	26.05	28102081
454	Phosphorylation	ISSSPEDSGMGNDIS CCCCCCCCCCCCCCC	29.08	23663014
461	Phosphorylation	SGMGNDISAEDICAE CCCCCCCCHHHHCHH	28.59	23663014
482	Acetylation	QKVDQPLKDQENLVA HHCCCCCCCCHHHHH	65.14	26051181
482	Ubiquitination	QKVDQPLKDQENLVA HHCCCCCCCCHHHHH	65.14	-
493	Ubiquitination	NLVASTAKTDFGPDD HHHHHHCCCCCCCCC	49.03	-
511	Phosphorylation	RSRLRQRSVNEGAYI HHHHHHCCCCCCHHH	22.43	25159151
517	Phosphorylation	RSVNEGAYIRLHKGM CCCCCCHHHHHCCHH	9.46	17360941
537	Phosphorylation	KRKAVPKSAVQQVAQ HCCCCCHHHHHHHHH	27.83	-
545	Acetylation	AVQQVAQKLVQRGKK HHHHHHHHHHHCCHH	40.67	25953088
609	Phosphorylation	CKKQFQYSASLRAHL HHHHHCCCHHHHHHH	10.70	24719451
611	Phosphorylation	KQFQYSASLRAHLIR HHHCCCHHHHHHHHH	16.67	24719451
620	O-linked_Glycosylation	RAHLIRHTRKDAPSS HHHHHHHCCCCCCCC	29.57	30620550
626	Phosphorylation	HTRKDAPSSSSSNST HCCCCCCCCCCCCCC	44.57	30576142
627	Phosphorylation	TRKDAPSSSSSNSTS CCCCCCCCCCCCCCC	32.93	30576142
629	Phosphorylation	KDAPSSSSSNSTSNE CCCCCCCCCCCCCCC	35.17	30576142
630	Phosphorylation	DAPSSSSSNSTSNEA CCCCCCCCCCCCCCC	36.43	30576142
632	Phosphorylation	PSSSSSNSTSNEASG CCCCCCCCCCCCCCC	34.85	30576142
633	Phosphorylation	SSSSSNSTSNEASGT CCCCCCCCCCCCCCC	39.56	30576142
640	Phosphorylation	TSNEASGTSSEKGRT CCCCCCCCCCCCCCC	26.95	30576142
642	Phosphorylation	NEASGTSSEKGRTKR CCCCCCCCCCCCCHH	43.07	30576142
665	Phosphorylation	RTLPKLYSLRIHMLK CCHHHHHHHHHHHHH	22.93	24719451
674	Phosphorylation	RIHMLKHTGVKPHAC HHHHHHHCCCCHHHC	41.92	-
687	Phosphorylation	ACQVCGKTFIYKHGL HCCCCCCCHHHHHCH	10.68	29083192
690	Phosphorylation	VCGKTFIYKHGLKLH CCCCCHHHHHCHHHH	7.85	29083192
699	Phosphorylation	HGLKLHQSLHQSQKQ HCHHHHHHHHHHHHH	19.64	29083192
703	Phosphorylation	LHQSLHQSQKQFQCE HHHHHHHHHHHHCHH	28.70	29083192
721	Phosphorylation	KSFVTKRSLQEHMSI HHHHCHHHHHHHHCC	35.64	25137130
727	Phosphorylation	RSLQEHMSIHTGESK HHHHHHHCCCCCCCH	17.08	25137130
730	Phosphorylation	QEHMSIHTGESKYLC HHHHCCCCCCCHHHH	40.76	29978859
733	Phosphorylation	MSIHTGESKYLCSVC HCCCCCCCHHHHCCC	28.13	29978859
743	Phosphorylation	LCSVCGKSFHRGSGL HHCCCCCCCCCCCCH	16.15	25137130
746	Methylation	VCGKSFHRGSGLSKH CCCCCCCCCCCHHHH	38.67	115920301
748	O-linked_Glycosylation	GKSFHRGSGLSKHFK CCCCCCCCCHHHHHH	36.20	30620550
751	O-linked_Glycosylation	FHRGSGLSKHFKKHQ CCCCCCHHHHHHHCC	27.84	30620550
773	Ubiquitination	YHCTQCEKSFFEARD CCCCHHCHHHHHHHH	61.25	-
792	Ubiquitination	MNKHLGVKPFQCQFC HHHHCCCCCEECCCC	38.01	-
792	Acetylation	MNKHLGVKPFQCQFC HHHHCCCCCEECCCC	38.01	26051181
815	Phosphorylation	DWYSHVKSHSVTEPY HHHHCCHHCCCCCCE	21.65	29396449
817	Phosphorylation	YSHVKSHSVTEPYRC HHCCHHCCCCCCEEC	37.51	29496963
819	Phosphorylation	HVKSHSVTEPYRCNI CCHHCCCCCCEECCC	33.97	22817900
834	Ubiquitination	CGKEFYEKALFRRHV CCHHHHHHHHHHHHH	38.72	-
909	Phosphorylation	KRHVRTHTGERPYVC HHHHHHCCCCCCEEC	39.87	21857030
944	Ubiquitination	HRDYVPCKIMLEKDT CCCCCCEEEEEECCC	25.69	-
1043	Ubiquitination	AEAIQTVKVEVAHIS HHHHHHCEEEEEECC	35.74	-
1043	Sumoylation	AEAIQTVKVEVAHIS HHHHHHCEEEEEECC	35.74	28112733
1050	Phosphorylation	KVEVAHISGGE---- EEEEEECCCCC----	30.77	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
511	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
537	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZBT11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZBT11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZBT11_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZBT11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1050, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1050, AND MASSSPECTROMETRY.	19007248 [Abstract]