RT22_HUMAN - dbPTM
RT22_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RT22_HUMAN
UniProt AC P82650
Protein Name 28S ribosomal protein S22, mitochondrial
Gene Name MRPS22
Organism Homo sapiens (Human).
Sequence Length 360
Subcellular Localization Mitochondrion .
Protein Description
Protein Sequence MAPLGTTVLLWSLLRSSPGVERVCFRARIQPWHGGLLQPLPCSFEMGLPRRRFSSEAAESGSPETKKPTFMDEEVQSILTKMTGLNLQKTFKPAIQELKPPTYKLMTQAQLEEATRQAVEAAKVRLKMPPVLEERVPINDVLAEDKILEGTETTKYVFTDISYSIPHRERFIVVREPSGTLRKASWEERDRMIQVYFPKEGRKILTPIIFKEENLRTMYSQDRHVDVLNLCFAQFEPDSTEYIKVHHKTYEDIDKRGKYDLLRSTRYFGGMVWYFVNNKKIDGLLIDQIQRDLIDDATNLVQLYHVLHPDGQSAQGAKDQAAEGINLIKVFAKTEAQKGAYIELTLQTYQEALSRHSAAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24UbiquitinationSPGVERVCFRARIQP
CCCCCEEEEEEECCC		2.0923503661
25UbiquitinationPGVERVCFRARIQPW
CCCCEEEEEEECCCC		6.6523503661
26UbiquitinationGVERVCFRARIQPWH
CCCEEEEEEECCCCC		20.1623503661
43PhosphorylationLLQPLPCSFEMGLPR
CCCCCCCCCCCCCCC		23.4624719451
54PhosphorylationGLPRRRFSSEAAESG
CCCCCCCCHHHHHCC		26.0026471730
55PhosphorylationLPRRRFSSEAAESGS
CCCCCCCHHHHHCCC		28.6626471730
57UbiquitinationRRRFSSEAAESGSPE
CCCCCHHHHHCCCCC		20.6222817900
58UbiquitinationRRFSSEAAESGSPET
CCCCHHHHHCCCCCC		13.8722817900
62PhosphorylationSEAAESGSPETKKPT
HHHHHCCCCCCCCCC		28.9221815630
62UbiquitinationSEAAESGSPETKKPT
HHHHHCCCCCCCCCC		28.9221890473
63UbiquitinationEAAESGSPETKKPTF
HHHHCCCCCCCCCCC		57.7221890473
65UbiquitinationAESGSPETKKPTFMD
HHCCCCCCCCCCCCH		47.9923503661
66UbiquitinationESGSPETKKPTFMDE
HCCCCCCCCCCCCHH		55.9123503661
67UbiquitinationSGSPETKKPTFMDEE
CCCCCCCCCCCCHHH		57.6223503661
69PhosphorylationSPETKKPTFMDEEVQ
CCCCCCCCCCHHHHH		40.2330619164
71SulfoxidationETKKPTFMDEEVQSI
CCCCCCCCHHHHHHH		7.5421406390
77PhosphorylationFMDEEVQSILTKMTG
CCHHHHHHHHHHHHC		25.4124719451
81UbiquitinationEVQSILTKMTGLNLQ
HHHHHHHHHHCCCCH		30.9022817900
82UbiquitinationVQSILTKMTGLNLQK
HHHHHHHHHCCCCHH		2.7922817900
85UbiquitinationILTKMTGLNLQKTFK
HHHHHHCCCCHHHCH		4.2022817900
86UbiquitinationLTKMTGLNLQKTFKP
HHHHHCCCCHHHCHH		41.5922817900
92UbiquitinationLNLQKTFKPAIQELK
CCCHHHCHHHHHHHC		38.4829967540
98UbiquitinationFKPAIQELKPPTYKL
CHHHHHHHCCCCHHH		6.0622817900
99UbiquitinationKPAIQELKPPTYKLM
HHHHHHHCCCCHHHC		48.4722817900
103UbiquitinationQELKPPTYKLMTQAQ
HHHCCCCHHHCCHHH		14.1121890473
103UbiquitinationQELKPPTYKLMTQAQ
HHHCCCCHHHCCHHH		14.1121890473
104UbiquitinationELKPPTYKLMTQAQL
HHCCCCHHHCCHHHH		33.9722817900
105UbiquitinationLKPPTYKLMTQAQLE
HCCCCHHHCCHHHHH		2.9422817900
106SulfoxidationKPPTYKLMTQAQLEE
CCCCHHHCCHHHHHH		1.9821406390
113UbiquitinationMTQAQLEEATRQAVE
CCHHHHHHHHHHHHH		65.0223503661
114UbiquitinationTQAQLEEATRQAVEA
CHHHHHHHHHHHHHH		9.9423503661
122UbiquitinationTRQAVEAAKVRLKMP
HHHHHHHHHHHHCCC		9.4322817900
123UbiquitinationRQAVEAAKVRLKMPP
HHHHHHHHHHHCCCC		34.6329967540
126UbiquitinationVEAAKVRLKMPPVLE
HHHHHHHHCCCCCHH		6.6222817900
127UbiquitinationEAAKVRLKMPPVLEE
HHHHHHHCCCCCHHC		38.5021906983
145UbiquitinationINDVLAEDKILEGTE
HHHHCCCCCCCCCCC		37.3722817900
146UbiquitinationNDVLAEDKILEGTET
HHHCCCCCCCCCCCC		40.4721906983
154UbiquitinationILEGTETTKYVFTDI
CCCCCCCEEEEEEEE		17.7223503661
155UbiquitinationLEGTETTKYVFTDIS
CCCCCCEEEEEEEEE		47.0023503661
156PhosphorylationEGTETTKYVFTDISY
CCCCCEEEEEEEEEC		9.9420068231
157UbiquitinationGTETTKYVFTDISYS
CCCCEEEEEEEEECC		4.4221890473
158UbiquitinationTETTKYVFTDISYSI
CCCEEEEEEEEECCC		4.6321890473
159PhosphorylationETTKYVFTDISYSIP
CCEEEEEEEEECCCC		23.5220068231
161UbiquitinationTKYVFTDISYSIPHR
EEEEEEEEECCCCCC		3.6522817900
162PhosphorylationKYVFTDISYSIPHRE
EEEEEEEECCCCCCC		18.6820068231
162UbiquitinationKYVFTDISYSIPHRE
EEEEEEEECCCCCCC		18.6822817900
163PhosphorylationYVFTDISYSIPHRER
EEEEEEECCCCCCCE		15.7920068231
164PhosphorylationVFTDISYSIPHRERF
EEEEEECCCCCCCEE		23.8920068231
169UbiquitinationSYSIPHRERFIVVRE
ECCCCCCCEEEEEEC		49.2422817900
170UbiquitinationYSIPHRERFIVVREP
CCCCCCCEEEEEECC		26.9222817900
178PhosphorylationFIVVREPSGTLRKAS
EEEEECCCCCCCCCC		39.3922210691
185PhosphorylationSGTLRKASWEERDRM
CCCCCCCCHHHHHCE		37.7522496350
196PhosphorylationRDRMIQVYFPKEGRK
HHCEEEEECCCCCCC		9.5921406692
198UbiquitinationRMIQVYFPKEGRKIL
CEEEEECCCCCCCCE		18.9921890473
199UbiquitinationMIQVYFPKEGRKILT
EEEEECCCCCCCCEE		64.0022817900
202UbiquitinationVYFPKEGRKILTPII
EECCCCCCCCEEEEE		24.7522817900
203UbiquitinationYFPKEGRKILTPIIF
ECCCCCCCCEEEEEE		53.5822817900
206PhosphorylationKEGRKILTPIIFKEE
CCCCCCEEEEEECHH		18.86-
210UbiquitinationKILTPIIFKEENLRT
CCEEEEEECHHHHHH		9.3722817900
211AcetylationILTPIIFKEENLRTM
CEEEEEECHHHHHHH		54.4319608861
211MalonylationILTPIIFKEENLRTM
CEEEEEECHHHHHHH		54.4326320211
211UbiquitinationILTPIIFKEENLRTM
CEEEEEECHHHHHHH		54.4322817900
244UbiquitinationPDSTEYIKVHHKTYE
CCCCCEEEEECCCHH		34.3129967540
244AcetylationPDSTEYIKVHHKTYE
CCCCCEEEEECCCHH		34.3125038526
248AcetylationEYIKVHHKTYEDIDK
CEEEEECCCHHHHHH		37.6125825284
248UbiquitinationEYIKVHHKTYEDIDK
CEEEEECCCHHHHHH		37.6129967540
248SuccinylationEYIKVHHKTYEDIDK
CEEEEECCCHHHHHH		37.6123954790
255SuccinylationKTYEDIDKRGKYDLL
CCHHHHHHCCCHHHH		64.4823954790
255AcetylationKTYEDIDKRGKYDLL
CCHHHHHHCCCHHHH		64.4825825284
255UbiquitinationKTYEDIDKRGKYDLL
CCHHHHHHCCCHHHH		64.4819608861
255MalonylationKTYEDIDKRGKYDLL
CCHHHHHHCCCHHHH		64.4826320211
258AcetylationEDIDKRGKYDLLRST
HHHHHCCCHHHHHCC		39.3625825284
258MalonylationEDIDKRGKYDLLRST
HHHHHCCCHHHHHCC		39.3626320211
264PhosphorylationGKYDLLRSTRYFGGM
CCHHHHHCCCCCCCE		19.7325921289
265PhosphorylationKYDLLRSTRYFGGMV
CHHHHHCCCCCCCEE		23.9725921289
274PhosphorylationYFGGMVWYFVNNKKI
CCCCEEEEEECCCEE		6.0425921289
280UbiquitinationWYFVNNKKIDGLLID
EEEECCCEECEEEHH		48.42-
2802-HydroxyisobutyrylationWYFVNNKKIDGLLID
EEEECCCEECEEEHH		48.42-
287UbiquitinationKIDGLLIDQIQRDLI
EECEEEHHHHHHHHH		39.2321890473
288UbiquitinationIDGLLIDQIQRDLID
ECEEEHHHHHHHHHH		27.0721890473
291UbiquitinationLLIDQIQRDLIDDAT
EEHHHHHHHHHHHHH		42.1922817900
292UbiquitinationLIDQIQRDLIDDATN
EHHHHHHHHHHHHHH		31.4422817900
311UbiquitinationYHVLHPDGQSAQGAK
HEEECCCCCCCCCCH		28.0021890473
315UbiquitinationHPDGQSAQGAKDQAA
CCCCCCCCCCHHHHH		58.5922817900
318UbiquitinationGQSAQGAKDQAAEGI
CCCCCCCHHHHHHHC		58.1429967540
328UbiquitinationAAEGINLIKVFAKTE
HHHHCCEEEEECCCH		2.8621890473
329UbiquitinationAEGINLIKVFAKTEA
HHHCCEEEEECCCHH		34.1721906983
329AcetylationAEGINLIKVFAKTEA
HHHCCEEEEECCCHH		34.1727452117
332UbiquitinationINLIKVFAKTEAQKG
CCEEEEECCCHHHCC		22.3522817900
333UbiquitinationNLIKVFAKTEAQKGA
CEEEEECCCHHHCCC		35.1222817900
333AcetylationNLIKVFAKTEAQKGA
CEEEEECCCHHHCCC		35.1225953088
349PhosphorylationIELTLQTYQEALSRH
EEEEHHHHHHHHHHH		7.4428348404
354PhosphorylationQTYQEALSRHSAAS-
HHHHHHHHHHHHCC-		34.6928348404
357PhosphorylationQEALSRHSAAS----
HHHHHHHHHCC----		25.1528348404
360PhosphorylationLSRHSAAS-------
HHHHHHCC-------		40.2328348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RT22_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RT22_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RT22_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RT25_HUMANMRPS25physical
22939629
RT35_HUMANMRPS35physical
22939629
RT26_HUMANMRPS26physical
22939629
SYQ_HUMANQARSphysical
22939629
T126A_HUMANTMEM126Aphysical
22939629
F192A_HUMANFAM192Aphysical
26344197
RT18B_HUMANMRPS18Bphysical
26344197
RT23_HUMANMRPS23physical
26344197
RT35_HUMANMRPS35physical
26344197
PTCD3_HUMANPTCD3physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
611719Combined oxidative phosphorylation deficiency 5 (COXPD5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RT22_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-211; LYS-255 AND LYS-258,AND MASS SPECTROMETRY.

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