RM19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM19_HUMAN
• UniProt AC: P49406
• Protein Name: 39S ribosomal protein L19, mitochondrial
• Gene Name: MRPL19
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAACIAAGHWAAMGLGRSFQAARTLLPPPASIACRVHAGPVRQQSTGPSEPGAFQPPPKPVIVDKHRPVEPERRFLSPEFIPRRGRTDPLKFQIERKDMLERRKVLHIPEFYVGSILRVTTADPYASGKISQFLGICIQRSGRGLGATFILRNVIEGQGVEICFELYNPRVQEIQVVKLEKRLDDSLLYLRDALPEYSTFDVNMKPVVQEPNQKVPVNELKVKMKPKPWSKRWERPNFNIKGIRFDLCLTEQQMKEAQKWNQPWLEFDMMREYDTSKIEAAIWKEIEASKRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	TLLPPPASIACRVHA HHCCCCCEEEEEEEE	19.25	24719451
45	Phosphorylation	AGPVRQQSTGPSEPG ECCCCCCCCCCCCCC	27.30	27282143
46	Phosphorylation	GPVRQQSTGPSEPGA CCCCCCCCCCCCCCC	49.09	27282143
49	Phosphorylation	RQQSTGPSEPGAFQP CCCCCCCCCCCCCCC	58.74	28348404
77	Phosphorylation	EPERRFLSPEFIPRR CHHHCCCCCCCCCCC	21.48	30266825
91	Ubiquitination	RGRTDPLKFQIERKD CCCCCCCCEEEECHH	40.38	24816145
112	Phosphorylation	VLHIPEFYVGSILRV EECCCCHHHCCEEEE	11.39	22817900
127	O-linked_Glycosylation	TTADPYASGKISQFL EECCHHHCCCHHHHH	34.47	30379171
178	Malonylation	VQEIQVVKLEKRLDD CCEEEEEEEEHHCCH	52.66	26320211
178	Acetylation	VQEIQVVKLEKRLDD CCEEEEEEEEHHCCH	52.66	23236377
186	Phosphorylation	LEKRLDDSLLYLRDA EEHHCCHHHHHHHHH	21.68	20068231
186	O-linked_Glycosylation	LEKRLDDSLLYLRDA EEHHCCHHHHHHHHH	21.68	30379171
189	Phosphorylation	RLDDSLLYLRDALPE HCCHHHHHHHHHCCC	12.65	20068231
197	Phosphorylation	LRDALPEYSTFDVNM HHHHCCCCCCCCCCC	15.86	-
205	Ubiquitination	STFDVNMKPVVQEPN CCCCCCCCCCCCCCC	29.47	29967540
214	Ubiquitination	VVQEPNQKVPVNELK CCCCCCCCCCCCCCE	55.96	29967540
221	Ubiquitination	KVPVNELKVKMKPKP CCCCCCCEEECCCCC	33.36	29967540
221	Malonylation	KVPVNELKVKMKPKP CCCCCCCEEECCCCC	33.36	26320211
221	Acetylation	KVPVNELKVKMKPKP CCCCCCCEEECCCCC	33.36	25953088
221	Succinylation	KVPVNELKVKMKPKP CCCCCCCEEECCCCC	33.36	23954790
250	Phosphorylation	IRFDLCLTEQQMKEA EEEEEECCHHHHHHH	30.65	25003641
254	Sulfoxidation	LCLTEQQMKEAQKWN EECCHHHHHHHHHCC	4.18	21406390
277	Acetylation	MREYDTSKIEAAIWK HHCCCHHHHHHHHHH	46.81	23236377
284	Ubiquitination	KIEAAIWKEIEASKR HHHHHHHHHHHHHHC	42.58	29967540
284	Malonylation	KIEAAIWKEIEASKR HHHHHHHHHHHHHHC	42.58	26320211
284	Succinylation	KIEAAIWKEIEASKR HHHHHHHHHHHHHHC	42.58	23954790
290	2-Hydroxyisobutyrylation	WKEIEASKRS----- HHHHHHHHCC-----	64.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RM24_HUMAN	MRPL24	physical	22939629
RM50_HUMAN	MRPL50	physical	22939629
RM44_HUMAN	MRPL44	physical	22939629
RM38_HUMAN	MRPL38	physical	22939629
RM40_HUMAN	MRPL40	physical	22939629
RM21_HUMAN	MRPL21	physical	22939629
RM39_HUMAN	MRPL39	physical	22939629
TSR1_HUMAN	TSR1	physical	22939629
TM177_HUMAN	TMEM177	physical	22939629
RT63_HUMAN	MRPL57	physical	22939629
ICT1_HUMAN	ICT1	physical	26344197
RM47_HUMAN	MRPL47	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.