TM177_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM177_HUMAN
• UniProt AC: Q53S58
• Protein Name: Transmembrane protein 177
• Gene Name: TMEM177
• Organism: Homo sapiens (Human).
• Sequence Length: 311
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein..
• Protein Sequence: MAGPLWRTAAFVQRHRTGLLVGSCAGLFGVPISYHLFPDPVVQWLYQYWPQGQPAPLPPQLQSLFQEVLQDIGVPSGHCYKPFTTFTFQPVSAGFPRLPAGAVVGIPASFLGDLVINTNHPVVIHGHTVDWRSPAGARLRASLTLSREAQKFALAREVVYLESSTTAVHALLAPACLAGTWALGVGAKYTLGLHAGPMNLRAAFSLVAAVAGFVAYAFSQDSLTHAVESWLDRRTASLSAAYACGGVEFYEKLLSGNLALRSLLGKDGEKLYTPSGNIVPRHLFRIKHLPYTTRRDSVLQMWRGMLNPGRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
144	Phosphorylation	ARLRASLTLSREAQK HHHHEEEEECHHHHH	21.86	24719451
275	Phosphorylation	GEKLYTPSGNIVPRH CCEEECCCCCCCCHH	36.35	26437602
297	Phosphorylation	PYTTRRDSVLQMWRG CCCCCHHHHHHHHHH	23.94	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM177_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM177_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM177_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSR1_HUMAN	TSR1	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.