dbPTM

ICT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ICT1_HUMAN
UniProt AC	Q14197
Protein Name	Peptidyl-tRNA hydrolase ICT1, mitochondrial
Gene Name	MRPL58 {ECO:0000312\|HGNC:HGNC:5359}
Organism	Homo sapiens (Human).
Sequence Length	206
Subcellular Localization	Mitochondrion .
Protein Description	Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes..
Protein Sequence	MAATRCLRWGLSRAGVWLLPPPARCPRRALHKQKDGTEFKSIYSLDKLYPESQGSDTAWRVPNGAKQADSDIPLDRLTISYCRSSGPGGQNVNKVNSKAEVRFHLATAEWIAEPVRQKIAITHKNKINRLGELILTSESSRYQFRNLADCLQKIRDMITEASQTPKEPTKEDVKLHRIRIENMNRERLRQKRIHSAVKTSRRVDMD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Ubiquitination	HKQKDGTEFKSIYSL HCCCCCCCCCEEEEH	57.52	24816145
43	Phosphorylation	GTEFKSIYSLDKLYP CCCCCEEEEHHHHCC	15.40	-
44	Phosphorylation	TEFKSIYSLDKLYPE CCCCEEEEHHHHCCC	28.55	-
47	Ubiquitination	KSIYSLDKLYPESQG CEEEEHHHHCCCCCC	56.04	21890473
47	Ubiquitination	KSIYSLDKLYPESQG CEEEEHHHHCCCCCC	56.04	21890473
49	Phosphorylation	IYSLDKLYPESQGSD EEEHHHHCCCCCCCC	15.64	28152594
66	Ubiquitination	WRVPNGAKQADSDIP EECCCCCCCCCCCCC	47.63	21890473
66	Ubiquitination	WRVPNGAKQADSDIP EECCCCCCCCCCCCC	47.63	21890473
70	Phosphorylation	NGAKQADSDIPLDRL CCCCCCCCCCCHHHE	40.22	-
76	Methylation	DSDIPLDRLTISYCR CCCCCHHHEEEEHHH	41.22	115480125
84	Phosphorylation	LTISYCRSSGPGGQN EEEEHHHCCCCCCCC	35.76	-
85	Phosphorylation	TISYCRSSGPGGQNV EEEHHHCCCCCCCCC	29.65	-
93	Ubiquitination	GPGGQNVNKVNSKAE CCCCCCCCCCCCCCE	50.54	24816145
94	Acetylation	PGGQNVNKVNSKAEV CCCCCCCCCCCCCEE	38.21	25953088
97	Phosphorylation	QNVNKVNSKAEVRFH CCCCCCCCCCEEEEE	35.91	-
98	Acetylation	NVNKVNSKAEVRFHL CCCCCCCCCEEEEEE	43.28	25953088
98	Succinylation	NVNKVNSKAEVRFHL CCCCCCCCCEEEEEE	43.28	23954790
98	Ubiquitination	NVNKVNSKAEVRFHL CCCCCCCCCEEEEEE	43.28	24816145
110	Ubiquitination	FHLATAEWIAEPVRQ EEEHHHHHHHHHHHH	7.82	24816145
153	Ubiquitination	NLADCLQKIRDMITE CHHHHHHHHHHHHHH	27.10	24816145
159	Phosphorylation	QKIRDMITEASQTPK HHHHHHHHHHHCCCC	20.89	21406692
162	Phosphorylation	RDMITEASQTPKEPT HHHHHHHHCCCCCCC	28.49	21406692
164	Phosphorylation	MITEASQTPKEPTKE HHHHHHCCCCCCCHH	33.56	21406692
169	Phosphorylation	SQTPKEPTKEDVKLH HCCCCCCCHHHHHHH	48.43	21406692
170	Ubiquitination	QTPKEPTKEDVKLHR CCCCCCCHHHHHHHH	63.73	24816145
195	Phosphorylation	LRQKRIHSAVKTSRR HHHHHHHHHHHHHCC	32.17	28509920
199	Phosphorylation	RIHSAVKTSRRVDMD HHHHHHHHHCCCCCC	22.37	28509920
200	Phosphorylation	IHSAVKTSRRVDMD- HHHHHHHHCCCCCC-	16.63	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ICT1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ICT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ICT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATD3B_HUMAN	ATAD3B	physical	20186120
ACAD9_HUMAN	ACAD9	physical	20186120
ACADV_HUMAN	ACADVL	physical	20186120
ACOT9_HUMAN	ACOT9	physical	20186120
AP2M1_HUMAN	AP2M1	physical	20186120
AFG32_HUMAN	AFG3L2	physical	20186120
AL1L2_HUMAN	ALDH1L2	physical	20186120
AASS_HUMAN	AASS	physical	20186120
AT5F1_HUMAN	ATP5F1	physical	20186120
ATP5H_HUMAN	ATP5H	physical	20186120
ATP5L_HUMAN	ATP5L	physical	20186120
ATPA_HUMAN	ATP5A1	physical	20186120
ATPB_HUMAN	ATP5B	physical	20186120
ATPG_HUMAN	ATP5C1	physical	20186120
ABCB7_HUMAN	ABCB7	physical	20186120
PGAM5_HUMAN	PGAM5	physical	20186120
CPT2_HUMAN	CPT2	physical	20186120
HDHD5_HUMAN	CECR5	physical	20186120
NDUAD_HUMAN	NDUFA13	physical	20186120
COQ8A_HUMAN	ADCK3	physical	20186120
CH60_HUMAN	HSPD1	physical	20186120
NDUF3_HUMAN	NDUFAF3	physical	20186120
GTPBA_HUMAN	GTPBP10	physical	20186120
CLPX_HUMAN	CLPX	physical	20186120
MMAB_HUMAN	MMAB	physical	20186120
MCU_HUMAN	MCU	physical	20186120
CHCH1_HUMAN	CHCHD1	physical	20186120
C1QBP_HUMAN	C1QBP	physical	20186120
COX2_HUMAN	COX2	physical	20186120
COX41_HUMAN	COX4I1	physical	20186120
DDX28_HUMAN	DDX28	physical	20186120
DHX30_HUMAN	DHX30	physical	20186120
RT29_HUMAN	DAP3	physical	20186120
PDIP2_HUMAN	POLDIP2	physical	20186120
TOP1_HUMAN	TOP1	physical	20186120
DNJA3_HUMAN	DNAJA3	physical	20186120
ECI1_HUMAN	ECI1	physical	20186120
ETFA_HUMAN	ETFA	physical	20186120
ERAL1_HUMAN	ERAL1	physical	20186120
FAKD2_HUMAN	FASTKD2	physical	20186120
FAD1_HUMAN	FLAD1	physical	20186120
DHE3_HUMAN	GLUD1	physical	20186120
GRSF1_HUMAN	GRSF1	physical	20186120
G45IP_HUMAN	GADD45GIP1	physical	20186120
GRPE1_HUMAN	GRPEL1	physical	20186120
MTG1_HUMAN	MTG1	physical	20186120
GRP75_HUMAN	HSPA9	physical	20186120
HNRDL_HUMAN	HNRNPDL	physical	20186120
HXK1_HUMAN	HK1	physical	20186120
SYHM_HUMAN	HARS2	physical	20186120
HCD2_HUMAN	HSD17B10	physical	20186120
MASU1_HUMAN	MALSU1	physical	20186120
CF203_HUMAN	C6orf203	physical	20186120
NOA1_HUMAN	NOA1	physical	20186120
MIC60_HUMAN	IMMT	physical	20186120
IF2B2_HUMAN	IGF2BP2	physical	20186120
LETM1_HUMAN	LETM1	physical	20186120
LPPRC_HUMAN	LRPPRC	physical	20186120
SYK_HUMAN	KARS	physical	20186120
MAOM_HUMAN	ME2	physical	20186120
NGRN_HUMAN	NGRN	physical	20186120
MCCB_HUMAN	MCCC2	physical	20186120
MUTA_HUMAN	MUT	physical	20186120
MET17_HUMAN	METTL17	physical	20186120
ALDH2_HUMAN	ALDH2	physical	20186120
RPOM_HUMAN	POLRMT	physical	20186120
LONM_HUMAN	LONP1	physical	20186120
FABD_HUMAN	MCAT	physical	20186120
MPPB_HUMAN	PMPCB	physical	20186120
RM01_HUMAN	MRPL1	physical	20186120
RM10_HUMAN	MRPL10	physical	20186120
RM11_HUMAN	MRPL11	physical	20186120
RM12_HUMAN	MRPL12	physical	20186120
RM13_HUMAN	MRPL13	physical	20186120
RM14_HUMAN	MRPL14	physical	20186120
RM15_HUMAN	MRPL15	physical	20186120
RM16_HUMAN	MRPL16	physical	20186120
RM17_HUMAN	MRPL17	physical	20186120
RM18_HUMAN	MRPL18	physical	20186120
RM19_HUMAN	MRPL19	physical	20186120
RM02_HUMAN	MRPL2	physical	20186120
RM22_HUMAN	MRPL22	physical	20186120
RM23_HUMAN	MRPL23	physical	20186120
RM24_HUMAN	MRPL24	physical	20186120
RM27_HUMAN	MRPL27	physical	20186120
RM28_HUMAN	MRPL28	physical	20186120
RM03_HUMAN	MRPL3	physical	20186120
RM32_HUMAN	MRPL32	physical	20186120
RM37_HUMAN	MRPL37	physical	20186120
RM39_HUMAN	MRPL39	physical	20186120
RM04_HUMAN	MRPL4	physical	20186120
RM40_HUMAN	MRPL40	physical	20186120
RM41_HUMAN	MRPL41	physical	20186120
RM43_HUMAN	MRPL43	physical	20186120
RM44_HUMAN	MRPL44	physical	20186120
RM46_HUMAN	MRPL46	physical	20186120
RM47_HUMAN	MRPL47	physical	20186120
RM48_HUMAN	MRPL48	physical	20186120
RM49_HUMAN	MRPL49	physical	20186120
RM50_HUMAN	MRPL50	physical	20186120
RM51_HUMAN	MRPL51	physical	20186120
RM54_HUMAN	MRPL54	physical	20186120
RM55_HUMAN	MRPL55	physical	20186120
RM09_HUMAN	MRPL9	physical	20186120
RT10_HUMAN	MRPS10	physical	20186120
RT11_HUMAN	MRPS11	physical	20186120
RT14_HUMAN	MRPS14	physical	20186120
RT15_HUMAN	MRPS15	physical	20186120
RT16_HUMAN	MRPS16	physical	20186120
RT17_HUMAN	MRPS17	physical	20186120
RT18A_HUMAN	MRPS18A	physical	20186120
RT18B_HUMAN	MRPS18B	physical	20186120
RT02_HUMAN	MRPS2	physical	20186120
RT21_HUMAN	MRPS21	physical	20186120
RT22_HUMAN	MRPS22	physical	20186120
RT23_HUMAN	MRPS23	physical	20186120
RT24_HUMAN	MRPS24	physical	20186120
RT25_HUMAN	MRPS25	physical	20186120
RT26_HUMAN	MRPS26	physical	20186120
RT27_HUMAN	MRPS27	physical	20186120
RT28_HUMAN	MRPS28	physical	20186120
RT30_HUMAN	MRPS30	physical	20186120
RT31_HUMAN	MRPS31	physical	20186120
RT34_HUMAN	MRPS34	physical	20186120
RT35_HUMAN	MRPS35	physical	20186120
RT05_HUMAN	MRPS5	physical	20186120
RT06_HUMAN	MRPS6	physical	20186120
RT07_HUMAN	MRPS7	physical	20186120
RT09_HUMAN	MRPS9	physical	20186120
RRFM_HUMAN	MRRF	physical	20186120
MRM1_HUMAN	MRM1	physical	20186120
MTEF1_HUMAN	MTERF1	physical	20186120
IF2M_HUMAN	MTIF2	physical	20186120
ECHA_HUMAN	HADHA	physical	20186120
MOV10_HUMAN	MOV10	physical	20186120
MTEF3_HUMAN	MTERF3	physical	20186120
MTEF4_HUMAN	MTERF4	physical	20186120
AGK_HUMAN	AGK	physical	20186120
NDUA9_HUMAN	NDUFA9	physical	20186120
NDUS1_HUMAN	NDUFS1	physical	20186120
NDUS2_HUMAN	NDUFS2	physical	20186120
NDUS3_HUMAN	NDUFS3	physical	20186120
NDUS8_HUMAN	NDUFS8	physical	20186120
NDUV1_HUMAN	NDUFV1	physical	20186120
NIPS1_HUMAN	NIPSNAP1	physical	20186120
NSUN4_HUMAN	NSUN4	physical	20186120
NDKM_HUMAN	NME4	physical	20186120
OAT_HUMAN	OAT	physical	20186120
OXA1L_HUMAN	OXA1L	physical	20186120
PTCD1_HUMAN	PTCD1	physical	20186120
PTCD3_HUMAN	PTCD3	physical	20186120
MPPA_HUMAN	PMPCA	physical	20186120
PRDX5_HUMAN	PRDX5	physical	20186120
ECH1_HUMAN	ECH1	physical	20186120
SYFM_HUMAN	FARS2	physical	20186120
PNPT1_HUMAN	PNPT1	physical	20186120
RM20_HUMAN	MRPL20	physical	20186120
PHB_HUMAN	PHB	physical	20186120
PHB2_HUMAN	PHB2	physical	20186120
SYPM_HUMAN	PARS2	physical	20186120
PCCB_HUMAN	PCCB	physical	20186120
TRUA_HUMAN	PUS1	physical	20186120
PUSL1_HUMAN	PUSL1	physical	20186120
P5CR2_HUMAN	PYCR2	physical	20186120
P5CS_HUMAN	ALDH18A1	physical	20186120
PDK3_HUMAN	PDK3	physical	20186120
MRM3_HUMAN	RNMTL1	physical	20186120
RUSD3_HUMAN	RPUSD3	physical	20186120
GLYM_HUMAN	SHMT2	physical	20186120
SYSM_HUMAN	SARS2	physical	20186120
SFXN1_HUMAN	SFXN1	physical	20186120
SSBP_HUMAN	SSBP1	physical	20186120
GHC2_HUMAN	SLC25A18	physical	20186120
CMC1_HUMAN	SLC25A12	physical	20186120
ADT1_HUMAN	SLC25A4	physical	20186120
TXTP_HUMAN	SLC25A1	physical	20186120
DIC_HUMAN	SLC25A10	physical	20186120
M2OM_HUMAN	SLC25A11	physical	20186120
MPCP_HUMAN	SLC25A3	physical	20186120
CMC2_HUMAN	SLC25A13	physical	20186120
ADT2_HUMAN	SLC25A5	physical	20186120
ADT3_HUMAN	SLC25A6	physical	20186120
ERLN2_HUMAN	ERLIN2	physical	20186120
SLIRP_HUMAN	SLIRP	physical	20186120
STML2_HUMAN	STOML2	physical	20186120
SDHA_HUMAN	SDHA	physical	20186120
SUCB1_HUMAN	SUCLA2	physical	20186120
SUV3_HUMAN	SUPV3L1	physical	20186120
PRDX4_HUMAN	PRDX4	physical	20186120
THNS1_HUMAN	THNSL1	physical	20186120
SYTM_HUMAN	TARS2	physical	20186120
TFAM_HUMAN	TFAM	physical	20186120
TRUB2_HUMAN	TRUB2	physical	20186120
EFTU_HUMAN	TUFM	physical	20186120
PEO1_HUMAN	C10orf2	physical	20186120
SYYM_HUMAN	YARS2	physical	20186120
QCR1_HUMAN	UQCRC1	physical	20186120
QCR2_HUMAN	UQCRC2	physical	20186120
ISCA1_HUMAN	ISCA1	physical	20186120
SYVM_HUMAN	VARS2	physical	20186120
VDAC1_HUMAN	VDAC1	physical	20186120
VDAC3_HUMAN	VDAC3	physical	20186120
RCC1L_HUMAN	WBSCR16	physical	20186120
YMEL1_HUMAN	YME1L1	physical	20186120
A4_HUMAN	APP	physical	21832049
RM13_HUMAN	MRPL13	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
RM51_HUMAN	MRPL51	physical	22939629
RM55_HUMAN	MRPL55	physical	22939629
RM03_HUMAN	MRPL3	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
RM04_HUMAN	MRPL4	physical	22939629
RM10_HUMAN	MRPL10	physical	22939629
RM12_HUMAN	MRPL12	physical	22939629
UCRI_HUMAN	UQCRFS1	physical	22939629
SYJ2B_HUMAN	SYNJ2BP	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RM42_HUMAN	MRPL42	physical	22939629
RM52_HUMAN	MRPL52	physical	22939629
RM39_HUMAN	MRPL39	physical	22939629
SRSF3_HUMAN	SRSF3	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RS18_HUMAN	RPS18	physical	22939629
SYNE2_HUMAN	SYNE2	physical	22939629
NDUB5_HUMAN	NDUFB5	physical	22939629
NDUB7_HUMAN	NDUFB7	physical	22939629
PPT2_HUMAN	PPT2	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
IF4H_HUMAN	EIF4H	physical	22939629
ILF2_HUMAN	ILF2	physical	22939629
NDUA2_HUMAN	NDUFA2	physical	22939629
RM03_HUMAN	MRPL3	physical	23892058
RM12_HUMAN	MRPL12	physical	23892058
RT29_HUMAN	DAP3	physical	23892058
RT18B_HUMAN	MRPS18B	physical	23892058
RM39_HUMAN	MRPL39	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ICT1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-169, AND MASSSPECTROMETRY.	17924679 [Abstract]