MMAB_HUMAN - dbPTM
MMAB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MMAB_HUMAN
UniProt AC Q96EY8
Protein Name Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
Gene Name MMAB
Organism Homo sapiens (Human).
Sequence Length 250
Subcellular Localization Mitochondrion .
Protein Description Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA..
Protein Sequence MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTLARYAAMKEGNQEKIYMKNDPSAESEGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAVCGLGSRLGLGSR
CCCCCCCCCCCCCCH		29.4022817900
49O-linked_GlycosylationDGDRPQPSSKTPRIP
CCCCCCCCCCCCCCC		38.9423301498
49PhosphorylationDGDRPQPSSKTPRIP
CCCCCCCCCCCCCCC		38.9420068231
50O-linked_GlycosylationGDRPQPSSKTPRIPK
CCCCCCCCCCCCCCE		47.4323301498
50PhosphorylationGDRPQPSSKTPRIPK
CCCCCCCCCCCCCCE		47.4320068231
51UbiquitinationDRPQPSSKTPRIPKI
CCCCCCCCCCCCCEE		67.8724816145
65AcetylationIYTKTGDKGFSSTFT
EEEECCCCCCCCCCC		64.3025953088
88PhosphorylationQVFEAVGTTDELSSA
CCHHHCCCHHHHHHH		25.1928258704
89PhosphorylationVFEAVGTTDELSSAI
CHHHCCCHHHHHHHH		22.8828258704
93PhosphorylationVGTTDELSSAIGFAL
CCCHHHHHHHHHHHH		18.7128258704
133PhosphorylationSALATPCSSAREAHL
HHHCCCCCCHHHHHH		28.3828857561
134PhosphorylationALATPCSSAREAHLK
HHCCCCCCHHHHHHH		37.7528857561
144UbiquitinationEAHLKYTTFKAGPIL
HHHHHEEEECCCCEE		21.7624816145
145UbiquitinationAHLKYTTFKAGPILE
HHHHEEEECCCCEEE		3.8324816145
161PhosphorylationEQWIDKYTSQLPPLT
HHHHHHHHHCCCCEE		18.7527251275
162PhosphorylationQWIDKYTSQLPPLTA
HHHHHHHHCCCCEEE		26.9927251275
168PhosphorylationTSQLPPLTAFILPSG
HHCCCCEEEEEECCC		25.8727251275
202SulfoxidationRVVPLVQMGETDANV
HCEEEEECCCCHHHH		4.0021406390
211AcetylationETDANVAKFLNRLSD
CCHHHHHHHHHHHHH		46.2123954790
211SuccinylationETDANVAKFLNRLSD
CCHHHHHHHHHHHHH		46.21-
211SuccinylationETDANVAKFLNRLSD
CCHHHHHHHHHHHHH		46.21-
217PhosphorylationAKFLNRLSDYLFTLA
HHHHHHHHHHHHHHH		22.4421406692
219PhosphorylationFLNRLSDYLFTLARY
HHHHHHHHHHHHHHH		10.5921406692
222PhosphorylationRLSDYLFTLARYAAM
HHHHHHHHHHHHHHH		19.5321406692
230SuccinylationLARYAAMKEGNQEKI
HHHHHHHHHCCCCCE		58.71-
230SuccinylationLARYAAMKEGNQEKI
HHHHHHHHHCCCCCE		58.7127452117
230AcetylationLARYAAMKEGNQEKI
HHHHHHHHHCCCCCE		58.7125953088
236UbiquitinationMKEGNQEKIYMKNDP
HHHCCCCCEEECCCC		29.4024816145
244PhosphorylationIYMKNDPSAESEGL-
EEECCCCCHHHCCC-		47.75-
247PhosphorylationKNDPSAESEGL----
CCCCCHHHCCC----		36.3625159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MMAB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MMAB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MMAB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MMAB_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
251110Methylmalonic aciduria type cblB (MMAB)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00115Cyanocobalamin
DB00200Hydroxocobalamin
Regulatory Network of MMAB_HUMAN

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Related Literatures of Post-Translational Modification

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