| UniProt ID | MTEF1_HUMAN | |
|---|---|---|
| UniProt AC | Q99551 | |
| Protein Name | Transcription termination factor 1, mitochondrial | |
| Gene Name | MTERF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 399 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.. | |
| Protein Sequence | MQSLSLGQTSISKGLNYLTIMAPGNLWHMRNNFLFGSRCWMTRFSAENIFKSVSFRLFGVKCHNTDSEPLKNEDLLKNLLTMGVDIDMARKRQPGVFHRMITNEQDLKMFLLSKGASKEVIASIISRYPRAITRTPENLSKRWDLWRKIVTSDLEIVNILERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNAPRTFSNSLDLNKQMVEFLQAAGLSLGHNDPADFVRKIIFKNPFILIQSTKRVKANIEFLRSTFNLNSEELLVLICGPGAEILDLSNDYARRSYANIKEKLFSLGCTEEEVQKFVLSYPDVIFLAEKKFNDKIDCLMEENISISQIIENPRVLDSSISTLKSRIKELVNAGCNLSTLNITLLSWSKKRYEAKLKKLSRFA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | QSLSLGQTSISKGLN CCCCCCCCCHHCCCC | 27690223 | ||
| 19 | Phosphorylation | SKGLNYLTIMAPGNL HCCCCEEEEECCCCC | 20860994 | ||
| 54 | Phosphorylation | ENIFKSVSFRLFGVK HHHHHHHHEEEECEE | 24719451 | ||
| 81 | Phosphorylation | DLLKNLLTMGVDIDM HHHHHHHHHCCCHHH | 30183078 | ||
| 123 | Phosphorylation | ASKEVIASIISRYPR CCHHHHHHHHHHCCC | 24719451 | ||
| 126 | Phosphorylation | EVIASIISRYPRAIT HHHHHHHHHCCCHHH | 24719451 | ||
| 128 | Phosphorylation | IASIISRYPRAITRT HHHHHHHCCCHHHCC | - | ||
| 135 | Phosphorylation | YPRAITRTPENLSKR CCCHHHCCCCCHHHH | - | ||
| 151 | Phosphorylation | DLWRKIVTSDLEIVN HHHHHHHCCCCHHHH | 28122231 | ||
| 152 | Phosphorylation | LWRKIVTSDLEIVNI HHHHHHCCCCHHHHH | 28122231 | ||
| 166 | Phosphorylation | ILERSPESFFRSNNN HHHHCHHHHHCCCCC | 24719451 | ||
| 343 | Phosphorylation | MEENISISQIIENPR HCCCCCHHHHHCCHH | 18452278 | ||
| 354 | Phosphorylation | ENPRVLDSSISTLKS CCHHHHCCHHHHHHH | 20058876 | ||
| 360 | Ubiquitination | DSSISTLKSRIKELV CCHHHHHHHHHHHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTEF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTEF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MTEF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EXC6B_HUMAN | EXOC6B | physical | 20195357 | |
| SET_HUMAN | SET | physical | 20195357 | |
| DCTN1_HUMAN | DCTN1 | physical | 20195357 | |
| SYTL2_HUMAN | SYTL2 | physical | 20195357 | |
| DJC21_HUMAN | DNAJC21 | physical | 20195357 | |
| PNPO_HUMAN | PNPO | physical | 26186194 | |
| PNPO_HUMAN | PNPO | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
