| UniProt ID | SYTL2_HUMAN | |
|---|---|---|
| UniProt AC | Q9HCH5 | |
| Protein Name | Synaptotagmin-like protein 2 | |
| Gene Name | SYTL2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 934 | |
| Subcellular Localization |
Isoform 1: Cytoplasm . Cell membrane . Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. Isoform 4: Cell membrane . In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the |
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| Protein Description | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.. | |
| Protein Sequence | MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 (in isoform 2) | Phosphorylation | - | 2.42 | - | |
| 4 (in isoform 4) | Phosphorylation | - | 2.42 | 27251275 | |
| 12 (in isoform 15) | Phosphorylation | - | 49.02 | 25849741 | |
| 38 (in isoform 11) | Phosphorylation | - | 74.00 | - | |
| 38 (in isoform 7) | Phosphorylation | - | 74.00 | - | |
| 38 (in isoform 8) | Phosphorylation | - | 74.00 | - | |
| 41 (in isoform 12) | Phosphorylation | - | 67.34 | 28348404 | |
| 50 | Phosphorylation | DQQLKNMSGQWFYEA HHHHHCCCCHHHHHH | 36.91 | - | |
| 55 | Phosphorylation | NMSGQWFYEAKAKRH CCCCHHHHHHHHHHH | 16.42 | - | |
| 57 (in isoform 11) | Phosphorylation | - | 13.01 | 27251275 | |
| 57 (in isoform 7) | Phosphorylation | - | 13.01 | 27251275 | |
| 57 (in isoform 8) | Phosphorylation | - | 13.01 | 27251275 | |
| 74 (in isoform 11) | Phosphorylation | - | 9.40 | 25849741 | |
| 74 (in isoform 7) | Phosphorylation | - | 9.40 | 25849741 | |
| 74 (in isoform 8) | Phosphorylation | - | 9.40 | 25849741 | |
| 75 | Phosphorylation | GADIIRASMRKKRPQ HHHHHHHHHHHCCCC | 14.85 | 27251275 | |
| 79 (in isoform 12) | Phosphorylation | - | 59.97 | 28348404 | |
| 88 | Phosphorylation | PQIAAEQSKDRENGA CCHHHHHCCCCCCCC | 28.20 | 28348404 | |
| 101 (in isoform 11) | Phosphorylation | - | 40.24 | 27251275 | |
| 101 (in isoform 7) | Phosphorylation | - | 40.24 | 27251275 | |
| 101 (in isoform 8) | Phosphorylation | - | 40.24 | 27251275 | |
| 105 (in isoform 11) | Phosphorylation | - | 46.26 | 26657352 | |
| 105 (in isoform 7) | Phosphorylation | - | 46.26 | 26657352 | |
| 105 (in isoform 8) | Phosphorylation | - | 46.26 | 26657352 | |
| 110 (in isoform 11) | Phosphorylation | - | 17.54 | - | |
| 110 (in isoform 7) | Phosphorylation | - | 17.54 | - | |
| 110 (in isoform 8) | Phosphorylation | - | 17.54 | - | |
| 112 (in isoform 11) | Phosphorylation | - | 49.68 | - | |
| 112 (in isoform 7) | Phosphorylation | - | 49.68 | - | |
| 112 (in isoform 8) | Phosphorylation | - | 49.68 | - | |
| 125 (in isoform 12) | Phosphorylation | - | 16.71 | 28348404 | |
| 127 (in isoform 12) | Phosphorylation | - | 29.37 | 28348404 | |
| 128 | Phosphorylation | EEDAAPASPSSSVVN CCCCCCCCCCCCCCC | 25.02 | 28348404 | |
| 130 | Phosphorylation | DAAPASPSSSVVNPA CCCCCCCCCCCCCCH | 32.52 | 28348404 | |
| 130 (in isoform 12) | Phosphorylation | - | 32.52 | 28348404 | |
| 131 | Phosphorylation | AAPASPSSSVVNPAS CCCCCCCCCCCCCHH | 30.45 | 28348404 | |
| 132 | Phosphorylation | APASPSSSVVNPASS CCCCCCCCCCCCHHH | 34.13 | 29496963 | |
| 132 (in isoform 12) | Phosphorylation | - | 34.13 | 28348404 | |
| 133 (in isoform 11) | Phosphorylation | - | 5.36 | 25849741 | |
| 133 (in isoform 12) | Phosphorylation | - | 5.36 | 28348404 | |
| 133 (in isoform 7) | Phosphorylation | - | 5.36 | 25849741 | |
| 133 (in isoform 8) | Phosphorylation | - | 5.36 | 25849741 | |
| 142 (in isoform 11) | Phosphorylation | - | 28.64 | - | |
| 142 (in isoform 7) | Phosphorylation | - | 28.64 | - | |
| 142 (in isoform 8) | Phosphorylation | - | 28.64 | - | |
| 143 (in isoform 11) | Phosphorylation | - | 2.83 | 24719451 | |
| 143 (in isoform 7) | Phosphorylation | - | 2.83 | 24719451 | |
| 143 (in isoform 8) | Phosphorylation | - | 2.83 | 24719451 | |
| 154 | Phosphorylation | NTRKPNVSPEKRKNP CCCCCCCCHHHCCCC | 33.70 | 25849741 | |
| 154 (in isoform 13) | Phosphorylation | - | 33.70 | 24706070 | |
| 164 | Phosphorylation | KRKNPFNSSKLPEGH HCCCCCCCCCCCCCC | 29.27 | - | |
| 186 | O-linked_Glycosylation | EQSKNGRTGLFQTSK CCCCCCCCCCEECCC | 39.37 | 30379171 | |
| 186 | Phosphorylation | EQSKNGRTGLFQTSK CCCCCCCCCCEECCC | 39.37 | 23312004 | |
| 186 (in isoform 12) | Phosphorylation | - | 39.37 | - | |
| 190 (in isoform 12) | Phosphorylation | - | 50.32 | 26657352 | |
| 191 | Phosphorylation | GRTGLFQTSKEDELS CCCCCEECCCHHHHC | 34.14 | 23312004 | |
| 192 | Phosphorylation | RTGLFQTSKEDELSE CCCCEECCCHHHHCC | 24.22 | 23312004 | |
| 194 (in isoform 12) | Phosphorylation | - | 57.39 | 26657352 | |
| 196 (in isoform 12) | Phosphorylation | - | 56.11 | 25849741 | |
| 197 (in isoform 11) | Phosphorylation | - | 12.15 | 28348404 | |
| 197 (in isoform 7) | Phosphorylation | - | 12.15 | 28348404 | |
| 197 (in isoform 8) | Phosphorylation | - | 12.15 | 28348404 | |
| 198 | Phosphorylation | TSKEDELSESKEKST CCCHHHHCCCHHHCC | 37.46 | 28348404 | |
| 199 (in isoform 11) | Phosphorylation | - | 77.71 | 28348404 | |
| 199 (in isoform 7) | Phosphorylation | - | 77.71 | 28348404 | |
| 199 (in isoform 8) | Phosphorylation | - | 77.71 | 28348404 | |
| 209 (in isoform 12) | Phosphorylation | - | 20.28 | 27251275 | |
| 210 (in isoform 12) | Phosphorylation | - | 24.46 | 28348404 | |
| 232 (in isoform 12) | Phosphorylation | - | 14.64 | - | |
| 241 (in isoform 11) | Phosphorylation | - | 4.37 | 25849741 | |
| 241 (in isoform 7) | Phosphorylation | - | 4.37 | 25849741 | |
| 241 (in isoform 8) | Phosphorylation | - | 4.37 | 25849741 | |
| 242 | Phosphorylation | PKARKMIYKSTDLNK HHHHHHHHHCCCCCC | 8.73 | - | |
| 243 (in isoform 11) | Phosphorylation | - | 35.63 | 27251275 | |
| 243 (in isoform 7) | Phosphorylation | - | 35.63 | 27251275 | |
| 243 (in isoform 8) | Phosphorylation | - | 35.63 | 27251275 | |
| 244 | Phosphorylation | ARKMIYKSTDLNKDD HHHHHHHCCCCCCCC | 15.35 | 25849741 | |
| 245 | Phosphorylation | RKMIYKSTDLNKDDN HHHHHHCCCCCCCCC | 40.11 | 24702127 | |
| 245 (in isoform 11) | Phosphorylation | - | 40.11 | 25849741 | |
| 245 (in isoform 7) | Phosphorylation | - | 40.11 | 25849741 | |
| 245 (in isoform 8) | Phosphorylation | - | 40.11 | 25849741 | |
| 246 (in isoform 12) | Phosphorylation | - | 56.17 | - | |
| 256 (in isoform 11) | Phosphorylation | - | 36.42 | 27251275 | |
| 256 (in isoform 12) | Phosphorylation | - | 36.42 | 25849741 | |
| 256 (in isoform 7) | Phosphorylation | - | 36.42 | 27251275 | |
| 256 (in isoform 8) | Phosphorylation | - | 36.42 | 27251275 | |
| 257 (in isoform 11) | Phosphorylation | - | 36.28 | 25849741 | |
| 257 (in isoform 7) | Phosphorylation | - | 36.28 | 25849741 | |
| 257 (in isoform 8) | Phosphorylation | - | 36.28 | 25849741 | |
| 259 (in isoform 11) | Phosphorylation | - | 41.60 | 25849741 | |
| 259 (in isoform 7) | Phosphorylation | - | 41.60 | 25849741 | |
| 259 (in isoform 8) | Phosphorylation | - | 41.60 | 25849741 | |
| 260 | Phosphorylation | QSFPRQRTDSLKARG CCCCCHHHHHHHHCC | 22.92 | 24719451 | |
| 262 | Phosphorylation | FPRQRTDSLKARGAP CCCHHHHHHHHCCCC | 31.02 | 26657352 | |
| 277 | Phosphorylation | RGILKRNSSSSSTDS CCEECCCCCCCCCCH | 35.31 | 25849741 | |
| 278 | Phosphorylation | GILKRNSSSSSTDSE CEECCCCCCCCCCHH | 37.48 | 25849741 | |
| 279 | Phosphorylation | ILKRNSSSSSTDSET EECCCCCCCCCCHHH | 28.29 | 23312004 | |
| 280 | Phosphorylation | LKRNSSSSSTDSETL ECCCCCCCCCCHHHH | 38.92 | 26330541 | |
| 281 | Phosphorylation | KRNSSSSSTDSETLR CCCCCCCCCCHHHHC | 37.88 | 25849741 | |
| 282 | Phosphorylation | RNSSSSSTDSETLRY CCCCCCCCCHHHHCC | 45.55 | 23312004 | |
| 284 | Phosphorylation | SSSSSTDSETLRYNH CCCCCCCHHHHCCCC | 32.35 | 28102081 | |
| 286 | Phosphorylation | SSSTDSETLRYNHNF CCCCCHHHHCCCCCC | 22.08 | 26330541 | |
| 286 (in isoform 12) | Phosphorylation | - | 22.08 | 26657352 | |
| 301 | Phosphorylation | EPKSKIVSPGLTIHE CCCHHEECCCCCHHH | 19.41 | 25849741 | |
| 305 | Phosphorylation | KIVSPGLTIHERISE HEECCCCCHHHHHCC | 26.63 | 28348404 | |
| 311 | Phosphorylation | LTIHERISEKEHSLE CCHHHHHCCCCCCCC | 49.16 | 29978859 | |
| 316 | Phosphorylation | RISEKEHSLEDNSSP HHCCCCCCCCCCCCC | 34.25 | 22617229 | |
| 321 | Phosphorylation | EHSLEDNSSPNSLEP CCCCCCCCCCCCCCC | 60.54 | 25849741 | |
| 321 (in isoform 11) | Phosphorylation | - | 60.54 | 27251275 | |
| 321 (in isoform 7) | Phosphorylation | - | 60.54 | 27251275 | |
| 321 (in isoform 8) | Phosphorylation | - | 60.54 | 27251275 | |
| 322 | Phosphorylation | HSLEDNSSPNSLEPL CCCCCCCCCCCCCCC | 34.06 | 21712546 | |
| 325 | Phosphorylation | EDNSSPNSLEPLKHV CCCCCCCCCCCCCCC | 37.18 | 25849741 | |
| 334 (in isoform 12) | Phosphorylation | - | 5.52 | 26657352 | |
| 335 | Phosphorylation | PLKHVRFSAVKDELP CCCCCEEECCCCCCC | 22.91 | 28555341 | |
| 338 (in isoform 12) | Phosphorylation | - | 45.24 | 28152594 | |
| 344 | Phosphorylation | VKDELPQSPGLIHGR CCCCCCCCCCEECCE | 20.99 | 29255136 | |
| 348 (in isoform 12) | Phosphorylation | - | 3.92 | 27251275 | |
| 350 (in isoform 12) | Phosphorylation | - | 22.05 | 27251275 | |
| 353 (in isoform 11) | Phosphorylation | - | 9.55 | 26657352 | |
| 353 (in isoform 7) | Phosphorylation | - | 9.55 | 26657352 | |
| 353 (in isoform 8) | Phosphorylation | - | 9.55 | 26657352 | |
| 357 | Phosphorylation | GREVGEFSVLESDRL CEEECEEEEEECHHH | 22.84 | - | |
| 357 (in isoform 12) | Phosphorylation | - | 22.84 | 27251275 | |
| 359 (in isoform 11) | Phosphorylation | - | 5.16 | 29116813 | |
| 359 (in isoform 12) | Phosphorylation | - | 5.16 | 25332170 | |
| 359 (in isoform 7) | Phosphorylation | - | 5.16 | 29116813 | |
| 359 (in isoform 8) | Phosphorylation | - | 5.16 | 29116813 | |
| 367 (in isoform 12) | Phosphorylation | - | 21.19 | 25332170 | |
| 377 (in isoform 12) | Phosphorylation | - | 7.39 | 25332170 | |
| 386 | Phosphorylation | SDPKPSQYRKPSLFH CCCCHHHCCCCCCCC | 25.58 | - | |
| 390 | Phosphorylation | PSQYRKPSLFHQSTS HHHCCCCCCCCCCCC | 46.86 | 25849741 | |
| 395 | Phosphorylation | KPSLFHQSTSSPYVS CCCCCCCCCCCCCCC | 22.99 | 29978859 | |
| 396 | Phosphorylation | PSLFHQSTSSPYVSK CCCCCCCCCCCCCCC | 27.01 | 29978859 | |
| 397 | Phosphorylation | SLFHQSTSSPYVSKS CCCCCCCCCCCCCCC | 34.26 | 26657352 | |
| 398 | Phosphorylation | LFHQSTSSPYVSKSE CCCCCCCCCCCCCCC | 21.97 | 29978859 | |
| 398 (in isoform 12) | Phosphorylation | - | 21.97 | 26552605 | |
| 399 (in isoform 12) | Phosphorylation | - | 33.06 | 26552605 | |
| 400 | Phosphorylation | HQSTSSPYVSKSETH CCCCCCCCCCCCCCC | 21.21 | 29978859 | |
| 401 (in isoform 12) | Phosphorylation | - | 7.06 | 27251275 | |
| 402 | Phosphorylation | STSSPYVSKSETHQP CCCCCCCCCCCCCCC | 25.31 | 29978859 | |
| 402 (in isoform 12) | Phosphorylation | - | 25.31 | 26552605 | |
| 404 (in isoform 11) | Phosphorylation | - | 39.97 | 28348404 | |
| 404 (in isoform 7) | Phosphorylation | - | 39.97 | 28348404 | |
| 404 (in isoform 8) | Phosphorylation | - | 39.97 | 28348404 | |
| 407 (in isoform 12) | Phosphorylation | - | 26.20 | 26552605 | |
| 410 (in isoform 12) | Phosphorylation | - | 3.61 | 26552605 | |
| 412 (in isoform 12) | Phosphorylation | - | 26.62 | 26552605 | |
| 420 (in isoform 15) | Phosphorylation | - | 3.03 | 27251275 | |
| 428 | Phosphorylation | HSHSEVLTARPQSME CCCCEEECCCCCCCC | 26.29 | 24719451 | |
| 433 | Phosphorylation | VLTARPQSMENSPTI EECCCCCCCCCCCCC | 30.65 | 27362937 | |
| 437 | Phosphorylation | RPQSMENSPTINEPK CCCCCCCCCCCCCCC | 15.32 | 25849741 | |
| 439 | Phosphorylation | QSMENSPTINEPKDK CCCCCCCCCCCCCCC | 35.93 | 24300666 | |
| 442 (in isoform 11) | Phosphorylation | - | 50.29 | 28348404 | |
| 442 (in isoform 7) | Phosphorylation | - | 50.29 | 28348404 | |
| 442 (in isoform 8) | Phosphorylation | - | 50.29 | 28348404 | |
| 445 (in isoform 12) | Phosphorylation | - | 67.78 | 27135362 | |
| 446 (in isoform 12) | Phosphorylation | - | 63.11 | 27135362 | |
| 452 (in isoform 12) | Phosphorylation | - | 49.43 | 25849741 | |
| 455 | Phosphorylation | SELTRLESVLPRSPA HHHHHHHHHCCCCCH | 33.28 | 23898821 | |
| 457 (in isoform 12) | Phosphorylation | - | 3.98 | 25849741 | |
| 460 | Phosphorylation | LESVLPRSPADELSH HHHHCCCCCHHHHHC | 23.62 | 25849741 | |
| 466 | Phosphorylation | RSPADELSHCVEPEP CCCHHHHHCCCCCCC | 16.88 | 28985074 | |
| 474 | Phosphorylation | HCVEPEPSQVPGGSS CCCCCCCCCCCCCCH | 41.99 | 23312004 | |
| 480 | Phosphorylation | PSQVPGGSSRDRQQG CCCCCCCCHHCCCCC | 28.28 | 25849741 | |
| 481 | Phosphorylation | SQVPGGSSRDRQQGS CCCCCCCHHCCCCCC | 41.28 | 23312004 | |
| 488 | Phosphorylation | SRDRQQGSEEEPSPV HHCCCCCCCCCCCHH | 37.18 | 25849741 | |
| 488 (in isoform 11) | Phosphorylation | - | 37.18 | 28348404 | |
| 488 (in isoform 7) | Phosphorylation | - | 37.18 | 28348404 | |
| 488 (in isoform 8) | Phosphorylation | - | 37.18 | 28348404 | |
| 490 (in isoform 11) | Phosphorylation | - | 76.53 | 28348404 | |
| 490 (in isoform 7) | Phosphorylation | - | 76.53 | 28348404 | |
| 490 (in isoform 8) | Phosphorylation | - | 76.53 | 28348404 | |
| 493 | Phosphorylation | QGSEEEPSPVLKTLE CCCCCCCCHHHHHHH | 30.81 | 25849741 | |
| 493 (in isoform 11) | Phosphorylation | - | 30.81 | 28348404 | |
| 493 (in isoform 7) | Phosphorylation | - | 30.81 | 28348404 | |
| 493 (in isoform 8) | Phosphorylation | - | 30.81 | 28348404 | |
| 495 (in isoform 11) | Phosphorylation | - | 11.40 | 28348404 | |
| 495 (in isoform 7) | Phosphorylation | - | 11.40 | 28348404 | |
| 495 (in isoform 8) | Phosphorylation | - | 11.40 | 28348404 | |
| 496 (in isoform 11) | Phosphorylation | - | 3.89 | 28348404 | |
| 496 (in isoform 7) | Phosphorylation | - | 3.89 | 28348404 | |
| 496 (in isoform 8) | Phosphorylation | - | 3.89 | 28348404 | |
| 509 | Phosphorylation | SAARKMPSKSLEDIS HHHHHCCCCCHHHHC | 31.23 | 25849741 | |
| 511 | Phosphorylation | ARKMPSKSLEDISSD HHHCCCCCHHHHCCC | 41.13 | 22115753 | |
| 516 | Phosphorylation | SKSLEDISSDSSNQA CCCHHHHCCCCCCCH | 40.18 | 25849741 | |
| 517 | Phosphorylation | KSLEDISSDSSNQAK CCHHHHCCCCCCCHH | 41.67 | 25849741 | |
| 519 | Phosphorylation | LEDISSDSSNQAKVD HHHHCCCCCCCHHCC | 32.89 | 25849741 | |
| 520 | Phosphorylation | EDISSDSSNQAKVDN HHHCCCCCCCHHCCC | 37.64 | 25849741 | |
| 535 | Phosphorylation | QPEELVRSAEDVSTV CHHHHHHCCHHHCCC | 28.65 | 23401153 | |
| 540 | Phosphorylation | VRSAEDVSTVPTQPD HHCCHHHCCCCCCCC | 35.69 | 29978859 | |
| 541 | Phosphorylation | RSAEDVSTVPTQPDN HCCHHHCCCCCCCCC | 30.28 | 29978859 | |
| 544 | Phosphorylation | EDVSTVPTQPDNPFS HHHCCCCCCCCCCCC | 48.69 | 28102081 | |
| 549 (in isoform 11) | Phosphorylation | - | 39.23 | - | |
| 549 (in isoform 7) | Phosphorylation | - | 39.23 | - | |
| 549 (in isoform 8) | Phosphorylation | - | 39.23 | - | |
| 553 (in isoform 11) | Phosphorylation | - | 38.95 | 26657352 | |
| 553 (in isoform 7) | Phosphorylation | - | 38.95 | 26657352 | |
| 553 (in isoform 8) | Phosphorylation | - | 38.95 | 26657352 | |
| 557 (in isoform 11) | Phosphorylation | - | 52.36 | 26657352 | |
| 557 (in isoform 7) | Phosphorylation | - | 52.36 | 26657352 | |
| 557 (in isoform 8) | Phosphorylation | - | 52.36 | 26657352 | |
| 559 (in isoform 11) | Phosphorylation | - | 5.90 | 25849741 | |
| 559 (in isoform 7) | Phosphorylation | - | 5.90 | 25849741 | |
| 559 (in isoform 8) | Phosphorylation | - | 5.90 | 25849741 | |
| 562 | Phosphorylation | KLKRMSKSVPAFLQD HHHHHHCCCCCHHCC | 26.48 | 25849741 | |
| 571 | Phosphorylation | PAFLQDESDDRETDT CCHHCCCCCCCCCCC | 53.77 | 22617229 | |
| 572 (in isoform 11) | Phosphorylation | - | 57.87 | 27251275 | |
| 572 (in isoform 7) | Phosphorylation | - | 57.87 | 27251275 | |
| 572 (in isoform 8) | Phosphorylation | - | 57.87 | 27251275 | |
| 573 (in isoform 11) | Phosphorylation | - | 60.64 | 28348404 | |
| 573 (in isoform 7) | Phosphorylation | - | 60.64 | 28348404 | |
| 573 (in isoform 8) | Phosphorylation | - | 60.64 | 28348404 | |
| 576 | Phosphorylation | DESDDRETDTASESS CCCCCCCCCCCCHHH | 39.27 | 25849741 | |
| 578 | Phosphorylation | SDDRETDTASESSYQ CCCCCCCCCCHHHHH | 39.23 | 25849741 | |
| 578 (in isoform 6) | Phosphorylation | - | 39.23 | 27251275 | |
| 580 | Phosphorylation | DRETDTASESSYQLS CCCCCCCCHHHHHHH | 39.85 | 25849741 | |
| 582 | Phosphorylation | ETDTASESSYQLSRH CCCCCCHHHHHHHHC | 31.67 | 29978859 | |
| 583 | O-linked_Glycosylation | TDTASESSYQLSRHK CCCCCHHHHHHHHCC | 16.91 | 30379171 | |
| 583 | Phosphorylation | TDTASESSYQLSRHK CCCCCHHHHHHHHCC | 16.91 | 25849741 | |
| 584 | Phosphorylation | DTASESSYQLSRHKK CCCCHHHHHHHHCCC | 23.81 | 29978859 | |
| 587 | Phosphorylation | SESSYQLSRHKKSPS CHHHHHHHHCCCCHH | 19.47 | 29978859 | |
| 592 | Phosphorylation | QLSRHKKSPSSLTNL HHHHCCCCHHHHCCC | 34.51 | 28348404 | |
| 594 | Phosphorylation | SRHKKSPSSLTNLSS HHCCCCHHHHCCCCC | 45.10 | 28348404 | |
| 595 | Phosphorylation | RHKKSPSSLTNLSSS HCCCCHHHHCCCCCC | 42.47 | 28348404 | |
| 595 (in isoform 11) | Phosphorylation | - | 42.47 | - | |
| 595 (in isoform 7) | Phosphorylation | - | 42.47 | - | |
| 595 (in isoform 8) | Phosphorylation | - | 42.47 | - | |
| 597 | Phosphorylation | KKSPSSLTNLSSSSG CCCHHHHCCCCCCCC | 35.74 | 28348404 | |
| 609 (in isoform 11) | Phosphorylation | - | 28.58 | - | |
| 609 (in isoform 7) | Phosphorylation | - | 28.58 | - | |
| 609 (in isoform 8) | Phosphorylation | - | 28.58 | - | |
| 619 (in isoform 11) | Phosphorylation | - | 10.30 | 25849741 | |
| 619 (in isoform 7) | Phosphorylation | - | 10.30 | 25849741 | |
| 619 (in isoform 8) | Phosphorylation | - | 10.30 | 25849741 | |
| 649 (in isoform 11) | Phosphorylation | - | 3.32 | 26657352 | |
| 649 (in isoform 7) | Phosphorylation | - | 3.32 | 26657352 | |
| 649 (in isoform 8) | Phosphorylation | - | 3.32 | 26657352 | |
| 665 | Phosphorylation | ADVKKQRSDPYVKAY HHHHHHCCCCCCEEE | 40.21 | 28152594 | |
| 668 | Phosphorylation | KKQRSDPYVKAYLLP HHHCCCCCCEEEECC | 21.41 | 28152594 | |
| 672 | Phosphorylation | SDPYVKAYLLPDKGK CCCCCEEEECCCCCC | 11.76 | 28152594 | |
| 690 | Ubiquitination | KKTLVVKKTLNPVYN CEEEEEEECCCHHHH | 46.78 | - | |
| 691 | Phosphorylation | KTLVVKKTLNPVYNE EEEEEEECCCHHHHH | 26.50 | 28857561 | |
| 696 | Phosphorylation | KKTLNPVYNEILRYK EECCCHHHHHHHHHH | 14.34 | - | |
| 697 (in isoform 11) | Phosphorylation | - | 30.02 | 26657352 | |
| 697 (in isoform 7) | Phosphorylation | - | 30.02 | 26657352 | |
| 697 (in isoform 8) | Phosphorylation | - | 30.02 | 26657352 | |
| 701 (in isoform 11) | Phosphorylation | - | 36.04 | 28152594 | |
| 701 (in isoform 7) | Phosphorylation | - | 36.04 | 28152594 | |
| 701 (in isoform 8) | Phosphorylation | - | 36.04 | 28152594 | |
| 711 (in isoform 11) | Phosphorylation | - | 27.73 | 27251275 | |
| 711 (in isoform 7) | Phosphorylation | - | 27.73 | 27251275 | |
| 711 (in isoform 8) | Phosphorylation | - | 27.73 | 27251275 | |
| 713 (in isoform 11) | Phosphorylation | - | 44.57 | 27251275 | |
| 713 (in isoform 7) | Phosphorylation | - | 44.57 | 27251275 | |
| 713 (in isoform 8) | Phosphorylation | - | 44.57 | 27251275 | |
| 720 (in isoform 11) | Phosphorylation | - | 18.97 | 27251275 | |
| 720 (in isoform 7) | Phosphorylation | - | 18.97 | 27251275 | |
| 720 (in isoform 8) | Phosphorylation | - | 18.97 | 27251275 | |
| 722 (in isoform 11) | Phosphorylation | - | 43.54 | 25332170 | |
| 722 (in isoform 7) | Phosphorylation | - | 43.54 | 25332170 | |
| 722 (in isoform 8) | Phosphorylation | - | 43.54 | 25332170 | |
| 730 (in isoform 11) | Phosphorylation | - | 6.00 | 25332170 | |
| 730 (in isoform 7) | Phosphorylation | - | 6.00 | 25332170 | |
| 730 (in isoform 8) | Phosphorylation | - | 6.00 | 25332170 | |
| 740 (in isoform 11) | Phosphorylation | - | 8.70 | 25332170 | |
| 740 (in isoform 7) | Phosphorylation | - | 8.70 | 25332170 | |
| 740 (in isoform 8) | Phosphorylation | - | 8.70 | 25332170 | |
| 761 (in isoform 11) | Phosphorylation | - | 19.69 | 26552605 | |
| 761 (in isoform 7) | Phosphorylation | - | 19.69 | 26552605 | |
| 761 (in isoform 8) | Phosphorylation | - | 19.69 | 26552605 | |
| 762 (in isoform 11) | Phosphorylation | - | 9.84 | 26552605 | |
| 762 (in isoform 7) | Phosphorylation | - | 9.84 | 26552605 | |
| 762 (in isoform 8) | Phosphorylation | - | 9.84 | 26552605 | |
| 764 (in isoform 11) | Phosphorylation | - | 6.97 | 27251275 | |
| 764 (in isoform 7) | Phosphorylation | - | 6.97 | 27251275 | |
| 764 (in isoform 8) | Phosphorylation | - | 6.97 | 27251275 | |
| 765 (in isoform 11) | Phosphorylation | - | 44.17 | 26552605 | |
| 765 (in isoform 7) | Phosphorylation | - | 44.17 | 26552605 | |
| 765 (in isoform 8) | Phosphorylation | - | 44.17 | 26552605 | |
| 770 (in isoform 11) | Phosphorylation | - | 51.43 | 26552605 | |
| 770 (in isoform 7) | Phosphorylation | - | 51.43 | 26552605 | |
| 770 (in isoform 8) | Phosphorylation | - | 51.43 | 26552605 | |
| 773 (in isoform 11) | Phosphorylation | - | 26.72 | 26552605 | |
| 773 (in isoform 7) | Phosphorylation | - | 26.72 | 26552605 | |
| 773 (in isoform 8) | Phosphorylation | - | 26.72 | 26552605 | |
| 775 (in isoform 11) | Phosphorylation | - | 6.26 | 26552605 | |
| 775 (in isoform 7) | Phosphorylation | - | 6.26 | 26552605 | |
| 775 (in isoform 8) | Phosphorylation | - | 6.26 | 26552605 | |
| 808 (in isoform 11) | Phosphorylation | - | 52.86 | 27135362 | |
| 808 (in isoform 7) | Phosphorylation | - | 52.86 | 27135362 | |
| 808 (in isoform 8) | Phosphorylation | - | 52.86 | 27135362 | |
| 809 (in isoform 11) | Phosphorylation | - | 21.27 | 27135362 | |
| 809 (in isoform 7) | Phosphorylation | - | 21.27 | 27135362 | |
| 809 (in isoform 8) | Phosphorylation | - | 21.27 | 27135362 | |
| 814 | Phosphorylation | LRGSHLNSFVKCTIL CCCCCCCHHEEEEEC | 37.46 | 24260401 | |
| 815 (in isoform 11) | Phosphorylation | - | 6.23 | 25849741 | |
| 815 (in isoform 7) | Phosphorylation | - | 6.23 | 25849741 | |
| 815 (in isoform 8) | Phosphorylation | - | 6.23 | 25849741 | |
| 820 (in isoform 11) | Phosphorylation | - | 8.03 | 25849741 | |
| 820 (in isoform 7) | Phosphorylation | - | 8.03 | 25849741 | |
| 820 (in isoform 8) | Phosphorylation | - | 8.03 | 25849741 | |
| 832 | Phosphorylation | SRKSRQKTRAVGKTT CCCHHHHCCCCCCCC | 18.60 | 30576142 | |
| 846 | Phosphorylation | TNPIFNHTMVYDGFR CCCCCCCCCEECCCC | 14.94 | 30576142 | |
| 849 | Phosphorylation | IFNHTMVYDGFRPED CCCCCCEECCCCHHH | 10.26 | 30576142 | |
| 890 | Phosphorylation | GFGTGKSYGTEVDWM ECCCCCCCCCCCCCC | 31.39 | - | |
| 900 (in isoform 11) | Phosphorylation | - | 35.57 | 27251275 | |
| 913 | Phosphorylation | LWEKMVNSPNTWIEA HHHHHHCCCCHHHHH | 14.23 | 22210691 | |
| 916 | Phosphorylation | KMVNSPNTWIEATLP HHHCCCCHHHHHHHH | 31.07 | 22210691 | |
| 1028 (in isoform 8) | Ubiquitination | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYTL2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYTL2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYTL2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RB27A_HUMAN | RAB27A | physical | 11773082 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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