NOA1_HUMAN - dbPTM
NOA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOA1_HUMAN
UniProt AC Q8NC60
Protein Name Nitric oxide-associated protein 1
Gene Name NOA1
Organism Homo sapiens (Human).
Sequence Length 698
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side .
Protein Description Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP..
Protein Sequence MLPARLPFRLLSLFLRGSAPTAARHGLREPLLERRCAAASSFQHSSSLGRELPYDPVDTEGFGEGGDMQERFLFPEYILDPEPQPTREKQLQELQQQQEEEERQRQQRREERRQQNLRARSREHPVVGHPDPALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQVSREQYLELVSAALRRPGPSLVLYMVDLLDLPDALLPDLPALVGPKQLIVLGNKVDLLPQDAPGYRQRLRERLWEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKKKGKINV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationERFLFPEYILDPEPQ
HHHCCCHHHCCCCCC		13.6625159151
89UbiquitinationEPQPTREKQLQELQQ
CCCCCHHHHHHHHHH		53.6821890473
167PhosphorylationPREKFLRTAEADGGL
CHHHHHHHHHCCCCH		30.8823312004
197PhosphorylationRALRLQVSREQYLEL
HHHHHCCCHHHHHHH		19.6920068231
306PhosphorylationNPNPPNWSRTVVRDV
CCCCCCCCCEEHHHH		25.3924719451
320PhosphorylationVRLISAKTGYGVEEL
HHHHCCCCCCCHHHH		35.0423663014
322PhosphorylationLISAKTGYGVEELIS
HHCCCCCCCHHHHHH		24.1923663014
329PhosphorylationYGVEELISALQRSWR
CCHHHHHHHHHHHHH		35.2423663014
367UbiquitinationESDYCTAKGSEAIDR
HCCCCCCCCCCCCCC		44.8329967540
396PhosphorylationKFPICNPTPYRMFKR
CCCCCCCCHHHHHHH		20.9728674419
409UbiquitinationKRHQRLKKDSTQAEE
HHHHHHHCCCCHHHH		62.6029967540
411PhosphorylationHQRLKKDSTQAEEDL
HHHHHCCCCHHHHHH		31.1623186163
412PhosphorylationQRLKKDSTQAEEDLS
HHHHCCCCHHHHHHH		41.7628450419
419PhosphorylationTQAEEDLSEQEQNQL
CHHHHHHHHHHHHHH		49.9430266825
430UbiquitinationQNQLNVLKKHGYVVG
HHHHHHHHHHCEEEE		38.1429967540
461PhosphorylationPFEFDADSLAFDMEN
CCEECCCCEEEECCC		24.2623879269
478PhosphorylationVMGTHKSTKQVELTA
CCCCCCCCCEEEEEH		30.2423879269
479UbiquitinationMGTHKSTKQVELTAQ
CCCCCCCCEEEEEHH		60.48-
484PhosphorylationSTKQVELTAQDVKDA
CCCEEEEEHHHHHHC		14.5723879269
489UbiquitinationELTAQDVKDAHWFYD
EEEHHHHHHCCEECC		58.4429967540
502UbiquitinationYDTPGITKENCILNL
CCCCCCCHHCHHHHC		45.0429967540
673TrimethylationIKGQRIKKSVAYKTK
ECCCEEEECHHCCCC		48.03-
673MethylationIKGQRIKKSVAYKTK
ECCCEEEECHHCCCC		48.03-
674PhosphorylationKGQRIKKSVAYKTKK
CCCEEEECHHCCCCC		13.6426074081
677PhosphorylationRIKKSVAYKTKKPPS
EEEECHHCCCCCCCH		19.6226074081
679PhosphorylationKKSVAYKTKKPPSLM
EECHHCCCCCCCHHH		31.4626074081
684PhosphorylationYKTKKPPSLMYNVRK
CCCCCCCHHHHCCCC		34.0026074081
687PhosphorylationKKPPSLMYNVRKKKG
CCCCHHHHCCCCCCC		18.7926074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NOA1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOA1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-77, AND MASSSPECTROMETRY.

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