| UniProt ID | ECI1_HUMAN | |
|---|---|---|
| UniProt AC | P42126 | |
| Protein Name | Enoyl-CoA delta isomerase 1, mitochondrial | |
| Gene Name | ECI1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 302 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.. | |
| Protein Sequence | MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MALVASVRVPARV --CCCEEECCCCHHH | 11.72 | 24719451 | |
| 61 (in isoform 1) | Ubiquitination | - | 46.73 | 21890473 | |
| 61 | Succinylation | GAGVAVMKFKNPPVN CCCEEEEEECCCCCC | 46.73 | 21906983 | |
| 61 | Succinylation | GAGVAVMKFKNPPVN CCCEEEEEECCCCCC | 46.73 | - | |
| 61 | Ubiquitination | GAGVAVMKFKNPPVN CCCEEEEEECCCCCC | 46.73 | - | |
| 61 (in isoform 2) | Ubiquitination | - | 46.73 | 21890473 | |
| 61 | Acetylation | GAGVAVMKFKNPPVN CCCEEEEEECCCCCC | 46.73 | 27452117 | |
| 61 | 2-Hydroxyisobutyrylation | GAGVAVMKFKNPPVN CCCEEEEEECCCCCC | 46.73 | - | |
| 84 | Succinylation | ELVISLEKLENDKSF HHHHHHHHHHCCCCC | 67.41 | - | |
| 84 | Succinylation | ELVISLEKLENDKSF HHHHHHHHHHCCCCC | 67.41 | - | |
| 89 | 2-Hydroxyisobutyrylation | LEKLENDKSFRGVIL HHHHHCCCCCCEEEE | 64.18 | - | |
| 89 | Acetylation | LEKLENDKSFRGVIL HHHHHCCCCCCEEEE | 64.18 | 19608861 | |
| 89 | Succinylation | LEKLENDKSFRGVIL HHHHHCCCCCCEEEE | 64.18 | 27452117 | |
| 171 | Methylation | RILADNPRYCIGLNE EEECCCCCEEECCCC | 45.25 | - | |
| 262 | Phosphorylation | KAMMRKATASRLVTQ HHHHHHHHHHHHHCH | 28.35 | 28842319 | |
| 266 | Acetylation | RKATASRLVTQRDAD HHHHHHHHHCHHHHH | 4.53 | 19608861 | |
| 266 (in isoform 2) | Ubiquitination | - | 4.53 | 21890473 | |
| 266 | Ubiquitination | RKATASRLVTQRDAD HHHHHHHHHCHHHHH | 4.53 | 19608861 | |
| 271 (in isoform 2) | Ubiquitination | - | 36.98 | 21890473 | |
| 279 | Phosphorylation | ADVQNFVSFISKDSI HHHHHHHHHHCHHHH | 16.84 | 23663014 | |
| 282 | Phosphorylation | QNFVSFISKDSIQKS HHHHHHHCHHHHHHH | 28.53 | 28857561 | |
| 283 | Succinylation | NFVSFISKDSIQKSL HHHHHHCHHHHHHHH | 51.16 | 27452117 | |
| 283 | Succinylation | NFVSFISKDSIQKSL HHHHHHCHHHHHHHH | 51.16 | - | |
| 283 | Ubiquitination | NFVSFISKDSIQKSL HHHHHHCHHHHHHHH | 51.16 | 21890473 | |
| 283 (in isoform 1) | Ubiquitination | - | 51.16 | 21890473 | |
| 283 | Acetylation | NFVSFISKDSIQKSL HHHHHHCHHHHHHHH | 51.16 | 23954790 | |
| 285 | Phosphorylation | VSFISKDSIQKSLQM HHHHCHHHHHHHHHH | 30.56 | 21406692 | |
| 288 | Succinylation | ISKDSIQKSLQMYLE HCHHHHHHHHHHHHH | 52.00 | - | |
| 288 | Succinylation | ISKDSIQKSLQMYLE HCHHHHHHHHHHHHH | 52.00 | 21890473 | |
| 288 | Ubiquitination | ISKDSIQKSLQMYLE HCHHHHHHHHHHHHH | 52.00 | 21890473 | |
| 288 (in isoform 1) | Ubiquitination | - | 52.00 | 21890473 | |
| 288 | Acetylation | ISKDSIQKSLQMYLE HCHHHHHHHHHHHHH | 52.00 | 2401759 | |
| 289 | Phosphorylation | SKDSIQKSLQMYLER CHHHHHHHHHHHHHH | 13.88 | 21406692 | |
| 293 | Phosphorylation | IQKSLQMYLERLKEE HHHHHHHHHHHHHHH | 7.76 | 21406692 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ECI1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ECI1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ECI1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| SIN1_HUMAN | MAPKAP1 | physical | 21988832 | |
| POTE1_HUMAN | POT1 | physical | 21988832 | |
| HIBCH_HUMAN | HIBCH | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-89 AND LYS-283, AND MASSSPECTROMETRY. | |
