NDUAD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUAD_HUMAN
• UniProt AC: Q9P0J0
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
• Gene Name: NDUFA13
• Organism: Homo sapiens (Human).
• Sequence Length: 144
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side. Nucleus . Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment.
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. [PubMed: 27626371 Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone]
• Protein Sequence: MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASKVKQD ------CCCCCCCCC	22.05	-
5	Ubiquitination	---MAASKVKQDMPP ---CCCCCCCCCCCC	49.04	22817900
7	Ubiquitination	-MAASKVKQDMPPPG -CCCCCCCCCCCCCC	44.30	21906983
16	Phosphorylation	DMPPPGGYGPIDYKR CCCCCCCCCCCCCCC	26.16	29496907
21	Phosphorylation	GGYGPIDYKRNLPRR CCCCCCCCCCCCCCC	16.74	29496907
22	Ubiquitination	GYGPIDYKRNLPRRG CCCCCCCCCCCCCCC	30.94	21890473
22	Ubiquitination	GYGPIDYKRNLPRRG CCCCCCCCCCCCCCC	30.94	27667366
22	Acetylation	GYGPIDYKRNLPRRG CCCCCCCCCCCCCCC	30.94	26051181
31	Phosphorylation	NLPRRGLSGYSMLAI CCCCCCCCHHHHHHH	38.21	25867546
33	Phosphorylation	PRRGLSGYSMLAIGI CCCCCCHHHHHHHHH	6.37	25867546
34	Phosphorylation	RRGLSGYSMLAIGIG CCCCCHHHHHHHHHC	15.73	25867546
42	Phosphorylation	MLAIGIGTLIYGHWS HHHHHHCHHHHCHHH	14.20	25867546
45	Phosphorylation	IGIGTLIYGHWSIMK HHHCHHHHCHHHHHH	13.17	25867546
49	Phosphorylation	TLIYGHWSIMKWNRE HHHHCHHHHHHHHHH	13.71	25867546
52	Ubiquitination	YGHWSIMKWNRERRR HCHHHHHHHHHHHHC	39.38	23503661
79	Phosphorylation	LPLLQAETDRRTLQM HHHHHHHHHHHHHHH	37.51	21406692
81	Methylation	LLQAETDRRTLQMLR HHHHHHHHHHHHHHH	40.69	-
90	Ubiquitination	TLQMLRENLEEEAII HHHHHHHCHHHHCEE	46.44	21890473
99	Ubiquitination	EEEAIIMKDVPDWKV HHHCEEEECCCCCCC	45.20	21963094
99	Ubiquitination	EEEAIIMKDVPDWKV HHHCEEEECCCCCCC	45.20	21890473
105	Ubiquitination	MKDVPDWKVGESVFH EECCCCCCCCCCCCC	47.98	21890473
105	Ubiquitination	MKDVPDWKVGESVFH EECCCCCCCCCCCCC	47.98	21906983
114	Phosphorylation	GESVFHTTRWVPPLI CCCCCCCCCCCCCHH	17.60	26437602
125	Phosphorylation	PPLIGELYGLRTTEE CCHHHHHHCCCCHHH	15.15	29496907
182	Ubiquitination	--------------------------------------------- ---------------------------------------------		21890473
188	Ubiquitination	--------------------------------------------------- ---------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUAD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUAD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUAD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT3_HUMAN	STAT3	physical	12867595
UBE3A_HUMAN	UBE3A	physical	21765936
NDUB6_HUMAN	NDUFB6	physical	22939629
CIA30_HUMAN	NDUFAF1	physical	24344204
TIDC1_HUMAN	TIMMDC1	physical	24344204
ECSIT_HUMAN	ECSIT	physical	24344204
ACAD9_HUMAN	ACAD9	physical	24344204
T126B_HUMAN	TMEM126B	physical	24344204
YMEL1_HUMAN	YME1L1	physical	24344204
ADT3_HUMAN	SLC25A6	physical	24344204
TRXR2_HUMAN	TXNRD2	physical	24344204
NDUF3_HUMAN	NDUFAF3	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NDUS7_HUMAN	NDUFS7	physical	24344204
TIM23_HUMAN	TIMM23	physical	24344204
AFG32_HUMAN	AFG3L2	physical	24344204
UCRI_HUMAN	UQCRFS1	physical	24344204
ATP5J_HUMAN	ATP5J	physical	24344204
S22AC_HUMAN	SLC22A12	physical	24344204
S22AK_HUMAN	SLC22A20	physical	24344204
NDUA5_HUMAN	NDUFA5	physical	24344204
NDUS3_HUMAN	NDUFS3	physical	24344204
NDUV1_HUMAN	NDUFV1	physical	24344204
NDUC2_HUMAN	NDUFC2	physical	24344204
NDUAC_HUMAN	NDUFA12	physical	24344204
NDUF4_HUMAN	NDUFAF4	physical	24344204
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUA9_HUMAN	NDUFA9	physical	24344204
NDUB3_HUMAN	NDUFB3	physical	24344204
NDUV3_HUMAN	NDUFV3	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
CPT2_HUMAN	CPT2	physical	28514442
NDUA3_HUMAN	NDUFA3	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
NDUA7_HUMAN	NDUFA7	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
T126B_HUMAN	TMEM126B	physical	28514442
NDUF4_HUMAN	NDUFAF4	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442
UQCC1_HUMAN	UQCC1	physical	28514442
VATD_HUMAN	ATP6V1D	physical	28514442
ACADV_HUMAN	ACADVL	physical	28514442
NDUS7_HUMAN	NDUFS7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607464: Hurthle cell thyroid carcinoma (HCTC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.