S22AC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22AC_HUMAN
• UniProt AC: Q96S37
• Protein Name: Solute carrier family 22 member 12
• Gene Name: SLC22A12
• Organism: Homo sapiens (Human).
• Sequence Length: 553
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Detected in the luminal membrane of the epithelium of renal proximal tubules.
• Protein Description: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions..
• Protein Sequence: MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	N-linked_Glycosylation	CWAPLLDNSTAQASI CCHHCCCCCCHHHHH	41.03	UniProtKB CARBOHYD
102	N-linked_Glycosylation	QWQLLDPNATATSWS CCEECCCCCCCCCCC	49.98	UniProtKB CARBOHYD
314	Phosphorylation	GKGAVQDTLTPEVLL CCCCCCCCCCHHHHH	18.55	22210691
316	Phosphorylation	GAVQDTLTPEVLLSA CCCCCCCCHHHHHHH	21.35	22210691
322	Phosphorylation	LTPEVLLSAMREELS CCHHHHHHHHHHHHH	18.83	22210691
542	Phosphorylation	VKKATHGTLGNSVLK HHHHCCCCCCCHHHH	24.72	28857561
546	Phosphorylation	THGTLGNSVLKSTQF CCCCCCCHHHHHCCC	27.33	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S22AC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22AC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22AC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAP2_HUMAN	SMAP2	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.