YMEL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YMEL1_HUMAN
• UniProt AC: Q96TA2
• Protein Name: ATP-dependent zinc metalloprotease YME1L1
• Gene Name: YME1L1
• Organism: Homo sapiens (Human).
• Sequence Length: 773
• Subcellular Localization: Mitochondrion inner membrane . Mitochondrion .
• Protein Description: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. [PubMed: 26923599]
• Protein Sequence: MFSLSSTVQPQVTVPLSHLINAFHTPKNTSVSLSGVSVSQNQHRDVVPEHEAPSSECMFSDFLTKLNIVSIGKGKIFEGYRSMFMEPAKRMKKSLDTTDNWHIRPEPFSLSIPPSLNLRDLGLSELKIGQIDQLVENLLPGFCKGKNISSHWHTSHVSAQSFFENKYGNLDIFSTLRSSCLYRHHSRALQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
144	Ubiquitination	NLLPGFCKGKNISSH HHCCCCCCCCCCCCC	71.33	-
146	Ubiquitination	LPGFCKGKNISSHWH CCCCCCCCCCCCCCC	36.28	-
147	Ubiquitination	PGFCKGKNISSHWHT CCCCCCCCCCCCCCC	48.30	23000965
147	Acetylation	PGFCKGKNISSHWHT CCCCCCCCCCCCCCC	48.30	19608861
163	Ubiquitination	HVSAQSFFENKYGNL CCCHHHHHHCCCCCC	14.15	21890473
166	Ubiquitination	AQSFFENKYGNLDIF HHHHHHCCCCCCCHH	47.54	22817900
168	Ubiquitination	SFFENKYGNLDIFST HHHHCCCCCCCHHHH	29.81	27667366
179	Ubiquitination	IFSTLRSSCLYRHHS HHHHHHHHHHHHHHH	11.16	21890473
180	Ubiquitination	FSTLRSSCLYRHHSR HHHHHHHHHHHHHHH	4.00	23000965
180 (in isoform 2)	Ubiquitination	-	4.00	21890473
180	Ubiquitination	FSTLRSSCLYRHHSR HHHHHHHHHHHHHHH	4.00	21890473
180	Ubiquitination	FSTLRSSCLYRHHSR HHHHHHHHHHHHHHH	4.00	21890473
180	Acetylation	FSTLRSSCLYRHHSR HHHHHHHHHHHHHHH	4.00	19608861
188	Ubiquitination	LYRHHSRALQSICSD HHHHHHHHHHHHHHH	16.99	32015554
195	Ubiquitination	ALQSICSDLQYWPVF HHHHHHHHHCCHHHH	33.12	27667366
196	Ubiquitination	LQSICSDLQYWPVFI HHHHHHHHCCHHHHH	2.12	21890473
196	Ubiquitination	LQSICSDLQYWPVFI HHHHHHHHCCHHHHH	2.12	21890473
196	Ubiquitination	LQSICSDLQYWPVFI HHHHHHHHCCHHHHH	2.12	21890473
196 (in isoform 2)	Ubiquitination	-	2.12	21890473
199	Ubiquitination	ICSDLQYWPVFIQSR HHHHHCCHHHHHHCC	3.04	22817900
201	Ubiquitination	SDLQYWPVFIQSRGF HHHCCHHHHHHCCCH	4.01	27667366
201 (in isoform 2)	Ubiquitination	-	4.01	21890473
201	Ubiquitination	SDLQYWPVFIQSRGF HHHCCHHHHHHCCCH	4.01	21890473
201	Ubiquitination	SDLQYWPVFIQSRGF HHHCCHHHHHHCCCH	4.01	21890473
204	Ubiquitination	QYWPVFIQSRGFKTL CCHHHHHHCCCHHHH	18.66	23000965
212	Ubiquitination	SRGFKTLKSRTRRLQ CCCHHHHHHHHHHHH	43.02	21890473
212	Ubiquitination	SRGFKTLKSRTRRLQ CCCHHHHHHHHHHHH	43.02	21890473
212	Ubiquitination	SRGFKTLKSRTRRLQ CCCHHHHHHHHHHHH	43.02	21890473
212 (in isoform 2)	Ubiquitination	-	43.02	21890473
220	Phosphorylation	SRTRRLQSTSERLAE HHHHHHHHHHHHHHH	38.19	17001009
220	Ubiquitination	SRTRRLQSTSERLAE HHHHHHHHHHHHHHH	38.19	21890473
221	Phosphorylation	RTRRLQSTSERLAET HHHHHHHHHHHHHHH	22.96	-
221	Ubiquitination	RTRRLQSTSERLAET HHHHHHHHHHHHHHH	22.96	32015554
221 (in isoform 2)	Ubiquitination	-	22.96	21890473
223	Ubiquitination	RRLQSTSERLAETQN HHHHHHHHHHHHHHC	52.37	22817900
225	Ubiquitination	LQSTSERLAETQNIA HHHHHHHHHHHHCCC	4.42	21890473
228	Ubiquitination	TSERLAETQNIAPSF HHHHHHHHHCCCHHH	22.70	27667366
236	Ubiquitination	QNIAPSFVKGFLLRD HCCCHHHHHHHHHCC	7.51	21890473
237	Acetylation	NIAPSFVKGFLLRDR CCCHHHHHHHHHCCC	41.77	19608861
237	Ubiquitination	NIAPSFVKGFLLRDR CCCHHHHHHHHHCCC	41.77	23000965
237 (in isoform 1)	Ubiquitination	-	41.77	21890473
244	Ubiquitination	KGFLLRDRGSDVESL HHHHHCCCCCCHHHH	39.83	22817900
245	Ubiquitination	GFLLRDRGSDVESLD HHHHCCCCCCHHHHH	32.27	22817900
246	Phosphorylation	FLLRDRGSDVESLDK HHHCCCCCCHHHHHH	39.10	21406692
250	Phosphorylation	DRGSDVESLDKLMKT CCCCCHHHHHHHHHC	41.54	21406692
252	Ubiquitination	GSDVESLDKLMKTKN CCCHHHHHHHHHCCC	51.85	27667366
253	Ubiquitination	SDVESLDKLMKTKNI CCHHHHHHHHHCCCC	56.63	22817900
253 (in isoform 1)	Ubiquitination	-	56.63	21890473
256	Ubiquitination	ESLDKLMKTKNIPEA HHHHHHHHCCCCCHH	67.78	22817900
258	Ubiquitination	LDKLMKTKNIPEAHQ HHHHHHCCCCCHHHH	47.57	27667366
258 (in isoform 1)	Ubiquitination	-	47.57	21890473
269	Ubiquitination	EAHQDAFKTGFAEGF HHHHHHHHHCCHHHH	49.84	22817900
269	Acetylation	EAHQDAFKTGFAEGF HHHHHHHHHCCHHHH	49.84	25953088
269 (in isoform 1)	Ubiquitination	-	49.84	21890473
270	Phosphorylation	AHQDAFKTGFAEGFL HHHHHHHHCCHHHHH	30.95	20068231
273	Ubiquitination	DAFKTGFAEGFLKAQ HHHHHCCHHHHHHHH	19.83	21890473
277	Ubiquitination	TGFAEGFLKAQALTQ HCCHHHHHHHHHHHH	7.08	22817900
277 (in isoform 2)	Ubiquitination	-	7.08	21890473
278	Ubiquitination	GFAEGFLKAQALTQK CCHHHHHHHHHHHHH	35.87	21906983
278	Acetylation	GFAEGFLKAQALTQK CCHHHHHHHHHHHHH	35.87	26051181
278 (in isoform 1)	Ubiquitination	-	35.87	21890473
280	Ubiquitination	AEGFLKAQALTQKTN HHHHHHHHHHHHHCC	35.00	29967540
283	Ubiquitination	FLKAQALTQKTNDSL HHHHHHHHHHCCHHH	30.91	27667366
285	Ubiquitination	KAQALTQKTNDSLRR HHHHHHHHCCHHHHH	44.02	27667366
291	Ubiquitination	QKTNDSLRRTRLILF HHCCHHHHHHHHHHH	41.71	29967540
295	Ubiquitination	DSLRRTRLILFVLLL HHHHHHHHHHHHHHH	3.84	23000965
301	Ubiquitination	RLILFVLLLFGIYGL HHHHHHHHHHHHHHH	2.90	22817900
302	Ubiquitination	LILFVLLLFGIYGLL HHHHHHHHHHHHHHH	3.02	22817900
306	Phosphorylation	VLLLFGIYGLLKNPF HHHHHHHHHHHHCCE	11.33	-
306	Ubiquitination	VLLLFGIYGLLKNPF HHHHHHHHHHHHCCE	11.33	21890473
306	Ubiquitination	VLLLFGIYGLLKNPF HHHHHHHHHHHHCCE	11.33	21890473
306	Ubiquitination	VLLLFGIYGLLKNPF HHHHHHHHHHHHCCE	11.33	21890473
306 (in isoform 2)	Ubiquitination	-	11.33	21890473
313	Ubiquitination	YGLLKNPFLSVRFRT HHHHHCCEEECEEEE	12.72	29967540
315	Phosphorylation	LLKNPFLSVRFRTTT HHHCCEEECEEEECC	16.18	-
316	Ubiquitination	LKNPFLSVRFRTTTG HHCCEEECEEEECCC	7.94	27667366
326	Ubiquitination	RTTTGLDSAVDPVQM EECCCCCCCCCCEEC	34.92	22817900
328	Ubiquitination	TTGLDSAVDPVQMKN CCCCCCCCCCEECCC	11.21	23000965
328	Ubiquitination	TTGLDSAVDPVQMKN CCCCCCCCCCEECCC	11.21	21890473
328	Ubiquitination	TTGLDSAVDPVQMKN CCCCCCCCCCEECCC	11.21	21890473
328 (in isoform 2)	Ubiquitination	-	11.21	21890473
330	Ubiquitination	GLDSAVDPVQMKNVT CCCCCCCCEECCCCC	16.19	21890473
333	Sulfoxidation	SAVDPVQMKNVTFEH CCCCCEECCCCCHHH	3.29	21406390
334	Ubiquitination	AVDPVQMKNVTFEHV CCCCEECCCCCHHHH	31.04	22817900
334 (in isoform 1)	Ubiquitination	-	31.04	21890473
340	Ubiquitination	MKNVTFEHVKGVEEA CCCCCHHHHCCHHHH	23.54	27667366
342	Ubiquitination	NVTFEHVKGVEEAKQ CCCHHHHCCHHHHHH	60.18	29967540
348	Ubiquitination	VKGVEEAKQELQEVV HCCHHHHHHHHHHHH	47.81	29967540
352	Ubiquitination	EEAKQELQEVVEFLK HHHHHHHHHHHHHHH	40.46	23000965
356	Ubiquitination	QELQEVVEFLKNPQK HHHHHHHHHHHCCCC	50.90	21963094
359	Ubiquitination	QEVVEFLKNPQKFTI HHHHHHHHCCCCEEE	72.42	22817900
363	Ubiquitination	EFLKNPQKFTILGGK HHHHCCCCEEEECCC	45.81	22817900
363 (in isoform 1)	Ubiquitination	-	45.81	21890473
370	Ubiquitination	KFTILGGKLPKGILL CEEEECCCCCCEEEE	60.87	29967540
373	Ubiquitination	ILGGKLPKGILLVGP EECCCCCCEEEEECC	69.85	27667366
385	Ubiquitination	VGPPGTGKTLLARAV ECCCCCCHHHHHHHH	35.52	23000965
385 (in isoform 1)	Ubiquitination	-	35.52	21890473
386	Phosphorylation	GPPGTGKTLLARAVA CCCCCCHHHHHHHHH	28.48	-
389	Ubiquitination	GTGKTLLARAVAGEA CCCHHHHHHHHHCCC	10.66	21963094
413	Ubiquitination	SEFDEMFVGVGASRI CCHHHCCHHHCHHHH	6.15	21963094
420	Ubiquitination	VGVGASRIRNLFREA HHHCHHHHHHHHHHH	2.95	24816145
432	Ubiquitination	REAKANAPCVIFIDE HHHHCCCCEEEEEEE	16.83	22817900
434	Ubiquitination	AKANAPCVIFIDELD HHCCCCEEEEEEECH	3.79	21890473
446	Ubiquitination	ELDSVGGKRIESPMH ECHHCCCEECCCCCC	44.25	21963094
450	Phosphorylation	VGGKRIESPMHPYSR CCCEECCCCCCCCCH	25.75	28555341
453	Ubiquitination	KRIESPMHPYSRQTI EECCCCCCCCCHHHH	22.87	24816145
465	Ubiquitination	QTINQLLAEMDGFKP HHHHHHHHHCCCCCC	20.75	22817900
466	Ubiquitination	TINQLLAEMDGFKPN HHHHHHHHCCCCCCC	37.46	21963094
467	Ubiquitination	INQLLAEMDGFKPNE HHHHHHHCCCCCCCC	5.20	21890473
467	Ubiquitination	INQLLAEMDGFKPNE HHHHHHHCCCCCCCC	5.20	21890473
467	Ubiquitination	INQLLAEMDGFKPNE HHHHHHHCCCCCCCC	5.20	21890473
467 (in isoform 2)	Ubiquitination	-	5.20	21890473
472	Ubiquitination	AEMDGFKPNEGVIII HHCCCCCCCCCEEEE	41.67	23503661
477	Ubiquitination	FKPNEGVIIIGATNF CCCCCCEEEEECCCC	2.53	24816145
478	Ubiquitination	KPNEGVIIIGATNFP CCCCCEEEEECCCCH	1.90	21890473
489	Ubiquitination	TNFPEALDNALIRPG CCCHHHHHCCCCCCC	45.46	22817900
491	Ubiquitination	FPEALDNALIRPGRF CHHHHHCCCCCCCCC	12.20	21890473
499	Ubiquitination	LIRPGRFDMQVTVPR CCCCCCCEEEEEECC	25.83	21963094
499 (in isoform 2)	Ubiquitination	-	25.83	21890473
503	Phosphorylation	GRFDMQVTVPRPDVK CCCEEEEEECCCCCC	14.11	24719451
505	Ubiquitination	FDMQVTVPRPDVKGR CEEEEEECCCCCCCH	32.49	23503661
510	Ubiquitination	TVPRPDVKGRTEILK EECCCCCCCHHHHHH	50.48	24816145
511	Ubiquitination	VPRPDVKGRTEILKW ECCCCCCCHHHHHHH	41.41	21890473
511	Ubiquitination	VPRPDVKGRTEILKW ECCCCCCCHHHHHHH	41.41	21890473
511	Ubiquitination	VPRPDVKGRTEILKW ECCCCCCCHHHHHHH	41.41	21890473
511 (in isoform 2)	Ubiquitination	-	41.41	21890473
522	Ubiquitination	ILKWYLNKIKFDQSV HHHHHHHHCCCCCCC	44.68	22817900
523	Ubiquitination	LKWYLNKIKFDQSVD HHHHHHHCCCCCCCC	5.38	21963094
524	Ubiquitination	KWYLNKIKFDQSVDP HHHHHHCCCCCCCCH	44.49	22817900
524 (in isoform 1)	Ubiquitination	-	44.49	21890473
529	Ubiquitination	KIKFDQSVDPEIIAR HCCCCCCCCHHHHHC	13.63	23503661
535	Ubiquitination	SVDPEIIARGTVGFS CCCHHHHHCCCCCCC	14.98	21890473
556	Ubiquitination	LVNQAALKAAVDGKE HHHHHHHHHHHCCCC	29.58	21906983
556 (in isoform 1)	Ubiquitination	-	29.58	21890473
562	Ubiquitination	LKAAVDGKEMVTMKE HHHHHCCCCCEEHEE	37.87	23503661
568	Ubiquitination	GKEMVTMKELEFSKD CCCCEEHEEEEECCC	50.19	21890473
568 (in isoform 1)	Ubiquitination	-	50.19	21890473
594	Phosphorylation	EIDNKNKTITAYHES EEECCCCEEEEEECC	32.71	25072903
596	Phosphorylation	DNKNKTITAYHESGH ECCCCEEEEEECCCC	26.79	25072903
598	Phosphorylation	KNKTITAYHESGHAI CCCEEEEEECCCCEE	9.47	25072903
601	Phosphorylation	TITAYHESGHAIIAY EEEEEECCCCEEEEE	23.67	25072903
608	Phosphorylation	SGHAIIAYYTKDAMP CCCEEEEEEECCCCC	10.97	25072903
609	Phosphorylation	GHAIIAYYTKDAMPI CCEEEEEEECCCCCC	9.78	25072903
610	Phosphorylation	HAIIAYYTKDAMPIN CEEEEEEECCCCCCC	15.12	25072903
618	Ubiquitination	KDAMPINKATIMPRG CCCCCCCCCEECCCC	47.85	22817900
643	Phosphorylation	ENDRWNETRAQLLAQ CCCCCCHHHHHHHHH	28.26	22210691
647	Ubiquitination	WNETRAQLLAQMDVS CCHHHHHHHHHCCCC	4.11	29967540
651	Ubiquitination	RAQLLAQMDVSMGGR HHHHHHHCCCCCCHH	4.58	22817900
651 (in isoform 2)	Ubiquitination	-	4.58	21890473
654	Ubiquitination	LLAQMDVSMGGRVAE HHHHCCCCCCHHHHH	13.88	29967540
654	Phosphorylation	LLAQMDVSMGGRVAE HHHHCCCCCCHHHHH	13.88	22210691
671	Phosphorylation	IFGTDHITTGASSDF HCCCCCCCCCCCCCC	18.76	22210691
675	Ubiquitination	DHITTGASSDFDNAT CCCCCCCCCCCCHHH	31.61	22817900
675	Phosphorylation	DHITTGASSDFDNAT CCCCCCCCCCCCHHH	31.61	22210691
676	Phosphorylation	HITTGASSDFDNATK CCCCCCCCCCCHHHH	41.59	22210691
678	Ubiquitination	TTGASSDFDNATKIA CCCCCCCCCHHHHHH	9.36	29967540
680	Ubiquitination	GASSDFDNATKIAKR CCCCCCCHHHHHHHH	49.88	29967540
683	Acetylation	SDFDNATKIAKRMVT CCCCHHHHHHHHHHH	37.95	26051181
687	Ubiquitination	NATKIAKRMVTKFGM HHHHHHHHHHHHCCC	18.78	29967540
691	Ubiquitination	IAKRMVTKFGMSEKL HHHHHHHHCCCCCCC	28.63	-
702	Phosphorylation	SEKLGVMTYSDTGKL CCCCCCEECCCCCCC	19.91	23186163
703	Phosphorylation	EKLGVMTYSDTGKLS CCCCCEECCCCCCCC	6.10	23186163
704	Phosphorylation	KLGVMTYSDTGKLSP CCCCEECCCCCCCCH	21.38	21815630
706	Phosphorylation	GVMTYSDTGKLSPET CCEECCCCCCCCHHH	30.21	23186163
708	Ubiquitination	MTYSDTGKLSPETQS EECCCCCCCCHHHHH	48.13	22817900
708	Acetylation	MTYSDTGKLSPETQS EECCCCCCCCHHHHH	48.13	25953088
708 (in isoform 1)	Ubiquitination	-	48.13	21890473
710	Phosphorylation	YSDTGKLSPETQSAI CCCCCCCCHHHHHHH	24.95	-
711	Ubiquitination	SDTGKLSPETQSAIE CCCCCCCHHHHHHHH	60.12	29967540
737	Ubiquitination	ERAKHILKTHAKEHK HHHHHHHHHHHHHCC	37.35	29967540
744	Ubiquitination	KTHAKEHKNLAEALL HHHHHHCCCHHHHHH	55.54	29967540
753	Phosphorylation	LAEALLTYETLDAKE HHHHHHHHHHCCHHH	13.59	27642862
768	Ubiquitination	IQIVLEGKKLEVR-- EEEEECCEECEEC--	44.82	29967540
768	2-Hydroxyisobutyrylation	IQIVLEGKKLEVR-- EEEEECCEECEEC--	44.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YMEL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YMEL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YMEL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COX2_HUMAN	COX2	physical	22262461
NDUB6_HUMAN	NDUFB6	physical	22262461
NU5M_HUMAN	ND5	physical	22262461
NU2M_HUMAN	ND2	physical	22262461
NU6M_HUMAN	ND6	physical	22262461
ATPA_HUMAN	ATP5A1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-237, AND MASS SPECTROMETRY.
PubMed: 19608861