NU2M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU2M_HUMAN
• UniProt AC: P03891
• Protein Name: NADH-ubiquinone oxidoreductase chain 2
• Gene Name: MT-ND2
• Organism: Homo sapiens (Human).
• Sequence Length: 347
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
258	Phosphorylation	LGGLPPLTGFLPKWA CCCCCCCCCCCCCHH	31.49	22817900
298	Phosphorylation	YFYLRLIYSTSITLL HHHHHHHHHCCCEEE	15.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU2M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU2M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU2M_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC_HUMAN	SRC	physical	15069201
NMDZ1_HUMAN	GRIN1	physical	15069201

Drug and Disease Associations

• Kegg Disease
• H00068: Leber optic atrophy; Leber hereditary optic atrophy (LHON)
• OMIM Disease
• 535000: Leber hereditary optic neuropathy (LHON)
• 502500: Alzheimer disease mitochondrial (AD-MT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-258, AND MASSSPECTROMETRY.
PubMed: 19690332