TRXR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRXR2_HUMAN
• UniProt AC: Q9NNW7
• Protein Name: Thioredoxin reductase 2, mitochondrial
• Gene Name: TXNRD2
• Organism: Homo sapiens (Human).
• Sequence Length: 524
• Subcellular Localization: Mitochondrion .
• Protein Description: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling..
• Protein Sequence: MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GGRFRWRTQAVAGGV CCCCHHHHHHHHCCH	17.58	24114839
40	Phosphorylation	AAAGQRDYDLLVVGG HHCCCCCCEEEEECC	15.64	20068231
49	Phosphorylation	LLVVGGGSGGLACAK EEEECCCCCHHHHHH	32.72	20068231
56	Acetylation	SGGLACAKEAAQLGR CCHHHHHHHHHHCCC	48.01	25038526
70	Phosphorylation	RKVAVVDYVEPSPQG CCEEEEEEEECCCCC	8.63	-
94	Ubiquitination	VNVGCIPKKLMHQAA EECCCCCHHHHHHHH	38.33	-
137	Acetylation	EAVQNHVKSLNWGHR HHHHHHHHHCCCCCC	41.49	23236377
138	Phosphorylation	AVQNHVKSLNWGHRV HHHHHHHHCCCCCCC	26.33	24702127
153	Acetylation	QLQDRKVKYFNIKAS EECCCEEEEEEEEEE	47.35	25825284
153	Malonylation	QLQDRKVKYFNIKAS EECCCEEEEEEEEEE	47.35	26320211
172	Malonylation	HTVCGVAKGGKEILL CCEEEEEECCCEEEE	66.83	26320211
172	Acetylation	HTVCGVAKGGKEILL CCEEEEEECCCEEEE	66.83	26051181
172	Succinylation	HTVCGVAKGGKEILL CCEEEEEECCCEEEE	66.83	27452117
175	Succinylation	CGVAKGGKEILLSAD EEEEECCCEEEECCC	50.69	-
175	Succinylation	CGVAKGGKEILLSAD EEEEECCCEEEECCC	50.69	-
175	Acetylation	CGVAKGGKEILLSAD EEEEECCCEEEECCC	50.69	20167786
180	Phosphorylation	GGKEILLSADHIIIA CCCEEEECCCEEEEE	28.36	24719451
215	Acetylation	SDDIFWLKESPGKTL CCCEEEEECCCCCEE	46.90	25038526
238	Phosphorylation	LECAGFLTGIGLDTT HHHHHHHHCCCCCCC	25.21	-
244	Phosphorylation	LTGIGLDTTIMMRSI HHCCCCCCCHHHCCC	24.22	-
245	Phosphorylation	TGIGLDTTIMMRSIP HCCCCCCCHHHCCCC	13.42	-
250	Phosphorylation	DTTIMMRSIPLRGFD CCCHHHCCCCCCCCC	15.63	24719451
303 (in isoform 2)	Ubiquitination	-	50.77	-
314 (in isoform 2)	Ubiquitination	-	4.98	-
324	Phosphorylation	GRVPDTRSLNLEKAG CCCCCCCCCCHHHCC	24.57	24719451
329	Succinylation	TRSLNLEKAGVDTSP CCCCCHHHCCCCCCC	54.31	-
329	Succinylation	TRSLNLEKAGVDTSP CCCCCHHHCCCCCCC	54.31	-
334	Phosphorylation	LEKAGVDTSPDTQKI HHHCCCCCCCCCCEE	39.49	25262027
335	Phosphorylation	EKAGVDTSPDTQKIL HHCCCCCCCCCCEEE	19.13	21815630
338	Phosphorylation	GVDTSPDTQKILVDS CCCCCCCCCEEEECC	34.84	25262027
432	Acetylation	EVYHAHYKPLEFTVA EEEECCCCCEEEEEC	33.01	26051181
506	Acetylation	TCSEEVVKLRISKRS CCCHHHHHHHHHCCC	36.90	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRXR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRXR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRXR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS6A_HUMAN	PSMC3	physical	11463857
NCOR1_HUMAN	NCOR1	physical	11463857
NCOA2_HUMAN	NCOA2	physical	12612084
TF2H1_HUMAN	GTF2H1	physical	15625236
ALDR_HUMAN	AKR1B1	physical	26344197
TRXR1_HUMAN	TXNRD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-153, AND MASS SPECTROMETRY.
PubMed: 19608861