| UniProt ID | S22AK_HUMAN | |
|---|---|---|
| UniProt AC | A6NK97 | |
| Protein Name | Solute carrier family 22 member 20 | |
| Gene Name | SLC22A20P {ECO:0000312|HGNC:HGNC:29867} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 555 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).. | |
| Protein Sequence | MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTNDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEEISLQQLRASPLKETI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 54 | N-linked_Glycosylation | HHCRGPANHTEASTN HHCCCCCCCCCCCCC | 45.83 | UniProtKB CARBOHYD | |
| 114 | N-linked_Glycosylation | CKDGWVYNRSVFPST CCCCEEECCCCCCCE | 21.82 | UniProtKB CARBOHYD | |
| 141 | Phosphorylation | TLRDLAQSVYMAGVL HHHHHHHHHHHHHHH | 15.03 | 27174698 | |
| 143 | Phosphorylation | RDLAQSVYMAGVLVG HHHHHHHHHHHHHHH | 6.11 | 27174698 | |
| 156 | Phosphorylation | VGAAVFGSLADRLGC HHHHHHHHHHHHHCC | 14.66 | 27174698 | |
| 311 (in isoform 2) | Phosphorylation | - | 2.00 | - | |
| 334 (in isoform 2) | Phosphorylation | - | 15.11 | 22210691 | |
| 342 (in isoform 2) | Phosphorylation | - | 1.55 | 22210691 | |
| 343 (in isoform 2) | Phosphorylation | - | 1.68 | 22210691 | |
| 370 | Phosphorylation | QKFGLSLYLVQALFG HHHCHHHHHHHHHHH | 11.05 | 18083107 | |
| 393 | Phosphorylation | VATATMIYVGRRATV HHHHHHHHHHCHHHH | 5.99 | 18083107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S22AK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S22AK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S22AK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S22AK_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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