| UniProt ID | OXA1L_HUMAN | |
|---|---|---|
| UniProt AC | Q15070 | |
| Protein Name | Mitochondrial inner membrane protein OXA1L | |
| Gene Name | OXA1L | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 435 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein . |
|
| Protein Description | Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria.. | |
| Protein Sequence | MAMGLMCGRRELLRLLQSGRRVHSVAGPSQWLGKPLTTRLLFPVAPCCCRPHYLFLAASGPRSLSTSAISFAEVQVQAPPVVAATPSPTAVPEVASGETADVVQTAAEQSFAELGLGSYTPVGLIQNLLEFMHVDLGLPWWGAIAACTVFARCLIFPLIVTGQREAARIHNHLPEIQKFSSRIREAKLAGDHIEYYKASSEMALYQKKHGIKLYKPLILPVTQAPIFISFFIALREMANLPVPSLQTGGLWWFQDLTVSDPIYILPLAVTATMWAVLELGAETGVQSSDLQWMRNVIRMMPLITLPITMHFPTAVFMYWLSSNLFSLVQVSCLRIPAVRTVLKIPQRVVHDLDKLPPREGFLESFKKGWKNAEMTRQLREREQRMRNQLELAARGPLRQTFTHNPLLQPGKDNPPNIPSSSSKPKSKYPWHDTLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | ELLRLLQSGRRVHSV HHHHHHHHCCCCEEC | 33.95 | 20860994 | |
| 20 | Phosphorylation | LRLLQSGRRVHSVAG HHHHHHCCCCEECCC | 42.57 | 24719451 | |
| 162 (in isoform 2) | Ubiquitination | - | 17.41 | 21890473 | |
| 176 (in isoform 3) | Ubiquitination | - | 5.22 | 21890473 | |
| 178 | Ubiquitination | NHLPEIQKFSSRIRE HCHHHHHHHHHHHHH | 53.53 | 21890473 | |
| 187 | 2-Hydroxyisobutyrylation | SSRIREAKLAGDHIE HHHHHHHHHHCCHHH | 33.83 | - | |
| 187 | Ubiquitination | SSRIREAKLAGDHIE HHHHHHHHHHCCHHH | 33.83 | - | |
| 197 | Ubiquitination | GDHIEYYKASSEMAL CCHHHHEEHHHHHHH | 40.67 | - | |
| 207 | Succinylation | SEMALYQKKHGIKLY HHHHHHHHHHCCCCC | 32.93 | 23954790 | |
| 207 | Acetylation | SEMALYQKKHGIKLY HHHHHHHHHHCCCCC | 32.93 | 26051181 | |
| 207 | Ubiquitination | SEMALYQKKHGIKLY HHHHHHHHHHCCCCC | 32.93 | - | |
| 238 (in isoform 1) | Ubiquitination | - | 15.06 | 21890473 | |
| 238 | Ubiquitination | FIALREMANLPVPSL HHHHHHHCCCCCCCC | 15.06 | - | |
| 247 | Ubiquitination | LPVPSLQTGGLWWFQ CCCCCCCCCCEECEE | 38.21 | - | |
| 257 | Ubiquitination | LWWFQDLTVSDPIYI EECEEECEECCCEEH | 26.67 | - | |
| 340 | Phosphorylation | LRIPAVRTVLKIPQR CCCCHHHHHHHCCHH | 24.48 | - | |
| 343 | Ubiquitination | PAVRTVLKIPQRVVH CHHHHHHHCCHHHHC | 48.26 | - | |
| 364 | Phosphorylation | PREGFLESFKKGWKN CCCCHHHHHHHHHHH | 44.50 | 23401153 | |
| 366 | 2-Hydroxyisobutyrylation | EGFLESFKKGWKNAE CCHHHHHHHHHHHHH | 60.71 | - | |
| 370 | Ubiquitination | ESFKKGWKNAEMTRQ HHHHHHHHHHHHHHH | 55.75 | - | |
| 394 | Methylation | NQLELAARGPLRQTF HHHHHHHHCCCCCCC | 41.47 | 115486107 | |
| 400 | Phosphorylation | ARGPLRQTFTHNPLL HHCCCCCCCCCCCCC | 24.86 | 23917254 | |
| 402 | Phosphorylation | GPLRQTFTHNPLLQP CCCCCCCCCCCCCCC | 24.91 | 23917254 | |
| 403 | Ubiquitination | PLRQTFTHNPLLQPG CCCCCCCCCCCCCCC | 29.71 | - | |
| 414 | Ubiquitination | LQPGKDNPPNIPSSS CCCCCCCCCCCCCCC | 33.19 | - | |
| 424 | Phosphorylation | IPSSSSKPKSKYPWH CCCCCCCCCCCCCCC | 48.37 | - | |
| 426 | Ubiquitination | SSSSKPKSKYPWHDT CCCCCCCCCCCCCCC | 46.05 | - | |
| 430 | Ubiquitination | KPKSKYPWHDTLG-- CCCCCCCCCCCCC-- | 10.01 | - | |
| 454 | Methylation | -------------------------- -------------------------- | - | ||
| 460 | Phosphorylation | -------------------------------- -------------------------------- | - | ||
| 462 | Phosphorylation | ---------------------------------- ---------------------------------- | 27251275 | ||
| 471 | Ubiquitination | ------------------------------------------- ------------------------------------------- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OXA1L_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OXA1L_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OXA1L_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| OXA1L_HUMAN | OXA1L | physical | 20601428 | |
| RM13_HUMAN | MRPL13 | physical | 20601428 | |
| RM20_HUMAN | MRPL20 | physical | 20601428 | |
| RM28_HUMAN | MRPL28 | physical | 20601428 | |
| RM48_HUMAN | MRPL48 | physical | 20601428 | |
| RM49_HUMAN | MRPL49 | physical | 20601428 | |
| RM51_HUMAN | MRPL51 | physical | 20601428 | |
| TOM40_HUMAN | TOMM40 | physical | 22939629 | |
| RM23_HUMAN | MRPL23 | physical | 22939629 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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