RM28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM28_HUMAN
• UniProt AC: Q13084
• Protein Name: 39S ribosomal protein L28, mitochondrial
• Gene Name: MRPL28
• Organism: Homo sapiens (Human).
• Sequence Length: 256
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MPLHKYPVWLWKRLQLREGICSRLPGHYLRSLEEERTPTPVHYRPHGAKFKINPKNGQRERVEDVPIPIYFPPESQRGLWGGEGWILGQIYANNDKLSKRLKKVWKPQLFEREFYSEILDKKFTVTVTMRTLDLIDEAYGLDFYILKTPKEDLCSKFGMDLKRGMLLRLARQDPQLHPEDPERRAAIYDKYKEFAIPEEEAEWVGLTLEEAIEKQRLLEEKDPVPLFKIYVAELIQQLQQQALSEPAVVQKRASGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MPLHKYPVWLWK ---CCCCCCCHHHHH	59.96	21890473
6	Phosphorylation	--MPLHKYPVWLWKR --CCCCCCCHHHHHH	7.71	-
12	Ubiquitination	KYPVWLWKRLQLREG CCCHHHHHHHHHHCC	40.85	21890473
22	Phosphorylation	QLREGICSRLPGHYL HHHCCHHHCCCHHHH	34.63	22210691
28	Phosphorylation	CSRLPGHYLRSLEEE HHCCCHHHHHHHHHC	15.10	27174698
31	Phosphorylation	LPGHYLRSLEEERTP CCHHHHHHHHHCCCC	37.22	27174698
37	Phosphorylation	RSLEEERTPTPVHYR HHHHHCCCCCCCCCC	34.49	28555341
39	Phosphorylation	LEEERTPTPVHYRPH HHHCCCCCCCCCCCC	37.01	22210691
43	Phosphorylation	RTPTPVHYRPHGAKF CCCCCCCCCCCCCCE	26.52	22210691
106	Ubiquitination	KRLKKVWKPQLFERE HHHHHHHCHHHHCHH	26.35	29967540
115	Phosphorylation	QLFEREFYSEILDKK HHHCHHHHHHHHCCC	10.71	20068231
139	Phosphorylation	LDLIDEAYGLDFYIL HHHHHHHHCCCEEEE	19.04	29496907
144	Phosphorylation	EAYGLDFYILKTPKE HHHCCCEEEEECCHH	12.66	29496907
150	Succinylation	FYILKTPKEDLCSKF EEEEECCHHHHHHHH	69.92	23954790
150	2-Hydroxyisobutyrylation	FYILKTPKEDLCSKF EEEEECCHHHHHHHH	69.92	-
162	Ubiquitination	SKFGMDLKRGMLLRL HHHCCCCHHHHHHHH	42.51	-
188	Phosphorylation	PERRAAIYDKYKEFA HHHHHHHHHHHHHHC	11.14	29496907
190	Ubiquitination	RRAAIYDKYKEFAIP HHHHHHHHHHHHCCC	41.05	29967540
214	Ubiquitination	TLEEAIEKQRLLEEK CHHHHHHHHHHHHCC	34.31	29967540
221	2-Hydroxyisobutyrylation	KQRLLEEKDPVPLFK HHHHHHCCCCCCHHH	58.94	-
221	Ubiquitination	KQRLLEEKDPVPLFK HHHHHHCCCCCCHHH	58.94	29967540
221	Acetylation	KQRLLEEKDPVPLFK HHHHHHCCCCCCHHH	58.94	26051181
251	Ubiquitination	SEPAVVQKRASGQ-- CCCHHHHHHHCCC--	38.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM28_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM28_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RM32_HUMAN	MRPL32	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
RT07_HUMAN	MRPS7	physical	22939629
CIKS_HUMAN	TRAF3IP2	physical	25416956
IKZF3_HUMAN	IKZF3	physical	25416956
BANP_HUMAN	BANP	physical	25416956
HMBX1_HUMAN	HMBOX1	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
RM46_HUMAN	MRPL46	physical	26186194
RM09_HUMAN	MRPL9	physical	26186194
RM32_HUMAN	MRPL32	physical	26186194
RM40_HUMAN	MRPL40	physical	26186194
RM03_HUMAN	MRPL3	physical	26186194
RM01_HUMAN	MRPL1	physical	26186194
RM39_HUMAN	MRPL39	physical	26186194
RM22_HUMAN	MRPL22	physical	26186194
RM37_HUMAN	MRPL37	physical	26186194
RM24_HUMAN	MRPL24	physical	26186194
RM49_HUMAN	MRPL49	physical	26186194
RM44_HUMAN	MRPL44	physical	26186194
RM50_HUMAN	MRPL50	physical	26186194
RM38_HUMAN	MRPL38	physical	26186194
RS8_HUMAN	RPS8	physical	26186194
RM27_HUMAN	MRPL27	physical	26186194
RM55_HUMAN	MRPL55	physical	26186194
RM47_HUMAN	MRPL47	physical	26186194
RM16_HUMAN	MRPL16	physical	26186194
RM19_HUMAN	MRPL19	physical	26186194
ROA1_HUMAN	HNRNPA1	physical	26186194
RM15_HUMAN	MRPL15	physical	26186194
ICT1_HUMAN	ICT1	physical	26186194
RM02_HUMAN	MRPL2	physical	26186194
RM13_HUMAN	MRPL13	physical	26186194
RM17_HUMAN	MRPL17	physical	26186194
RM04_HUMAN	MRPL4	physical	26186194
G45IP_HUMAN	GADD45GIP1	physical	26186194
RM30_HUMAN	MRPL30	physical	26186194
RT30_HUMAN	MRPS30	physical	26186194
RM20_HUMAN	MRPL20	physical	26186194
RM14_HUMAN	MRPL14	physical	26186194
RT18A_HUMAN	MRPS18A	physical	26186194
MRM3_HUMAN	RNMTL1	physical	26186194
MASU1_HUMAN	MALSU1	physical	26186194
RT63_HUMAN	MRPL57	physical	26186194
RM34_HUMAN	MRPL34	physical	26186194
APMAP_HUMAN	APMAP	physical	26344197
RM15_HUMAN	MRPL15	physical	26344197
RM03_HUMAN	MRPL3	physical	26344197
RM37_HUMAN	MRPL37	physical	26344197
RM38_HUMAN	MRPL38	physical	26344197
RM39_HUMAN	MRPL39	physical	26344197
RT30_HUMAN	MRPS30	physical	26344197
RT30_HUMAN	MRPS30	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
RM04_HUMAN	MRPL4	physical	28514442
RM39_HUMAN	MRPL39	physical	28514442
RM30_HUMAN	MRPL30	physical	28514442
RM10_HUMAN	MRPL10	physical	28514442
G45IP_HUMAN	GADD45GIP1	physical	28514442
RM38_HUMAN	MRPL38	physical	28514442
ICT1_HUMAN	ICT1	physical	28514442
RM41_HUMAN	MRPL41	physical	28514442
RM03_HUMAN	MRPL3	physical	28514442
ROA1_HUMAN	HNRNPA1	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RM15_HUMAN	MRPL15	physical	28514442
RS8_HUMAN	RPS8	physical	28514442
RM02_HUMAN	MRPL2	physical	28514442
RM40_HUMAN	MRPL40	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
RM01_HUMAN	MRPL1	physical	28514442
RM24_HUMAN	MRPL24	physical	28514442
MASU1_HUMAN	MALSU1	physical	28514442
RM55_HUMAN	MRPL55	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
RM19_HUMAN	MRPL19	physical	28514442
RT63_HUMAN	MRPL57	physical	28514442
MRM3_HUMAN	RNMTL1	physical	28514442
RM44_HUMAN	MRPL44	physical	28514442
RM37_HUMAN	MRPL37	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
RT18A_HUMAN	MRPS18A	physical	28514442
RM09_HUMAN	MRPL9	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.