RM03_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM03_HUMAN
• UniProt AC: P09001
• Protein Name: 39S ribosomal protein L3, mitochondrial
• Gene Name: MRPL3
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MPGWRLLTQVGAQVLGRLGDGLGAALGPGNRTHIWLFVRGLHGKSGTWWDEHLSEENVPFIKQLVSDEDKAQLASKLCPLKDEPWPIHPWEPGSFRVGLIALKLGMMPLWTKDGQKHVVTLLQVQDCHVLKYTSKENCNGKMATLSVGGKTVSRFRKATSILEFYRELGLPPKQTVKIFNITDNAAIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGVMKRWGFKGQPATHGQTKTHRRPGAVATGDIGRVWPGTKMPGKMGNIYRTEYGLKVWRINTKHNIIYVNGSVPGHKNCLVKVKDSKLPAYKDLGKNLPFPTYFPDGDEEELPEDLYDENVCQPGAPSITFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	FVRGLHGKSGTWWDE EEECCCCCCCCCHHH	34.66	23503661
62	Ubiquitination	EENVPFIKQLVSDED CCCCCHHHHHCCHHH	37.65	22817900
70	Ubiquitination	QLVSDEDKAQLASKL HHCCHHHHHHHHHHH	35.66	29967540
76	Ubiquitination	DKAQLASKLCPLKDE HHHHHHHHHCCCCCC	48.80	27667366
81	Acetylation	ASKLCPLKDEPWPIH HHHHCCCCCCCCCCC	45.23	26051181
111	Phosphorylation	LGMMPLWTKDGQKHV HCCCEEECCCCCEEE	27.26	20068231
112	Ubiquitination	GMMPLWTKDGQKHVV CCCEEECCCCCEEEE	48.56	29967540
131	Acetylation	VQDCHVLKYTSKENC EECCEEEEEECCCCC	45.45	26051181
150	Acetylation	ATLSVGGKTVSRFRK EEEEECCEEHHHHHH	39.56	27452117
150	Ubiquitination	ATLSVGGKTVSRFRK EEEEECCEEHHHHHH	39.56	29967540
153	Phosphorylation	SVGGKTVSRFRKATS EECCEEHHHHHHHHH	30.82	-
157	Ubiquitination	KTVSRFRKATSILEF EEHHHHHHHHHHHHH	53.99	24816145
159	Phosphorylation	VSRFRKATSILEFYR HHHHHHHHHHHHHHH	21.23	30108239
160	Phosphorylation	SRFRKATSILEFYRE HHHHHHHHHHHHHHH	30.00	30108239
188	Ubiquitination	ITDNAAIKPGTPLYA ECCCCCCCCCCCEEE	32.44	29967540
209	Ubiquitination	QYVDVTAKTIGKGFQ CEEEEEEEECCCCHH	31.17	29967540
213	Ubiquitination	VTAKTIGKGFQGVMK EEEEECCCCHHHHHH	53.34	-
235	Ubiquitination	PATHGQTKTHRRPGA CCCCCCCCCCCCCCC	34.15	29967540
260	Ubiquitination	PGTKMPGKMGNIYRT CCCCCCCCCCCEEEE	37.45	-
265	Phosphorylation	PGKMGNIYRTEYGLK CCCCCCEEEECCEEE	18.58	-
303	Ubiquitination	LVKVKDSKLPAYKDL EEEECCCCCCCHHCC	69.49	29967540
308	Ubiquitination	DSKLPAYKDLGKNLP CCCCCCHHCCCCCCC	48.89	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM03_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM03_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM03_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RM09_HUMAN	MRPL9	physical	22939629
RM04_HUMAN	MRPL4	physical	22939629
RM12_HUMAN	MRPL12	physical	22939629
RT09_HUMAN	MRPS9	physical	22939629
RM39_HUMAN	MRPL39	physical	22939629
RM23_HUMAN	MRPL23	physical	22939629
RM13_HUMAN	MRPL13	physical	22939629
RM17_HUMAN	MRPL17	physical	22939629
RM10_HUMAN	MRPL10	physical	22939629
RM46_HUMAN	MRPL46	physical	22939629
RM42_HUMAN	MRPL42	physical	22939629
RM55_HUMAN	MRPL55	physical	22939629
RM52_HUMAN	MRPL52	physical	22939629
RM19_HUMAN	MRPL19	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
RS18_HUMAN	RPS18	physical	22939629
RS15_HUMAN	RPS15	physical	22939629
RM15_HUMAN	MRPL15	physical	26344197
RM37_HUMAN	MRPL37	physical	26344197
RM38_HUMAN	MRPL38	physical	26344197
RM09_HUMAN	MRPL9	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614582: Combined oxidative phosphorylation deficiency 9 (COXPD9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.