CIKS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIKS_HUMAN
• UniProt AC: O43734
• Protein Name: Adapter protein CIKS
• Gene Name: TRAF3IP2
• Organism: Homo sapiens (Human).
• Sequence Length: 574
• Protein Description: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK..
• Protein Sequence: MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSLGGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNRAGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPPQLQETRMNRSIP CCHHHHHCCCCCCCC	23.43	22210691
13	Phosphorylation	QETRMNRSIPVEVDE HHCCCCCCCCCCCCC	26.66	27642862
21	Phosphorylation	IPVEVDESEPYPSQL CCCCCCCCCCCHHHH	39.13	27642862
24	Phosphorylation	EVDESEPYPSQLLKP CCCCCCCCHHHHCCC	16.09	27642862
36	Phosphorylation	LKPIPEYSPEEESEP CCCCCCCCCCCCCCC	24.95	25159151
155	Phosphorylation	QWLVSQLSAASPDTG HHHHHHHHHCCCCCC	17.72	28348404
208	Phosphorylation	LPTIDTGYDSQPQDV CCCCCCCCCCCCCCC	17.95	27642862
210	Phosphorylation	TIDTGYDSQPQDVLG CCCCCCCCCCCCCCC	34.96	-
314	Methylation	PLPGASVRGLHPVQK CCCCCCCCCCCCCEE	39.19	115918889
342	Phosphorylation	RPAQRDCSFPGLPRH CCCCCCCCCCCCCCC	38.47	28555341
374	Phosphorylation	SLECPAELRPQVPQP CCCCCHHHCCCCCCC	11.99	27251275
383	Phosphorylation	PQVPQPPSPAAVPRP CCCCCCCCCCCCCCC	33.58	25159151
402	Phosphorylation	PARGTLKTSNLPEEL CCCCCCCCCCCCHHH	26.43	22617229
403	Phosphorylation	ARGTLKTSNLPEELR CCCCCCCCCCCHHHH	34.48	23663014
464	Phosphorylation	ERYLRDKTVMIIVAI HHHHCCCEEEEEEEE	21.42	22798277
472	Phosphorylation	VMIIVAISPKYKQDV EEEEEEECHHHHHCC	12.95	22798277
558	Phosphorylation	RLLREEEYVAPPRGP HHHHHHHCCCCCCCC	12.75	25394399

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIKS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIKS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF3_HUMAN	TRAF3	physical	12089335
TNR5_HUMAN	CD40	physical	12089335
IKKA_HUMAN	CHUK	physical	10962033
IKKB_HUMAN	IKBKB	physical	10962033
UBC_HUMAN	UBC	physical	19825828
TRAF6_HUMAN	TRAF6	physical	19825828
TRAF6_HUMAN	TRAF6	physical	12459498
CIKS_HUMAN	TRAF3IP2	physical	12943667
IKKA_HUMAN	CHUK	physical	12943667
IKKB_HUMAN	IKBKB	physical	12943667
NEMO_HUMAN	IKBKG	physical	12943667
I17RA_HUMAN	IL17RA	physical	17277779
M3K7_HUMAN	MAP3K7	physical	17277779
TRAF6_HUMAN	TRAF6	physical	17277779
TNR5_HUMAN	CD40	physical	15485634
TRAF3_HUMAN	TRAF3	physical	15485634
TRAF2_HUMAN	TRAF2	physical	15485634
TR13C_HUMAN	TNFRSF13C	physical	15485634
TBK1_HUMAN	TBK1	physical	22851696
IKKE_HUMAN	IKBKE	physical	22851696
KSYK_HUMAN	SYK	physical	25202827
I17RA_HUMAN	IL17RA	physical	25202827
TRAF6_HUMAN	TRAF6	physical	25202827
UB2V1_HUMAN	UBE2V1	physical	19825828
ELAV1_HUMAN	ELAVL1	physical	23772036
SRSF1_HUMAN	SRSF1	physical	23772036
RIM3A_HUMAN	RIMBP3	physical	25416956
HS90A_HUMAN	HSP90AA1	physical	25024377
I17RA_HUMAN	IL17RA	physical	24120361
I17RB_HUMAN	IL17RB	physical	24120361
I17RC_HUMAN	IL17RC	physical	24120361
CIKS_HUMAN	TRAF3IP2	physical	24120361
HS90A_HUMAN	HSP90AA1	physical	24120361
HSP74_HUMAN	HSPA4	physical	24120361
TNR5_HUMAN	CD40	physical	24120361
TRAF3_HUMAN	TRAF3	physical	24120361
IKKE_HUMAN	IKBKE	physical	23066157
IRF3_HUMAN	IRF3	physical	23066157
TRAF6_HUMAN	TRAF6	physical	23737552
TRAF5_HUMAN	TRAF5	physical	21822258
SRSF1_HUMAN	SRSF1	physical	21822258
IKKB_HUMAN	IKBKB	physical	24561578
GOGA2_HUMAN	GOLGA2	physical	21516116
TRAF6_HUMAN	TRAF6	physical	21516116
INVS_HUMAN	INVS	physical	27173435
I17RA_HUMAN	IL17RA	physical	28219902

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614070: Psoriasis 13 (PSORS13)
• 615527: Candidiasis, familial, 8 (CANDF8)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.