I17RC_HUMAN - dbPTM
I17RC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID I17RC_HUMAN
UniProt AC Q8NAC3
Protein Name Interleukin-17 receptor C
Gene Name IL17RC
Organism Homo sapiens (Human).
Sequence Length 791
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Soluble isoforms may be produced.
Protein Description Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. [PubMed: 16785495 Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA]
Protein Sequence MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPVSLEPWGDEERLRVQFLAQQSLSLAPVTAATARTALSGLSGADGRREERGRGKSWVCLSLGGSGNTEPQKKGLSCRLWDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKRWALVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGAAARGRAALLLYSADDSGFERLVGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQRRQTLQEGGVVVLLFSPGAVALCSEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFDRLLHPDAVPALFRTVPVFTLPSQLPDFLGALQQPRAPRSGRLQERAEQVSRALQPALDSYFHPPGTPAPGRGVGPGAGPGAGDGT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
109PhosphorylationEPQKKGLSCRLWDSD
CHHHCCCCCEECCCC		13.0827135362
189N-linked_GlycosylationSGVEEPRNASLQAQV
CCCCCCCCCCCEEEE		44.59UniProtKB CARBOHYD
252PhosphorylationWSYTQPRYEKELNHT
EEECCCCHHHHCCCC		37.7322817900
257N-linked_GlycosylationPRYEKELNHTQQLPD
CCHHHHCCCCCCCCC		36.93UniProtKB CARBOHYD
284N-linked_GlycosylationCWALPWLNVSADGDN
CEECCCEEEECCCCE		23.10UniProtKB CARBOHYD
297N-linked_GlycosylationDNVHLVLNVSEEQHF
CEEEEEEECCCHHCC		27.99UniProtKB CARBOHYD
324N-linked_GlycosylationPKPRWHKNLTGPQII
CCCCCCCCCCCCCEE		29.92UniProtKB CARBOHYD
334N-linked_GlycosylationGPQIITLNHTDLVPC
CCCEEECCCCCCEEE		27.62UniProtKB CARBOHYD
420N-linked_GlycosylationVPPLSWENVTVDKVL
CCCCCCCCCCHHEEE		28.62UniProtKB CARBOHYD
443N-linked_GlycosylationPNLCVQVNSSEKLQL
CCEEEEECCCCCEEH		23.79UniProtKB CARBOHYD
456UbiquitinationQLQECLWADSLGPLK
EHHHHHHHHCCCCCC		5.4221890473
462UbiquitinationWADSLGPLKDDVLLL
HHHCCCCCCCCEEEE		10.1021890473
469UbiquitinationLKDDVLLLETRGPQD
CCCCEEEEECCCCCC		5.7421890473
474UbiquitinationLLLETRGPQDNRSLC
EEEECCCCCCCCCCE		34.7521890473
476UbiquitinationLETRGPQDNRSLCAL
EECCCCCCCCCCEEE		56.4921890473
477N-linked_GlycosylationETRGPQDNRSLCALE
ECCCCCCCCCCEEEC		30.14UniProtKB CARBOHYD
477UbiquitinationETRGPQDNRSLCALE
ECCCCCCCCCCEEEC		30.1421890473
486 (in isoform 3)Ubiquitination-36.8121890473
486 (in isoform 4)Ubiquitination-36.8121890473
486UbiquitinationSLCALEPSGCTSLPS
CCEEECCCCCCCCCC		36.8121890473
487UbiquitinationLCALEPSGCTSLPSK
CEEECCCCCCCCCCH		29.4521890473
493PhosphorylationSGCTSLPSKASTRAA
CCCCCCCCHHHHHHH		46.2624719451
501 (in isoform 2)Ubiquitination-42.0921890473
501UbiquitinationKASTRAARLGEYLLQ
HHHHHHHHHHHHHHH		42.0921890473
502UbiquitinationASTRAARLGEYLLQD
HHHHHHHHHHHHHHH		5.3921890473
505PhosphorylationRAARLGEYLLQDLQS
HHHHHHHHHHHHCCC		15.77-
512PhosphorylationYLLQDLQSGQCLQLW
HHHHHCCCCCCEEEE		37.82-
533UbiquitinationLWACPMDKYIHKRWA
HHCCCHHHHHHHHHH		39.5921890473
537 (in isoform 4)Phosphorylation-39.8222210691
544UbiquitinationKRWALVWLACLLFAA
HHHHHHHHHHHHHHH		1.5621890473
548UbiquitinationLVWLACLLFAAALSL
HHHHHHHHHHHHHHH		2.4921890473
555UbiquitinationLFAAALSLILLLKKD
HHHHHHHHHHHHHCH		3.1321890473
557UbiquitinationAAALSLILLLKKDHA
HHHHHHHHHHHCHHH		5.7821890473
558UbiquitinationAALSLILLLKKDHAK
HHHHHHHHHHCHHHH		5.3721890473
559UbiquitinationALSLILLLKKDHAKG
HHHHHHHHHCHHHHH		6.0921890473
560UbiquitinationLSLILLLKKDHAKGW
HHHHHHHHCHHHHHH		57.0021890473
572UbiquitinationKGWLRLLKQDVRSGA
HHHHHHHHHHHHHCH		49.3922817900
572 (in isoform 1)Ubiquitination-49.3921890473
573UbiquitinationGWLRLLKQDVRSGAA
HHHHHHHHHHHHCHH		55.1721890473
772PhosphorylationSYFHPPGTPAPGRGV
HHCCCCCCCCCCCCC		23.2723186163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of I17RC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of I17RC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of I17RC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AT2A3_HUMANATP2A3physical
28514442
KCNT2_HUMANKCNT2physical
28514442
KCJ11_HUMANKCNJ11physical
28514442
GMCL1_HUMANGMCL1physical
28514442
DHRS3_HUMANDHRS3physical
28514442
ADCK2_HUMANADCK2physical
28514442
PIGQ_HUMANPIGQphysical
28514442
S12A4_HUMANSLC12A4physical
28514442
LRP12_HUMANLRP12physical
28514442
ADCY3_HUMANADCY3physical
28514442
ECEL1_HUMANECEL1physical
28514442
ABCA3_HUMANABCA3physical
28514442
AVR2B_HUMANACVR2Bphysical
28514442
M3K7_HUMANMAP3K7physical
28514442
HMR1_HUMANMR1physical
28514442
CA043_HUMANC1orf43physical
28514442
TYW1_HUMANTYW1physical
28514442
PDE3B_HUMANPDE3Bphysical
28514442
ENPP4_HUMANENPP4physical
28514442
PLXB2_HUMANPLXNB2physical
28514442
C2C2L_HUMANC2CD2Lphysical
28514442
EPHB4_HUMANEPHB4physical
28514442
AMZ2_HUMANAMZ2physical
28514442
TAB2_HUMANTAB2physical
28514442
MANEL_HUMANMANEALphysical
28514442
ALG9_HUMANALG9physical
28514442
FA69A_HUMANFAM69Aphysical
28514442
SRBP2_HUMANSREBF2physical
28514442
LARG2_HUMANGYLTL1Bphysical
28514442
DISP1_HUMANDISP1physical
28514442
PDZD8_HUMANPDZD8physical
28514442
BAG6_HUMANBAG6physical
28514442
NPC1_HUMANNPC1physical
28514442
EPHA7_HUMANEPHA7physical
28514442
FADS1_HUMANFADS1physical
28514442
TM39A_HUMANTMEM39Aphysical
28514442
ARL8B_HUMANARL8Bphysical
28514442
BI1_HUMANTMBIM6physical
28514442
ABHD3_HUMANABHD3physical
28514442
MBTP2_HUMANMBTPS2physical
28514442
HERC3_HUMANHERC3physical
28514442
ITA7_HUMANITGA7physical
28514442
GET4_HUMANGET4physical
28514442
HSP7C_HUMANHSPA8physical
28514442
MA2A2_HUMANMAN2A2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616445Candidiasis, familial, 9 (CANDF9)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of I17RC_HUMAN

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Related Literatures of Post-Translational Modification

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