DISP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DISP1_HUMAN
• UniProt AC: Q96F81
• Protein Name: Protein dispatched homolog 1
• Gene Name: DISP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1524
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion. [PubMed: 22902404]
• Protein Sequence: MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNGTVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASHSCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHTVCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQAVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRSIEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVELSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPNMEANVPAVLTHSELSGESLLIKTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	EATRTKVSPNGCLQL CCCCCCCCCCCCEEE	17.76	25159151
59	N-linked_Glycosylation	PNGCLQLNGTVKSSF CCCCEEECCEEEECC	31.00	UniProtKB CARBOHYD
65	Phosphorylation	LNGTVKSSFLPLDNQ ECCEEEECCCCCCCC	25.70	28555341
249	Phosphorylation	KNTGYKATLANYPFK CCCCCCEEECCCCCC	23.42	-
290	Phosphorylation	DWNFHKDSFFCDVPS CCCCCCCCCEEECCC	25.65	-
412	Phosphorylation	RKDQLKCTNVPRKCT CHHHHHCCCCCCCCC	37.35	26074081
582	N-linked_Glycosylation	FVLCDVWNYTKFDKP HHCCHHHCCCCCCCC	34.15	UniProtKB CARBOHYD
678	Phosphorylation	KKPQQQIYDNKSCWT CCCCHHHCCCCCHHH	14.77	27642862
811	Phosphorylation	PKSKGKLTLDSSFNI CCCCCCEEECCCCCC	31.82	-
1155	Phosphorylation	KLQCSAFSHALSTSP HHCCCCCCCCCCCCC	13.94	-
1159	Phosphorylation	SAFSHALSTSPSDKG CCCCCCCCCCCCCCC	27.85	29514088
1160	Phosphorylation	AFSHALSTSPSDKGQ CCCCCCCCCCCCCCC	45.57	25159151
1161	Phosphorylation	FSHALSTSPSDKGQS CCCCCCCCCCCCCCC	21.02	25159151
1163	Phosphorylation	HALSTSPSDKGQSKT CCCCCCCCCCCCCCE	52.28	29514088
1168	Phosphorylation	SPSDKGQSKTHTINA CCCCCCCCCEEEEEE	48.46	-
1170	Phosphorylation	SDKGQSKTHTINAYH CCCCCCCEEEEEEEE	29.51	29449344
1172	Phosphorylation	KGQSKTHTINAYHLD CCCCCEEEEEEEECC	22.59	28555341
1176	Phosphorylation	KTHTINAYHLDPRGP CEEEEEEEECCCCCC	9.83	27642862
1184	Ubiquitination	HLDPRGPKSELEHEF ECCCCCCHHHHCCEE	60.43	29967540
1185	Phosphorylation	LDPRGPKSELEHEFY CCCCCCHHHHCCEEE	51.01	27642862
1192	Phosphorylation	SELEHEFYELEPLAS HHHCCEEEECCCCCC	19.33	27642862
1210	Phosphorylation	TAPEKTTYEETHICS CCCCCCCCCCCCCHH	19.59	27642862
1235	Phosphorylation	GMPVHAAYNSELSKS CCCHHHHHCCCCCCC	21.72	27642862
1350	Phosphorylation	KPAGMQNSLPRNFFL CCCCCCCCCCCCCCC	23.90	28857561
1371	Ubiquitination	QAQEKIGKTNVHSLQ HHHHHHCCCCHHHHH	40.16	29967540
1372	Phosphorylation	AQEKIGKTNVHSLQR HHHHHCCCCHHHHHH	36.94	27251275
1376	Phosphorylation	IGKTNVHSLQRSIEE HCCCCHHHHHHHHHH	23.16	27251275
1380	Phosphorylation	NVHSLQRSIEEHLPK CHHHHHHHHHHHCCH	22.76	25850435
1392	Phosphorylation	LPKMAEPSSFVCRST CCHHCCCCCEEECCC	28.10	27251275
1393	Phosphorylation	PKMAEPSSFVCRSTG CHHCCCCCEEECCCC	32.20	27251275
1398	Phosphorylation	PSSFVCRSTGSLLKT CCCEEECCCCHHHHH	31.80	23312004
1399	Phosphorylation	SSFVCRSTGSLLKTC CCEEECCCCHHHHHH	16.07	22210691
1401	Phosphorylation	FVCRSTGSLLKTCCD EEECCCCHHHHHHCC	30.53	22210691
1428	Phosphorylation	DVSNLESSGGTENKA CCCCCCCCCCCCCCC	31.69	28674419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DISP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DISP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DISP1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DISP1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.