PIGQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIGQ_HUMAN
• UniProt AC: Q9BRB3
• Protein Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
• Gene Name: PIGQ
• Organism: Homo sapiens (Human).
• Sequence Length: 760
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis..
• Protein Sequence: MVLKAFFPTCCVSTDSGLLVGRWVPEQSSAVVLAVLHFPFIPIQVKQLLAQVRQASQVGVAVLGTWCHCRQEPEESLGRFLESLGAVFPHEPWLRLCRERGGTFWSCEATHRQAPTAPGAPGEDQVMLIFYDQRQVLLSQLHLPTVLPDRQAGATTASTGGLAAVFDTVARSEVLFRSDRFDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSAVSACRVFKLWPLSFLGSKLSTCEQLRHRLEHLTLIFSTRKAENPAQLMRKANTVASVLLDVALGLMLLSWLHGRSRIGHLADALVPVADHVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFVEHILWHVGLSACLGLTVALSLLSDIIALLTFHIYCFYVYGARLYCLKIHGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILLFLLPTTALYYLVFTLLRLLVVAVQGLIHLLVDLINSLPLYSLGLRLCRPYRLADKPTALQPRGAHLPPPQLWLPPQALLGRPVPQAVPWGAHLPLEAERGQAGLRELLARLAPPHGHSQPSALPGWHQLSWRMSCALWTLLCAPEHGRPCYHTLGLEVIGSEQMWGWPARLAALHHWHCLPWDPLPTCCGHHGGEHSNPRCPEHCPMPTLCTQVQRVRPPQQPQVEGWSPWGLPSGSALAVGVEGPCQDEPPSPRHPLAPSAEQHPASGGLKQSLTPVPSGPGPSLPEPHGVYLRMFPGEVAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	LAQVRQASQVGVAVL HHHHHHHHHHCCEEE	19.63	26126808
65	Phosphorylation	VGVAVLGTWCHCRQE HCCEEEECCCCCCCC	22.28	26126808
76	Phosphorylation	CRQEPEESLGRFLES CCCCHHHHHHHHHHH	34.17	26126808
265	Ubiquitination	TLIFSTRKAENPAQL HHHEECCCCCCHHHH	61.20	-
419	Phosphorylation	LKIHGLSSLWRLFRG HHHCCHHHHHHHHCC	36.67	24719451
563 (in isoform 2)	Ubiquitination	-	53.85	21890473
587	Phosphorylation	LPGWHQLSWRMSCAL CCCHHHHHHHHHHHH	13.18	24719451
731	Phosphorylation	ASGGLKQSLTPVPSG CCCCCCCCCCCCCCC	32.40	30206219
733	Phosphorylation	GGLKQSLTPVPSGPG CCCCCCCCCCCCCCC	27.73	30206219
737	Phosphorylation	QSLTPVPSGPGPSLP CCCCCCCCCCCCCCC	58.83	30206219
742	Phosphorylation	VPSGPGPSLPEPHGV CCCCCCCCCCCCCCE	63.57	30206219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIGQ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIGQ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIGQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIGH_HUMAN	PIGH	physical	9463366
PIGC_HUMAN	PIGC	physical	9463366
PIGA_HUMAN	PIGA	physical	9463366

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.