PIGH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIGH_HUMAN
• UniProt AC: Q14442
• Protein Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
• Gene Name: PIGH
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Subcellular Localization: Cytoplasm.
• Protein Description: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis..
• Protein Sequence: MEDERSFSDICGGRLALQRRYYSPSCREFCLSCPRLSLRSLTAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDQETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDIVINEAIYMQKVIYYLCILLKDPVEPHGISQVVPVFQSAKPRLDCLIEVYRSCQEILAHQKATSTSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEDERSFSDICGG --CCCCCCHHHHHCH	27.36	21815630
37	Phosphorylation	CLSCPRLSLRSLTAV HHHCCHHCHHHHHHH	24.02	23532336
42	Phosphorylation	RLSLRSLTAVTCTVW HHCHHHHHHHHHHHH	21.96	-
45	Phosphorylation	LRSLTAVTCTVWLAA HHHHHHHHHHHHHHH	10.45	-
118	Ubiquitination	TTFIEMGKVKDIVIN EEEEECCCEEEEEEC	44.81	27667366
181	Ubiquitination	CQEILAHQKATSTSP HHHHHHHHHHCCCCC	31.32	22505724
182	Ubiquitination	QEILAHQKATSTSP- HHHHHHHHHCCCCC-	43.71	22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIGH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIGH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIGH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIGA_HUMAN	PIGA	physical	8900170

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.
PubMed: 18691976