MBTP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBTP2_HUMAN
• UniProt AC: O43462
• Protein Name: Membrane-bound transcription factor site-2 protease
• Gene Name: MBTPS2
• Organism: Homo sapiens (Human).
• Sequence Length: 519
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cytoplasm .
• Protein Description: Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop..
• Protein Sequence: MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRTNKDCKKSSSSSFCIIPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVVVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Ubiquitination	LKSSVYFKHSYEDWL HHCCEEECCCHHHHH	17.60	21963094
44	Phosphorylation	WLENNGLSISPFHIR HHHHCCCCCCCCEEC	23.55	30206219
46	Phosphorylation	ENNGLSISPFHIRWQ HHCCCCCCCCEECCC	20.38	30206219
116	Phosphorylation	SPSSYSSSSSSSSSS CCCCCCCCCCCCCCC	28.44	-
117	Phosphorylation	PSSYSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
118	Phosphorylation	SSYSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
119	Phosphorylation	SYSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
120	Phosphorylation	YSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
121	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
122	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
123	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
124	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
125	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
126	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
127	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
128	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
129	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
265	Phosphorylation	ITEVAEDSPAIGPRG HEECCCCCCCCCCCC	14.03	-
332	Phosphorylation	YKRLDGSTECCNNHS EECCCCCCCCCCCCC	38.27	30576142
337	N-linked_Glycosylation	GSTECCNNHSLTDVC CCCCCCCCCCCCHHH	16.53	10419520
339	Phosphorylation	TECCNNHSLTDVCFS CCCCCCCCCCHHHHH	34.78	30576142
341	Phosphorylation	CCNNHSLTDVCFSYR CCCCCCCCHHHHHHC	29.42	30576142
346	Phosphorylation	SLTDVCFSYRNNFNK CCCHHHHHHCCCCCH	20.32	30576142
347	Phosphorylation	LTDVCFSYRNNFNKR CCHHHHHHCCCCCHH	9.34	30576142
353	Ubiquitination	SYRNNFNKRLHTCLP HHCCCCCHHHHHHCH	52.80	27667366
363	Ubiquitination	HTCLPARKAVEATQV HHHCHHHHHHHHHHH	59.91	29967540
379	Ubiquitination	RTNKDCKKSSSSSFC CCCCCCCCCCCCCEE	63.00	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBTP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBTP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBTP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYVN1_HUMAN	SYVN1	physical	26186194
SARAF_HUMAN	SARAF	physical	26186194
FA8A1_HUMAN	FAM8A1	physical	26186194
SARAF_HUMAN	SARAF	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00740: Ichthyosis follicularis, alopecia, and photophobia syndrome
• H00750: Keratosis follicularis spinulosa decalvans
• OMIM Disease
• 308205: IFAP syndrome with or without BRESHECK syndrome (IFAPS)
• 300918: Olmsted syndrome, X-linked (OLMSX)
• 308800: Keratosis follicularis spinulosa decalvans X-linked (KFSDX)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Membrane topology of S2P, a protein required for intramembranouscleavage of sterol regulatory element-binding proteins.";
Zelenski N.G., Rawson R.B., Brown M.S., Goldstein J.L.;
J. Biol. Chem. 274:21973-21980(1999).
Cited for: TOPOLOGY, AND GLYCOSYLATION AT ASN-337.
PubMed: 10419520