| UniProt ID | ADCK2_HUMAN | |
|---|---|---|
| UniProt AC | Q7Z695 | |
| Protein Name | Uncharacterized aarF domain-containing protein kinase 2 | |
| Gene Name | ADCK2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 626 | |
| Subcellular Localization |
Membrane Single-pass membrane protein . |
|
| Protein Description | The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).. | |
| Protein Sequence | MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVLSRRRVRCSGAAGAGPAESLPRAGPLGGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLWLHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNGRKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQIDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGNILVQGANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQGQRVAELILHHARASECRDVEGFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKVKLESNFASIVFAIMVLEGLGRSLDPKLDILEAARPFLLTGPVCPP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 218 | Phosphorylation | VAQVYKAYANTAFLE HHHHHHHHHCCCEEC | 9.02 | 46159551 | |
| 262 | Ubiquitination | GYLGNGRKPPENLAD CCCCCCCCCCCCCCC | 67.34 | - | |
| 271 | Phosphorylation | PENLADQSFLERLLL CCCCCCHHHHHHHHC | 32.14 | 29255136 | |
| 280 | Ubiquitination | LERLLLPKADLVGSN HHHHHCCHHHHCCCC | 55.28 | - | |
| 387 | Phosphorylation | VKAVKFPTPLRPFVT EEEEECCCCCCCCCC | 37.78 | 46159545 | |
| 421 | Ubiquitination | AGIPVDLKRKIARLG CCCCCCHHHHHHHHC | 47.37 | - | |
| 566 | Phosphorylation | TLEKLHVSSLLSSVF CHHHHHHHHHHHHHH | 12.43 | 22468782 | |
| 570 | Phosphorylation | LHVSSLLSSVFKLLM HHHHHHHHHHHHHHH | 29.74 | 22468782 | |
| 571 | Phosphorylation | HVSSLLSSVFKLLMT HHHHHHHHHHHHHHH | 31.38 | 22468782 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ADCK2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADCK2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADCK2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ADCK2_HUMAN | ADCK2 | physical | 27499296 | |
| PDK2_HUMAN | PDK2 | physical | 27499296 | |
| STML2_HUMAN | STOML2 | physical | 27499296 | |
| G6PI_HUMAN | GPI | physical | 27499296 | |
| MPPB_HUMAN | PMPCB | physical | 27499296 | |
| NRDC_HUMAN | NRD1 | physical | 27499296 | |
| CLPB_HUMAN | CLPB | physical | 27499296 | |
| RM22_HUMAN | MRPL22 | physical | 27499296 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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