KCNT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNT2_HUMAN
• UniProt AC: Q6UVM3
• Protein Name: Potassium channel subfamily T member 2
• Gene Name: KCNT2
• Organism: Homo sapiens (Human).
• Sequence Length: 1135
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1..
• Protein Sequence: MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLENPSQGNEWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRSASGPTLSLPTEGSKEIRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRIELNDVVYLIRPDPLAYLPNSEPSRRNSICNVTGQDSREETQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVDLESEVPPLPP --CCCCCCCCCCCCC	51.71	28387310
58	Phosphorylation	FFIKNQRSSLRIRLF EEECCCCCCHHHHHH	24.78	28634120
59	Phosphorylation	FIKNQRSSLRIRLFN EECCCCCCHHHHHHH	24.69	23312004
73	Phosphorylation	NFSLKLLSCLLYIIR HHHHHHHHHHHHHHH	17.10	26270265
77	Phosphorylation	KLLSCLLYIIRVLLE HHHHHHHHHHHHHHH	4.95	26270265
99	N-linked_Glycosylation	WSHIFWVNRSLPLWG CEEEEEEECCCCCHH	20.58	UniProtKB CARBOHYD
354	Phosphorylation	VLQIPMWSQRVIYLQ HHCCCCCCCEEEEEE	11.23	22210691
366 (in isoform 2)	Ubiquitination	-	53.73	-
385	Phosphorylation	AEACFILSSRCEVDR HHHHEEEECCCEECC	15.77	24719451
386	Phosphorylation	EACFILSSRCEVDRT HHHEEEECCCEECCC	37.19	24719451
479 (in isoform 2)	Ubiquitination	-	31.00	-
518	Ubiquitination	ASFHAHKKFGVCLIG EEEECHHHHCEEEEE	37.17	-
702	Phosphorylation	CCLRLDKSCQHNYYE EEEECCCCCCCCHHH	20.76	29449344
707	Phosphorylation	DKSCQHNYYEDAKAY CCCCCCCHHHHHHHC	13.20	29449344
708	Phosphorylation	KSCQHNYYEDAKAYG CCCCCCHHHHHHHCC	16.79	29449344
793	Phosphorylation	DLLRCGVTFAANMVV HHHHCCCEEEECEEE	7.89	22210691
806	Phosphorylation	VVVDKESTMSAEEDY EEECCHHCCCCCHHH	19.08	22210691
808	Phosphorylation	VDKESTMSAEEDYMA ECCHHCCCCCHHHHC	32.39	22210691
813	Phosphorylation	TMSAEEDYMADAKTI CCCCCHHHHCCHHHH	9.47	22210691
819	Phosphorylation	DYMADAKTIVNVQTL HHHCCHHHHCHHHHH	31.70	27174698
825	Phosphorylation	KTIVNVQTLFRLFSS HHHCHHHHHHHHHHH	24.47	27174698
831	Phosphorylation	QTLFRLFSSLSIITE HHHHHHHHHHHHHHH	34.65	27174698
832	Phosphorylation	TLFRLFSSLSIITEL HHHHHHHHHHHHHHC	20.85	27174698
834	Phosphorylation	FRLFSSLSIITELTH HHHHHHHHHHHHCCC	17.56	27174698
837	Phosphorylation	FSSLSIITELTHPAN HHHHHHHHHCCCHHH	24.23	27174698
840	Phosphorylation	LSIITELTHPANMRF HHHHHHCCCHHHCCC	21.41	27174698
856	Phosphorylation	QFRAKDCYSLALSKL HHHHHHHHHHHHHHH	19.49	22817900
861	Phosphorylation	DCYSLALSKLEKKER HHHHHHHHHHHHHHH	29.59	22817900
900	Phosphorylation	LDTLLYQSFVKDYMI HHHHHHHHHHHHHHH	20.60	24425749
908	Phosphorylation	FVKDYMISITRLLLG HHHHHHHHHHHHHHC	11.02	24719451
919	Phosphorylation	LLLGLDTTPGSGFLC HHHCCCCCCCCCCCC	25.89	24719451
922	Phosphorylation	GLDTTPGSGFLCSMK CCCCCCCCCCCCCCE	27.81	24719451
1113	Phosphorylation	PLAYLPNSEPSRRNS CCCCCCCCCCCCCCC	49.28	27732954
1116	Phosphorylation	YLPNSEPSRRNSICN CCCCCCCCCCCCCCC	39.56	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNT2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNT2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.