CA043_HUMAN - dbPTM
CA043_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CA043_HUMAN
UniProt AC Q9BWL3
Protein Name Uncharacterized protein C1orf43
Gene Name C1orf43
Organism Homo sapiens (Human).
Sequence Length 253
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description
Protein Sequence MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRTSEIPFHSEGRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDGYETARYGTGVFGQNEYLRYQEALSELATAVKARIGSSQRHHQSAAKDLTQSPEVSPTTIQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39 (in isoform 2)Ubiquitination-8.3021906983
39 (in isoform 4)Ubiquitination-8.3021906983
56UbiquitinationPVGHNAPKDLKEEID
CCCCCCCCCHHHHHH		73.59-
59SumoylationHNAPKDLKEEIDIRL
CCCCCCHHHHHHHCH		64.53-
59SumoylationHNAPKDLKEEIDIRL
CCCCCCHHHHHHHCH		64.53-
59UbiquitinationHNAPKDLKEEIDIRL
CCCCCCHHHHHHHCH		64.53-
73UbiquitinationLSRVQDIKYEPQLLA
HHHHHCCCCCCEEEC		52.4221906983
73 (in isoform 1)Ubiquitination-52.4221906983
73SumoylationLSRVQDIKYEPQLLA
HHHHHCCCCCCEEEC		52.42-
73SumoylationLSRVQDIKYEPQLLA
HHHHHCCCCCCEEEC		52.42-
73 (in isoform 3)Ubiquitination-52.4221906983
73 (in isoform 5)Ubiquitination-52.4221906983
99 (in isoform 4)Ubiquitination-25.3521906983
105UbiquitinationYNYLYRMKALDAIRT
HHHHHHHHHHHHHHH		36.48-
117 (in isoform 2)Ubiquitination-14.0521906983
130UbiquitinationHPRSLMGKNFRSYLL
CCHHHCCCCHHHHHH		38.66-
133 (in isoform 5)Ubiquitination-33.5121906983
139 (in isoform 4)Ubiquitination-4.6021906983
147UbiquitinationRNTSTPFKGVRKALI
CCCCCCCHHHHHHHH		58.67-
151 (in isoform 1)Ubiquitination-45.1721906983
151UbiquitinationTPFKGVRKALIDTLL
CCCHHHHHHHHHHHH		45.1721906983
151 (in isoform 3)Ubiquitination-45.1721906983
157 (in isoform 2)Ubiquitination-3.4921906983
163PhosphorylationTLLDGYETARYGTGV
HHHCHHHHHHHCCCC		14.14-
166PhosphorylationDGYETARYGTGVFGQ
CHHHHHHHCCCCCCH		19.3016094384
173 (in isoform 5)Ubiquitination-28.2821906983
176PhosphorylationGVFGQNEYLRYQEAL
CCCCHHHHHHHHHHH		12.2025884760
179PhosphorylationGQNEYLRYQEALSEL
CHHHHHHHHHHHHHH		14.22-
191UbiquitinationSELATAVKARIGSSQ
HHHHHHHHHHHCCCH		29.502190698
191 (in isoform 1)Ubiquitination-29.5021906983
195 (in isoform 2)Ubiquitination-18.72-
206UbiquitinationRHHQSAAKDLTQSPE
HHHHHHHHHHHCCCC		53.65-
209PhosphorylationQSAAKDLTQSPEVSP
HHHHHHHHCCCCCCC		36.8122199227
211PhosphorylationAAKDLTQSPEVSPTT
HHHHHHCCCCCCCCE		20.1422199227
215PhosphorylationLTQSPEVSPTTIQVT
HHCCCCCCCCEEEEE		18.1826657352
217PhosphorylationQSPEVSPTTIQVTYL
CCCCCCCCEEEEEEC		29.0822199227
218PhosphorylationSPEVSPTTIQVTYLP
CCCCCCCEEEEEECC		16.8827732954
222PhosphorylationSPTTIQVTYLPSSQK
CCCEEEEEECCCCCC		11.7227732954
223PhosphorylationPTTIQVTYLPSSQKS
CCEEEEEECCCCCCC		20.1227732954
226PhosphorylationIQVTYLPSSQKSKRA
EEEEECCCCCCCHHH		42.6922199227
227PhosphorylationQVTYLPSSQKSKRAK
EEEECCCCCCCHHHH		39.4225627689
229UbiquitinationTYLPSSQKSKRAKHF
EECCCCCCCHHHHHH		60.95-
234UbiquitinationSQKSKRAKHFLELKS
CCCCHHHHHHHHCHH		38.63-
241PhosphorylationKHFLELKSFKDNYNT
HHHHHCHHHHHHHHH		50.5923312004
243UbiquitinationFLELKSFKDNYNTLE
HHHCHHHHHHHHHHH		52.75-
246PhosphorylationLKSFKDNYNTLESTL
CHHHHHHHHHHHHCC		21.4728796482
248PhosphorylationSFKDNYNTLESTL--
HHHHHHHHHHHCC--		22.88-
251PhosphorylationDNYNTLESTL-----
HHHHHHHHCC-----		37.8129214152
252PhosphorylationNYNTLESTL------
HHHHHHHCC------		27.4128450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CA043_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CA043_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CA043_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPM2_HUMANTPM2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CA043_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-166, AND MASSSPECTROMETRY.

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