dbPTM

ABCA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ABCA3_HUMAN
UniProt AC	Q99758
Protein Name	ATP-binding cassette sub-family A member 3
Gene Name	ABCA3
Organism	Homo sapiens (Human).
Sequence Length	1704
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol..
Protein Sequence	MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQPPTAEEGR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	N-linked_Glycosylation	LALLLWKNYTLQKRK HHHHHHHCCCHHHHH	24.36	-
19	Ubiquitination	WKNYTLQKRKVLVTV HHCCCHHHHHHHHHH	58.25	-
53	N-linked_Glycosylation	IQSENVPNATIYPGQ CCCCCCCCCEECCCC	45.49	-
124	N-linked_Glycosylation	EDYIRYDNCSSSVLA HHHHCCCCCCCHHHH	20.73	24142515
140	N-linked_Glycosylation	VVFEHPFNHSKEPLP HHEECCCCCCCCCCC	42.87	24142515
152	Phosphorylation	PLPLAVKYHLRFSYT CCCCEEEEEEEEEEC	10.25	68703609
197	Phosphorylation	NPGPREPTSPDGGEP CCCCCCCCCCCCCCC	48.41	46156447
239	Phosphorylation	RQLFQRLTVTIKRFP HHHHHHHHHEECCCC	20.14	46156453
241	Phosphorylation	LFQRLTVTIKRFPYP HHHHHHHEECCCCCC	18.62	46156459
385	Phosphorylation	GGFLYFFTYIPYFFV CHHHHHHHCCCHHHC	15.61	46156465
503	Ubiquitination	KPRAVAGKEEEDSDP CCCHHCCCCCCCCCH	52.82	-
508	Phosphorylation	AGKEEEDSDPEKALR CCCCCCCCCHHHHHH	59.34	27251275
512	Ubiquitination	EEDSDPEKALRNEYF CCCCCHHHHHHHHHC	59.10	-
518	Phosphorylation	EKALRNEYFEAEPED HHHHHHHHCCCCHHH	15.40	108417627
531	Ubiquitination	EDLVAGIKIKHLSKV HHHHHCEEEEEHHHE	44.80	-
575	Phosphorylation	NGAGKTTTLSMLTGL CCCCCCCHHHHHHCC	23.28	46156471
586	Phosphorylation	LTGLFPPTSGRAYIS HHCCCCCCCCCEEEC	44.01	46156477
620	N-linked_Glycosylation	QHDILFDNLTVAEHL CCCCCCCCCCHHHHH	30.22	-
646	Ubiquitination	QKCPEEVKQMLHIIG CCCHHHHHHHHHHHC	33.02	-
783	N-linked_Glycosylation	LVHHHVPNATLESSA HHHHCCCCCEEECCC	44.46	-
845	Phosphorylation	RVGKLVDSSMDIQAI HHHCCCCCCCCCCEE	21.78	27732954
846	Phosphorylation	VGKLVDSSMDIQAIQ HHCCCCCCCCCCEEE	18.93	27732954
866	Phosphorylation	YQHERRASDWAVDSN HHHHHHHCCCCCCCC	31.69	68714185
872	Phosphorylation	ASDWAVDSNLCGAMD HCCCCCCCCCCCCCC	25.71	28102081
1082	Phosphorylation	SNFPQPRSALQAAKD ECCCCCHHHHHHHHH	39.76	29449344
1088	Ubiquitination	RSALQAAKDQFNEGR HHHHHHHHHHHHHCC	55.89	-
1214	Phosphorylation	ATAYTRLTIFNILSG HHHHHHHHHHHHHHH	21.89	46156435
1220	Phosphorylation	LTIFNILSGIATFLM HHHHHHHHHHHHHHH	25.10	46156429
1229	Phosphorylation	IATFLMVTIMRIPAV HHHHHHHHHHHCCCC	8.62	46156441
1265	Phosphorylation	GMAVSSFYENYETRR HHHHHHHHHHHHCCC	12.76	18083107
1268	Phosphorylation	VSSFYENYETRRYCT HHHHHHHHHCCCCCC	13.51	18083107
1344	Phosphorylation	CALRRRRTLTELYTR HHHHHCCCHHHHHHH	35.90	20873877
1346	Phosphorylation	LRRRRTLTELYTRMP HHHCCCHHHHHHHCC	24.27	20873877
1349	Phosphorylation	RRTLTELYTRMPVLP CCCHHHHHHHCCCCC	6.00	20873877
1350	Phosphorylation	RTLTELYTRMPVLPE CCHHHHHHHCCCCCC	32.87	20873877
1372	Phosphorylation	RTRILAPSPDSLLHT CCEEECCCCHHHCCH	35.41	24076635
1384	Ubiquitination	LHTPLIIKELSKVYE CCHHHHHHHHHHHHH	45.68	21890473
1384	Ubiquitination	LHTPLIIKELSKVYE CCHHHHHHHHHHHHH	45.68	21890473
1387	Phosphorylation	PLIIKELSKVYEQRV HHHHHHHHHHHHHCC	22.59	68742619
1388	Ubiquitination	LIIKELSKVYEQRVP HHHHHHHHHHHHCCC	62.55	-
1514	Phosphorylation	HANKLVRTYSGGNKR CHHCEEEECCCCCCC	17.98	50558435
1515	Phosphorylation	ANKLVRTYSGGNKRK HHCEEEECCCCCCCE	8.51	50558439
1516	Phosphorylation	NKLVRTYSGGNKRKL HCEEEECCCCCCCEE	39.34	50558443
1607	Phosphorylation	HLKSKFGSGYSLRAK HHHHHCCCCCCHHHH	37.38	27732954
1609	Phosphorylation	KSKFGSGYSLRAKVQ HHHCCCCCCHHHHHC	13.26	27732954
1610	Phosphorylation	SKFGSGYSLRAKVQS HHCCCCCCHHHHHCC	18.20	24719451
1668	Ubiquitination	KVFGILEKAKEKYGV HHHHHHHHHHHHHCC	62.40	21890473
1668	Ubiquitination	KVFGILEKAKEKYGV HHHHHHHHHHHHHCC	62.40	21890473
1672	Ubiquitination	ILEKAKEKYGVDDYS HHHHHHHHHCCCCCC	46.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ABCA3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
124	N	Glycosylation	24142515
N-linked glycosylation at Asn-124 and Asn-140 is required for stability and efficient anterograde trafficking and prevents from proteasomal degradation.
140	N	Glycosylation	24142515
N-linked glycosylation at Asn-124 and Asn-140 is required for stability and efficient anterograde trafficking and prevents from proteasomal degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ABCA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ABCA3_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00217	Pulmonary surfactant metabolism dysfunction (SMDP)
OMIM Disease
610921	Pulmonary surfactant metabolism dysfunction 3 (SMDP3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00619	Imatinib

Regulatory Network of ABCA3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1265 AND TYR-1268, ANDMASS SPECTROMETRY.	18083107 [Abstract]

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