ABHD3_HUMAN - dbPTM
ABHD3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABHD3_HUMAN
UniProt AC Q8WU67
Protein Name Phospholipase ABHD3 {ECO:0000305}
Gene Name ABHD3 {ECO:0000312|HGNC:HGNC:18718}
Organism Homo sapiens (Human).
Sequence Length 409
Subcellular Localization Membrane
Single-pass type II membrane protein .
Protein Description Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids..
Protein Sequence MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
55UbiquitinationYLSSIAKKPQLVTGG
HHHHHHCCCEEECCC
29.0421890473
100 (in isoform 2)Phosphorylation-30.9522210691
102UbiquitinationLRPFITSKPPVQYRN
ECCHHCCCCCCEECC
44.6921906983
106 (in isoform 2)Phosphorylation-36.9222210691
156PhosphorylationTGTSKESYILHMIHL
CCCCHHHHHHHHHHH
14.4825884760
169PhosphorylationHLSEELGYRCVVFNN
HHHHHHCCEEEEECC
17.2925884760
288UbiquitinationKHRHMFVKQVDMDHV
HCCCEEEEECCHHHH
33.0821890473
297UbiquitinationVDMDHVMKAKSIREF
CCHHHHHHHHHHHHH
52.12-
299UbiquitinationMDHVMKAKSIREFDK
HHHHHHHHHHHHHHH
40.68-
328PhosphorylationYYTDASPSPRLKSVG
HCCCCCCCCCHHCCC
21.8417081983
332UbiquitinationASPSPRLKSVGIPVL
CCCCCCHHCCCCCEE
44.362190698
395UbiquitinationTYMDRVFKQFVQAMV
HHHHHHHHHHHHHHH
39.71-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABHD3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABHD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABHD3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABHD3_HUMAN !!

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABHD3_HUMAN

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Related Literatures of Post-Translational Modification

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