| UniProt ID | ABHD3_HUMAN | |
|---|---|---|
| UniProt AC | Q8WU67 | |
| Protein Name | Phospholipase ABHD3 {ECO:0000305} | |
| Gene Name | ABHD3 {ECO:0000312|HGNC:HGNC:18718} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 409 | |
| Subcellular Localization |
Membrane Single-pass type II membrane protein . |
|
| Protein Description | Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.. | |
| Protein Sequence | MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Ubiquitination | YLSSIAKKPQLVTGG HHHHHHCCCEEECCC | 29.04 | 21890473 | |
| 100 (in isoform 2) | Phosphorylation | - | 30.95 | 22210691 | |
| 102 | Ubiquitination | LRPFITSKPPVQYRN ECCHHCCCCCCEECC | 44.69 | 21906983 | |
| 106 (in isoform 2) | Phosphorylation | - | 36.92 | 22210691 | |
| 156 | Phosphorylation | TGTSKESYILHMIHL CCCCHHHHHHHHHHH | 14.48 | 25884760 | |
| 169 | Phosphorylation | HLSEELGYRCVVFNN HHHHHHCCEEEEECC | 17.29 | 25884760 | |
| 288 | Ubiquitination | KHRHMFVKQVDMDHV HCCCEEEEECCHHHH | 33.08 | 21890473 | |
| 297 | Ubiquitination | VDMDHVMKAKSIREF CCHHHHHHHHHHHHH | 52.12 | - | |
| 299 | Ubiquitination | MDHVMKAKSIREFDK HHHHHHHHHHHHHHH | 40.68 | - | |
| 328 | Phosphorylation | YYTDASPSPRLKSVG HCCCCCCCCCHHCCC | 21.84 | 17081983 | |
| 332 | Ubiquitination | ASPSPRLKSVGIPVL CCCCCCHHCCCCCEE | 44.36 | 2190698 | |
| 395 | Ubiquitination | TYMDRVFKQFVQAMV HHHHHHHHHHHHHHH | 39.71 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ABHD3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABHD3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABHD3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ABHD3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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