ECEL1_HUMAN - dbPTM
ECEL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ECEL1_HUMAN
UniProt AC O95672
Protein Name Endothelin-converting enzyme-like 1
Gene Name ECEL1
Organism Homo sapiens (Human).
Sequence Length 775
Subcellular Localization Membrane
Single-pass type II membrane protein.
Protein Description May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides..
Protein Sequence MEPPYSLTAHYDEFQEVKYVSRCGAGGARGASLPPGFPLGAARSATGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationPYSLTAHYDEFQEVK
CCCEEECCCCCCCCE		18.0725072903
32PhosphorylationAGGARGASLPPGFPL
CCCCCCCCCCCCCCC		44.2122210691
239PhosphorylationLYKAQGVYSAAALFS
HHHHHCHHHHHHHHE		10.2222817900
246PhosphorylationYSAAALFSLTVSLDD
HHHHHHHEEEEEECC		24.7922617229
248PhosphorylationAAALFSLTVSLDDRN
HHHHHEEEEEECCCC		13.5722617229
250PhosphorylationALFSLTVSLDDRNSS
HHHEEEEEECCCCCC		22.3522617229
255N-linked_GlycosylationTVSLDDRNSSRYVIR
EEEECCCCCCEEEEE		51.86UniProtKB CARBOHYD
259PhosphorylationDDRNSSRYVIRIDQD
CCCCCCEEEEEECCC		11.3722817900
269PhosphorylationRIDQDGLTLPERTLY
EECCCCCCCCCCEEE		45.8822985185
299PhosphorylationVFMERVLSLLGADAV
HHHHHHHHHHCHHHH		20.7729507054
322N-linked_GlycosylationQVEQQLANITVSEHD
HHHHHHHCCCCCCCH		38.77UniProtKB CARBOHYD
336PhosphorylationDDLRRDVSSMYNKVT
HHHHHHHHHHHCCCH		17.4230622161
337PhosphorylationDLRRDVSSMYNKVTL
HHHHHHHHHHCCCHH		25.7430622161
339PhosphorylationRRDVSSMYNKVTLGQ
HHHHHHHHCCCHHHH		17.4930622161
343PhosphorylationSSMYNKVTLGQLQKI
HHHHCCCHHHHHHHH		27.1230622161
400PhosphorylationPHRVLHNYLVWRVVV
CHHHHHHHHHHHHHH		7.59-
433UbiquitinationQEMEGSDKPQELARV
HHHCCCCCHHHHHHH		50.74-
478UbiquitinationQQLVEDIKYILGQRL
HHHHHHHHHHHHHCH		38.26-
505PhosphorylationAARAKLQYMMVMVGY
HHHHHHHHHHHHHCC		9.5226074081
512PhosphorylationYMMVMVGYPDFLLKP
HHHHHHCCCCCCCCC		6.5526074081
542PhosphorylationYFKNILNSIRFSIQL
HHHHHHHHHHHHHEE		16.2224719451
546PhosphorylationILNSIRFSIQLSVKK
HHHHHHHHHEECHHH		10.2827251275
550PhosphorylationIRFSIQLSVKKIRQE
HHHHHEECHHHHHHH		18.6027251275
573PhosphorylationPPQALNAYYLPNKNQ
CHHHHHCEECCCCCC		12.40-
656N-linked_GlycosylationCIVRLYDNFTVYNQR
HEEEECCCEEEEECE		22.41UniProtKB CARBOHYD
667AcetylationYNQRVNGKHTLGENI
EECEECCCCCCCCCC		28.3618527123
681AcetylationIADMGGLKLAYHAYQ
CHHHHHHHHHHHHHH		34.0518527131
727PhosphorylationCIKRRSQSIYLQVLT
HHHCCCCEEEEEHHH		17.91-
734PhosphorylationSIYLQVLTDKHAPEH
EEEEEHHHCCCCHHH		44.11-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ECEL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ECEL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ECEL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ECEL1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615065Arthrogryposis, distal, 5D (DA5D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ECEL1_HUMAN

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Related Literatures of Post-Translational Modification

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