HMR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMR1_HUMAN
• UniProt AC: Q95460
• Protein Name: Major histocompatibility complex class I-related gene protein
• Gene Name: MR1
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Subcellular Localization: Cell membrane; Single-pass membrane protein; Extracellular side. Endoplasmic reticulum.; Isoform 4: Secreted.; Isoform 3: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane . The larger proportion remains in the ER i
• Protein Description: Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent..
• Protein Sequence: MGELMAFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQESETIPLVMKAVSGSIVLVIVLAGVGVLVWRRRPREQNGAIYLPTPDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	VKHSDSRTHSLRYFR CCCCCCCCCEEEEEE	21.55	-
107	N-linked_Glycosylation	KRLQRHYNHSGSHTY HHHHHHHCCCCCHHH	19.40	12794138
195	Ubiquitination	KRFLEYGKDTLQRTE HHHHHHCHHHHHCCC	46.79	-
338	Phosphorylation	NGAIYLPTPDR---- CCCEECCCCCC----	34.91	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENV_HV1H2	env	physical	10708443
GAG_HV1H2	gag	physical	10708443
FATE1_HUMAN	FATE1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Biochemical features of the MHC-related protein 1 consistent with animmunological function.";
Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H.,Hansen T.H., Lybarger L.;
J. Immunol. 170:6090-6098(2003).
Cited for: FUNCTION, SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE SITE,GLYCOSYLATION AT ASN-107, INTERACTION WITH B2M; TAPBP; CALR AND PDIA3,AND MUTAGENESIS OF CYS-283.
PubMed: 12794138