dbPTM

GAG_HV1H2 - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GAG_HV1H2
UniProt AC	P04591
Protein Name	Gag polyprotein
Gene Name	gag
Organism	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1).
Sequence Length	500
Subcellular Localization	Gag polyprotein: Host cell membrane Lipid-anchor. Host endosome, host multivesicular body . These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartment
Protein Description	Gag polyprotein: Mediates, with Gag-Pol polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).; Matrix protein p17: Targets the polyprotein to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus (By similarity). Matrix protein is part of the pre-integration complex. Implicated in the release from host cell mediated by Vpu. Binds to RNA (By similarity).; Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry. [PubMed: 12660176 Host restriction factors such as monkey TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species]
Protein Sequence	MGARASVLSGGELDRWEKIRLRPGGKKKYKLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALDKIEEEQNKSKKKAQQAAADTGHSNQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKIVKCFNCGKEGHTARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPEESFRSGVETTTPPQKQEPIDKELYPLTSLRSLFGNDPSSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGARASVLS ------CCCCEECCC	24.62	-
148	Phosphorylation	QMVHQAISPRTLNAW CCCCCCCCHHHHHHH	16.02	-
387	Methylation	RGNFRNQRKIVKCFN CCCCCCCCCEEEEEC	33.93	-
409	Methylation	ARNCRAPRKKGCWKC CCCCCCCCCCCCCCC	52.94	-
475	Sumoylation	ETTTPPQKQEPIDKE CCCCCCCCCCCCCHH	63.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
148	S	Phosphorylation	Kinase	MAPK1	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GAG_HV1H2 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GAG_HV1H2 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EED_HUMAN	EED	physical	9880543
CD81_HUMAN	CD81	physical	16533950
CD63_HUMAN	CD63	physical	16533950
PPIA_HUMAN	PPIA	physical	12767222
TS101_HUMAN	TSG101	physical	12767222
ACTB_HUMAN	ACTB	physical	16101678
ACTG_HUMAN	ACTG1	physical	16101678
TS101_HUMAN	TSG101	physical	16434471
UBS3A_HUMAN	UBASH3A	physical	18006034
ABCE1_HUMAN	ABCE1	physical	18006034
NEDD4_HUMAN	NEDD4	physical	20164219
UBC_HUMAN	UBC	physical	9525617
ACTS_HUMAN	ACTA1	physical	9841925
VIF_HV1B1	vif	physical	11172097
VIF_HV1BR	vif	physical	11172097
VIF_HV1H2	vif	physical	11172097
UBC_HUMAN	UBC	physical	11112487
UBC_HUMAN	UBC	physical	11087859
TS101_HUMAN	TSG101	physical	21070952
TS101_HUMAN	TSG101	physical	14581525
NEDD4_HUMAN	NEDD4	physical	14581525
GAG_HV1H2	gag	physical	14722278
TS101_HUMAN	TSG101	physical	14722278
TS101_HUMAN	TSG101	physical	14581576
PDC6I_HUMAN	PDCD6IP	physical	14505569
TS101_HUMAN	TSG101	physical	11427703
PDC6I_HUMAN	PDCD6IP	physical	20929444
JUN_HUMAN	JUN	physical	17538020
DHX9_HUMAN	DHX9	physical	16527808
TS101_HUMAN	TSG101	physical	18439901
IF2B1_HUMAN	IGF2BP1	physical	18385235
TS101_HUMAN	TSG101	physical	17182674
PDC6I_HUMAN	PDCD6IP	physical	18032513
NEF_HV1H2	nef	physical	15137387
FMR1_HUMAN	FMR1	physical	19249802
TS101_HUMAN	TSG101	physical	21304933
UBC9_HUMAN	UBE2I	physical	15613319
SUMO1_HUMAN	SUMO1	physical	15613319
DAXX_HUMAN	DAXX	physical	15613319
HERC5_HUMAN	HERC5	physical	22093708
PDC6I_HUMAN	PDCD6IP	physical	17350572
TNIP1_HUMAN	TNIP1	physical	11090181
SOCS1_HUMAN	SOCS1	physical	18172216
TRIM5_MACMU	TRIM5	physical	20956011
TRIM5_HUMAN	TRIM5	physical	21455494
TRIM5_MACMU	TRIM5	physical	21455494
TR150_HUMAN	THRAP3	physical	22190034
SPCS_HUMAN	SEPSECS	physical	22190034
NS1BP_HUMAN	IVNS1ABP	physical	22190034
DDX49_HUMAN	DDX49	physical	22190034
ANM1_HUMAN	PRMT1	physical	22190034
OLA1_HUMAN	OLA1	physical	22190034
E2AK2_HUMAN	EIF2AK2	physical	22190034
SPF45_HUMAN	RBM17	physical	22190034
SYEP_HUMAN	EPRS	physical	22190034
MCA3_HUMAN	EEF1E1	physical	22190034
SYDC_HUMAN	DARS	physical	22190034
SYRC_HUMAN	RARS	physical	22190034
AIMP1_HUMAN	AIMP1	physical	22190034
SYHM_HUMAN	HARS2	physical	22190034
SYMC_HUMAN	MARS	physical	22190034
SYK_HUMAN	KARS	physical	22190034
SYLC_HUMAN	LARS	physical	22190034
SYQ_HUMAN	QARS	physical	22190034
SYTC_HUMAN	TARS	physical	22190034
SYIC_HUMAN	IARS	physical	22190034
SYNM_HUMAN	NARS2	physical	22190034
AIMP2_HUMAN	AIMP2	physical	22190034
SDCB1_HUMAN	SDCBP	physical	22190034
NOLC1_HUMAN	NOLC1	physical	22190034
SDCG8_HUMAN	SDCCAG8	physical	22190034
RINI_HUMAN	RNH1	physical	22190034
THUM1_HUMAN	THUMPD1	physical	22190034
LRC47_HUMAN	LRRC47	physical	22190034
CSDE1_HUMAN	CSDE1	physical	22190034
STRAP_HUMAN	STRAP	physical	22190034
MYPT1_HUMAN	PPP1R12A	physical	22190034
CTNA3_HUMAN	CTNNA3	physical	22190034
YTHD3_HUMAN	YTHDF3	physical	22190034
NOL12_HUMAN	NOL12	physical	22190034
NH2L1_HUMAN	NHP2L1	physical	22190034
RM11_HUMAN	MRPL11	physical	22190034
TS101_HUMAN	TSG101	physical	23895345
PDC6I_HUMAN	PDCD6IP	physical	23895345
MB12B_HUMAN	MVB12B	physical	23895345
VP37B_HUMAN	VPS37B	physical	23895345
VPS28_HUMAN	VPS28	physical	23895345
RN115_HUMAN	RNF115	physical	24852021
PPIA_HUMAN	PPIA	physical	23448277
LRSM1_HUMAN	LRSAM1	physical	15256501
SNUT1_HUMAN	SART1	physical	26362536
LYRIC_HUMAN	MTDH	physical	26362536
NAT10_HUMAN	NAT10	physical	26362536
RS16_HUMAN	RPS16	physical	26362536
MPP9_HUMAN	MPHOSPH9	physical	26362536
IF16_HUMAN	IFI16	physical	26362536
INT2_HUMAN	INTS2	physical	26362536
H1T_HUMAN	HIST1H1T	physical	26362536
RS6_HUMAN	RPS6	physical	26362536
TCOF_HUMAN	TCOF1	physical	26362536
HTAI2_HUMAN	HTATIP2	physical	26362536
RL37A_HUMAN	RPL37A	physical	26362536
RL27A_HUMAN	RPL27A	physical	26362536
RL11_HUMAN	RPL11	physical	26362536
RL36A_HUMAN	RPL36A	physical	26362536
SON_HUMAN	SON	physical	26362536
RS2_HUMAN	RPS2	physical	26362536
RS3_HUMAN	RPS3	physical	26362536
RL34_HUMAN	RPL34	physical	26362536
GUC2A_HUMAN	GUCA2A	physical	26362536
RSBN1_HUMAN	RSBN1	physical	26362536
DDX5_HUMAN	DDX5	physical	26362536
RL28_HUMAN	RPL28	physical	26362536
MCCA_HUMAN	MCCC1	physical	26362536
ACACB_HUMAN	ACACB	physical	26362536
CHD3_HUMAN	CHD3	physical	26362536
ACTB_HUMAN	ACTB	physical	26362536
ACACA_HUMAN	ACACA	physical	26362536
RSBNL_HUMAN	RSBN1L	physical	26362536
DDX17_HUMAN	DDX17	physical	26362536
IF2P_HUMAN	EIF5B	physical	26362536
LIPA1_HUMAN	PPFIA1	physical	26362536
FRG1_HUMAN	FRG1	physical	26362536
SRRM2_HUMAN	SRRM2	physical	26362536
RS5_HUMAN	RPS5	physical	26362536
RL35_HUMAN	RPL35	physical	26362536
RL29_HUMAN	RPL29	physical	26362536
AHNK_HUMAN	AHNAK	physical	25631074
AT1A1_HUMAN	ATP1A1	physical	25631074
ATX2L_HUMAN	ATXN2L	physical	25631074
TCPQ_HUMAN	CCT8	physical	25631074
CD2AP_HUMAN	CD2AP	physical	25631074
CDV3_HUMAN	CDV3	physical	25631074
CSDE1_HUMAN	CSDE1	physical	25631074
SRC8_HUMAN	CTTN	physical	25631074
DDX3X_HUMAN	DDX3X	physical	25631074
DSG2_HUMAN	DSG2	physical	25631074
EF1A1_HUMAN	EEF1A1	physical	25631074
IF4B_HUMAN	EIF4B	physical	25631074
IF4G1_HUMAN	EIF4G1	physical	25631074
IF5_HUMAN	EIF5	physical	25631074
41_HUMAN	EPB41	physical	25631074
E41L2_HUMAN	EPB41L2	physical	25631074
E41L3_HUMAN	EPB41L3	physical	25631074
SYEP_HUMAN	EPRS	physical	25631074
FAS_HUMAN	FASN	physical	25631074
FLNA_HUMAN	FLNA	physical	25631074
FLNB_HUMAN	FLNB	physical	25631074
GEMI5_HUMAN	GEMIN5	physical	25631074
GGYF2_HUMAN	GIGYF2	physical	25631074
VIGLN_HUMAN	HDLBP	physical	25631074
H12_HUMAN	HIST1H1C	physical	25631074
HNRPM_HUMAN	HNRNPM	physical	25631074
HORN_HUMAN	HRNR	physical	25631074
IRS4_HUMAN	IRS4	physical	25631074
LARP1_HUMAN	LARP1	physical	25631074
MAP4_HUMAN	MAP4	physical	25631074
KI67_HUMAN	MKI67	physical	25631074
AFAD_HUMAN	MLLT4	physical	25631074
LYRIC_HUMAN	MTDH	physical	25631074
NUFP2_HUMAN	NUFIP2	physical	25631074
HAP28_HUMAN	PDAP1	physical	25631074
PKP1_HUMAN	PKP1	physical	25631074
PRKDC_HUMAN	PRKDC	physical	25631074
PRC2A_HUMAN	PRRC2A	physical	25631074
PRC2C_HUMAN	PRRC2C	physical	25631074
SEMG1_HUMAN	SEMG1	physical	25631074
SEMG2_HUMAN	SEMG2	physical	25631074
PAIRB_HUMAN	SERBP1	physical	25631074
AAAT_HUMAN	SLC1A5	physical	25631074
4F2_HUMAN	SLC3A2	physical	25631074
LAP2A_HUMAN	TMPO	physical	25631074
LAP2B_HUMAN	TMPO	physical	25631074
TOX4_HUMAN	TOX4	physical	25631074
TPR_HUMAN	TPR	physical	25631074
RL40_HUMAN	UBA52	physical	25631074
UBAP2_HUMAN	UBAP2	physical	25631074
UBP2L_HUMAN	UBAP2L	physical	25631074
XRN1_HUMAN	XRN1	physical	25631074
ZCCHV_HUMAN	ZC3HAV1	physical	25631074
RBM26_HUMAN	RBM26	physical	25631074
GAG_HV1H2	gag	physical	25631074
POL_HV1H2	gag-pol	physical	25631074
TLR2_HUMAN	TLR2	physical	26347747
TLR1_HUMAN	TLR1	physical	26347747
CTRO_HUMAN	CIT	physical	27339686
TS101_HUMAN	TSG101	physical	27648839

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GAG_HV1H2

Related Literatures of Post-Translational Modification