dbPTM

CTRO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CTRO_HUMAN
UniProt AC	O14578
Protein Name	Citron Rho-interacting kinase
Gene Name	CIT
Organism	Homo sapiens (Human).
Sequence Length	2027
Subcellular Localization	Cytoplasm.
Protein Description	Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2..
Protein Sequence	MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLKFKYGA -------CCCCCCCC	40.73	22814378
13 (in isoform 3)	Phosphorylation	-	44.18	25849741
39	Phosphorylation	QGKPPFMTQQQMSPL CCCCCCCCHHHCCCC	24.49	29523821
44	Phosphorylation	FMTQQQMSPLSREGI CCCHHHCCCCCHHHH	20.53	24719451
47	Phosphorylation	QQQMSPLSREGILDA HHHCCCCCHHHHHHH	31.50	29523821
71	Ubiquitination	QPALMKIKHVSNFVR CCHHHHHHHHHHHHH	32.22	29967540
71 (in isoform 4)	Ubiquitination	-	32.22	-
79	Ubiquitination	HVSNFVRKYSDTIAE HHHHHHHHHHHHHHH	43.75	29967540
81	Phosphorylation	SNFVRKYSDTIAELQ HHHHHHHHHHHHHHH	31.17	28348404
83	Phosphorylation	FVRKYSDTIAELQEL HHHHHHHHHHHHHHH	19.02	28348404
95	Ubiquitination	QELQPSAKDFEVRSL HHHCCCCCCCCHHHH	68.25	21906983
95 (in isoform 1)	Ubiquitination	-	68.25	21906983
95 (in isoform 2)	Ubiquitination	-	68.25	21906983
117	Acetylation	EVQVVREKATGDIYA EEEEEEHHCCCCCHH	40.46	7695767
126	Ubiquitination	TGDIYAMKVMKKKAL CCCCHHHHHHHHHHH	30.88	-
126 (in isoform 4)	Ubiquitination	-	30.88	-
140	Phosphorylation	LLAQEQVSFFEEERN HHHHHHHHHHHHHHC	24.74	30266825
223	Ubiquitination	GYVHRDIKPENILVD HHHCCCCCHHHEEEC	51.04	24816145
232	Phosphorylation	ENILVDRTGHIKLVD HHEEECCCCCEEEEE	28.75	-
236	Ubiquitination	VDRTGHIKLVDFGSA ECCCCCEEEEECCCC	36.46	-
236 (in isoform 4)	Ubiquitination	-	36.46	-
245	Ubiquitination	VDFGSAAKMNSNKMV EECCCCCCCCCCCCC	38.03	29967540
245 (in isoform 4)	Ubiquitination	-	38.03	-
250	Ubiquitination	AAKMNSNKMVNAKLP CCCCCCCCCCCCCCC	44.01	29967540
307	Phosphorylation	RSPFAEGTSARTFNN CCCCCCCCCCHHHHH	15.66	19691289
308	Phosphorylation	SPFAEGTSARTFNNI CCCCCCCCCHHHHHH	26.98	19691289
323	Ubiquitination	MNFQRFLKFPDDPKV HCHHHHCCCCCCCCC	52.73	-
323 (in isoform 4)	Ubiquitination	-	52.73	-
350	Ubiquitination	CGQKERLKFEGLCCH CCCHHHCCCCCEECC	47.82	29967540
350 (in isoform 4)	Ubiquitination	-	47.82	-
362	Acetylation	CCHPFFSKIDWNNIR ECCCCCCCCCHHHCC	39.26	129615
371	Phosphorylation	DWNNIRNSPPPFVPT CHHHCCCCCCCCCCC	29.00	25159151
380	Ubiquitination	PPFVPTLKSDDDTSN CCCCCCCCCCCCCCC	55.08	2190698
380 (in isoform 1)	Ubiquitination	-	55.08	21906983
380 (in isoform 2)	Ubiquitination	-	55.08	21906983
398	Phosphorylation	PEKNSWVSSSPCQLS CCCCCCCCCCCCCCC	20.88	25627689
400	Phosphorylation	KNSWVSSSPCQLSPS CCCCCCCCCCCCCCC	23.37	22210691
403	Ubiquitination	WVSSSPCQLSPSGFS CCCCCCCCCCCCCCC	48.65	21890473
407	Ubiquitination	SPCQLSPSGFSGEEL CCCCCCCCCCCCCCC	49.44	21890473
431	Phosphorylation	ALGILGRSESVVSGL HHCCCCCCHHHHCCC	32.21	25159151
433	Phosphorylation	GILGRSESVVSGLDS CCCCCCHHHHCCCCC	29.12	25159151
436	Phosphorylation	GRSESVVSGLDSPAK CCCHHHHCCCCCCCC	31.33	30266825
440	Phosphorylation	SVVSGLDSPAKTSSM HHHCCCCCCCCCCHH	31.62	19664994
444	Phosphorylation	GLDSPAKTSSMEKKL CCCCCCCCCHHHHHH	28.30	26074081
445	Phosphorylation	LDSPAKTSSMEKKLL CCCCCCCCHHHHHHH	27.29	24114839
445	Ubiquitination	LDSPAKTSSMEKKLL CCCCCCCCHHHHHHH	27.29	21890473
446	Phosphorylation	DSPAKTSSMEKKLLI CCCCCCCHHHHHHHH	35.87	28122231
449	Ubiquitination	AKTSSMEKKLLIKSK CCCCHHHHHHHHHCH	39.83	21890473
465	Ubiquitination	LQDSQDKCHKMEQEM HHCCHHHHHHHHHHH	5.12	21890473
467	Ubiquitination	DSQDKCHKMEQEMTR CCHHHHHHHHHHHHH	54.31	29967540
469	Ubiquitination	QDKCHKMEQEMTRLH HHHHHHHHHHHHHHH	48.47	21890473
473	Phosphorylation	HKMEQEMTRLHRRVS HHHHHHHHHHHHHHH	29.35	20068231
480	Phosphorylation	TRLHRRVSEVEAVLS HHHHHHHHHHHHHHC	33.83	30266825
487	Phosphorylation	SEVEAVLSQKEVELK HHHHHHHCHHHHHHC	32.38	23927012
489	Ubiquitination	VEAVLSQKEVELKAS HHHHHCHHHHHHCCC	61.42	29967540
518	Ubiquitination	ITECSSLKRSLEQAR HHHHHHHHHHHHHHH	41.72	32015554
518	Acetylation	ITECSSLKRSLEQAR HHHHHHHHHHHHHHH	41.72	26051181
529	Phosphorylation	EQARMEVSQEDDKAL HHHHHHCCHHHHHHH	17.97	24719451
553	Ubiquitination	SRKLQEIKEQEYQAQ HHHHHHHHHHHHHHH	53.22	29967540
582	Phosphorylation	LVSARRRSDLYESEL HHHHHHHHHHHHHHH	30.10	30266825
585	Phosphorylation	ARRRSDLYESELRES HHHHHHHHHHHHHHH	23.54	23927012
587	Phosphorylation	RRSDLYESELRESRL HHHHHHHHHHHHHHH	28.51	23186163
600	Ubiquitination	RLAAEEFKRKATECQ HHHHHHHHHHHHHHH	57.16	29967540
652	Phosphorylation	LEKAVKASTEATELL HHHHHHHHHHHHHHH	22.51	18452278
653	Phosphorylation	EKAVKASTEATELLQ HHHHHHHHHHHHHHH	34.20	18452278
656	Phosphorylation	VKASTEATELLQNIR HHHHHHHHHHHHHHH	22.42	18452278
699 (in isoform 4)	Phosphorylation	-	38.29	30266825
709 (in isoform 4)	Phosphorylation	-	24.55	-
741	Phosphorylation	KDLADKETLENMMQR HHHCCHHHHHHHHHH	45.15	20363803
772	Phosphorylation	AMINAMDSKIRSLEQ HHHHHHHHHHHHHHH	19.52	24043423
776	Phosphorylation	AMDSKIRSLEQRIVE HHHHHHHHHHHHHHH	39.47	25599653
794	Phosphorylation	ANKLAANSSLFTQRN HHHHHHCCCHHHHHH	24.56	28857561
795	Phosphorylation	NKLAANSSLFTQRNM HHHHHCCCHHHHHHH	27.58	23312004
810	Phosphorylation	KAQEEMISELRQQKF HHHHHHHHHHHHHHH	29.30	24719451
825	Ubiquitination	YLETQAGKLEAQNRK HHHHHHHHHHHHHHH	46.28	29967540
841	Phosphorylation	EEQLEKISHQDHSDK HHHHHHHCCCCCCCH	26.60	22673903
846	Phosphorylation	KISHQDHSDKNRLLE HHCCCCCCCHHHHHH	59.58	22673903
848	2-Hydroxyisobutyrylation	SHQDHSDKNRLLELE CCCCCCCHHHHHHHH	47.16	-
867	Ubiquitination	EVSLEHEEQKLELKR HHCCHHHHHHHHHHH	55.73	29967540
869	Ubiquitination	SLEHEEQKLELKRQL CCHHHHHHHHHHHHH	47.40	21890473
873	Ubiquitination	EEQKLELKRQLTELQ HHHHHHHHHHHHHHH	28.82	21890473
882	Phosphorylation	QLTELQLSLQERESQ HHHHHHHHHHHHHHH	18.29	19413330
911	Ubiquitination	LRQAKTELEETTAEA HHHHHHHHHHHHHHH	9.73	21890473
915	Ubiquitination	KTELEETTAEAEEEI HHHHHHHHHHHHHHH	26.27	21890473
969	Phosphorylation	ELNNQNFYLSKQLDE HHHHCCEEHHHHHHH	20.02	-
999	Phosphorylation	DHLRREITEREMQLT HHHHHHHHHHHHHHH	25.00	26437602
1054	Ubiquitination	RSVLGDEKSQFECRV HHHHCCHHHHHHHHH	55.06	30230243
1072	Ubiquitination	QRMLDTEKQSRARAD HHHHCHHHHHHHHHH	56.52	30230243
1085	Phosphorylation	ADQRITESRQVVELA HHHHHHHHHHHHHHH	21.25	25599653
1096	Ubiquitination	VELAVKEHKAEILAL HHHHHHHHHHHHHHH	28.98	30230243
1108	Ubiquitination	LALQQALKEQKLKAE HHHHHHHHHHCHHHH	62.20	32015554
1111	Ubiquitination	QQALKEQKLKAESLS HHHHHHHCHHHHHHH	53.71	30230243
1114	Ubiquitination	LKEQKLKAESLSDKL HHHHCHHHHHHHHHH	23.26	30230243
1137	Phosphorylation	MLEMNARSLQQKLET HHHHHHHHHHHHHHH	28.28	22673903
1141	Ubiquitination	NARSLQQKLETEREL HHHHHHHHHHHHHHH	35.02	29967540
1150	Ubiquitination	ETERELKQRLLEEQA HHHHHHHHHHHHHHH	54.61	32015554
1153	Ubiquitination	RELKQRLLEEQAKLQ HHHHHHHHHHHHHHH	8.09	30230243
1158	Ubiquitination	RLLEEQAKLQQQMDL HHHHHHHHHHHHHHH	46.66	29967540
1167	Ubiquitination	QQQMDLQKNHIFRLT HHHHHHHHHHHHHHH	58.76	29967540
1183	Ubiquitination	GLQEALDRADLLKTE HHHHHHHHHHHHHHH	30.74	29967540
1196	Phosphorylation	TERSDLEYQLENIQV HHHHHHHHHHHHHEE	26.20	-
1200	Ubiquitination	DLEYQLENIQVLYSH HHHHHHHHHEEEEEC	38.29	29967540
1209	Ubiquitination	QVLYSHEKVKMEGTI EEEEECCCCCCEEEC	41.55	29967540
1229	Ubiquitination	LIDFLQAKMDQPAKK HHHHHHHHCCCCHHH	30.01	29967540
1242	Phosphorylation	KKKKGLFSRRKEDPA HHCCCCCCCCCCCCC	35.90	28674151
1251	Ubiquitination	RKEDPALPTQVPLQY CCCCCCCCCCCCCCH	23.92	29967540
1262	Ubiquitination	PLQYNELKLALEKEK CCCHHHHHHHHHHHH	26.07	29967540
1271	Ubiquitination	ALEKEKARCAELEEA HHHHHHHHHHHHHHH	31.11	29967540
1282	Phosphorylation	LEEALQKTRIELRSA HHHHHHHHHHHHHHH	24.74	30622161
1304	Ubiquitination	KATDHPHPSTPATAR HCCCCCCCCCCHHHH	44.33	29967540
1305	Phosphorylation	ATDHPHPSTPATARQ CCCCCCCCCCHHHHH	43.94	25159151
1306	Phosphorylation	TDHPHPSTPATARQQ CCCCCCCCCHHHHHH	22.76	27422710
1309	Phosphorylation	PHPSTPATARQQIAM CCCCCCHHHHHHHHH	24.47	27732954
1317	Phosphorylation	ARQQIAMSAIVRSPE HHHHHHHHHHHCCCC	13.06	28464451
1322	Phosphorylation	AMSAIVRSPEHQPSA HHHHHHCCCCCCCCH	24.60	23401153
1328	Phosphorylation	RSPEHQPSAMSLLAP CCCCCCCCHHHHCCC	29.99	30266825
1331	Phosphorylation	EHQPSAMSLLAPPSS CCCCCHHHHCCCCCC	21.68	20873877
1343	Phosphorylation	PSSRRKESSTPEEFS CCCCCCCCCCHHHHH	42.41	19691289
1344	Phosphorylation	SSRRKESSTPEEFSR CCCCCCCCCHHHHHH	49.42	19691289
1345	Phosphorylation	SRRKESSTPEEFSRR CCCCCCCCHHHHHHH	43.96	19691289
1350	Phosphorylation	SSTPEEFSRRLKERM CCCHHHHHHHHHHHH	21.55	19691289
1382	Phosphorylation	KCAVCLDTVHFGRQA CEEEEECHHHCCCHH	11.70	-
1410	Phosphorylation	CSTCLPATCGLPAEY CCCCCCCCCCCCHHH	12.74	-
1417	Phosphorylation	TCGLPAEYATHFTEA CCCCCHHHHHHHHHH	20.93	-
1419	Phosphorylation	GLPAEYATHFTEAFC CCCHHHHHHHHHHHH	19.34	-
1432	Phosphorylation	FCRDKMNSPGLQTKE HHHHHCCCCCCCCCC	19.49	25159151
1433 (in isoform 3)	Phosphorylation	-	42.37	21406692
1434 (in isoform 3)	Phosphorylation	-	30.18	21406692
1435 (in isoform 3)	Phosphorylation	-	7.11	21406692
1437	Phosphorylation	MNSPGLQTKEPSSSL CCCCCCCCCCCCCCC	42.28	24732914
1437 (in isoform 3)	Phosphorylation	-	42.28	25849741
1467	Phosphorylation	QQGWDRKYIVLEGSK CCCCCCEEEEEECCE	9.35	-
1473	Phosphorylation	KYIVLEGSKVLIYDN EEEEEECCEEEEECH	15.37	-
1571	Ubiquitination	GGRVSREKAEADAKL CCCCCHHHHHHHHHH	50.87	-
1582	Phosphorylation	DAKLLGNSLLKLEGD HHHHHCCCHHHCCCC	33.03	22199227
1613 (in isoform 4)	Ubiquitination	-	2.27	-
1720	Phosphorylation	LRYNENLSKYCIRKE EECCCCHHHHHHHHH	32.91	28102081
1721	Acetylation	RYNENLSKYCIRKEI ECCCCHHHHHHHHHC	47.51	19608861
1759	Phosphorylation	YEIDMKQYTLEEFLD EEEECHHHCHHHHHC	14.05	-
1760	Phosphorylation	EIDMKQYTLEEFLDK EEECHHHCHHHHHCC	25.79	-
1763	Acetylation	MKQYTLEEFLDKNDH CHHHCHHHHHCCCCC	55.40	19608861
1899	Acetylation	KLRVICCKGNLVKES CEEEEEECCCEECCC	46.55	25953088
1917	Phosphorylation	HHRGPSTSRSSPNKR CCCCCCCCCCCCCCC	34.21	28102081
1919	Phosphorylation	RGPSTSRSSPNKRGP CCCCCCCCCCCCCCC	50.33	26699800
1920	Phosphorylation	GPSTSRSSPNKRGPP CCCCCCCCCCCCCCC	31.23	25849741
1928	Phosphorylation	PNKRGPPTYNEHITK CCCCCCCCCCHHHHH	41.95	23312004
1929	Phosphorylation	NKRGPPTYNEHITKR CCCCCCCCCHHHHHH	25.07	25159151
1934	Phosphorylation	PTYNEHITKRVASSP CCCCHHHHHHHHCCC	18.08	-
1939	Phosphorylation	HITKRVASSPAPPEG HHHHHHHCCCCCCCC	33.72	30266825
1940	Phosphorylation	ITKRVASSPAPPEGP HHHHHHCCCCCCCCC	18.49	30266825
1948	Phosphorylation	PAPPEGPSHPREPST CCCCCCCCCCCCCCC	57.91	24732914
1954	Phosphorylation	PSHPREPSTPHRYRE CCCCCCCCCCCCCCC	50.22	24732914
1955	Phosphorylation	SHPREPSTPHRYREG CCCCCCCCCCCCCCC	33.55	28258704
1971	Phosphorylation	TELRRDKSPGRPLER CHHCCCCCCCCCCCC	36.55	29255136
1981	Phosphorylation	RPLEREKSPGRMLST CCCCCCCCCCCCCCC	28.03	27251275
1987	Phosphorylation	KSPGRMLSTRRERSP CCCCCCCCCCCCCCC	15.55	18691976
1988	Phosphorylation	SPGRMLSTRRERSPG CCCCCCCCCCCCCCC	29.77	27251275
1993	Phosphorylation	LSTRRERSPGRLFED CCCCCCCCCCCCCCC	27.27	23401153
2001	Phosphorylation	PGRLFEDSSRGRLPA CCCCCCCCCCCCCCC	18.10	23927012
2002	Phosphorylation	GRLFEDSSRGRLPAG CCCCCCCCCCCCCCC	51.59	23927012
2003	Methylation	RLFEDSSRGRLPAGA CCCCCCCCCCCCCCC	37.90	-
2013	Phosphorylation	LPAGAVRTPLSQVNK CCCCCCCCCHHHHCC	23.22	28985074
2016	Phosphorylation	GAVRTPLSQVNKVWD CCCCCCHHHHCCHHC	33.03	28857561
2025	Phosphorylation	VNKVWDQSSV----- HCCHHCCCCC-----	30.51	20044836
2026	Phosphorylation	NKVWDQSSV------ CCHHCCCCC------	26.64	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CTRO_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CTRO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CTRO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHOA_HUMAN	RHOA	physical	8543060
RHOB_HUMAN	RHOB	physical	8543060
RAC1_HUMAN	RAC1	physical	8543060
HGS_HUMAN	HGS	physical	21748597
ZN706_HUMAN	ZNF706	physical	22939629
UBP28_HUMAN	USP28	physical	22939629
GAG_HV1H2	gag	physical	27339686

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CTRO_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1721, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433 AND SER-440, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1971 AND SER-1993, ANDMASS SPECTROMETRY.	17081983 [Abstract]