UBS3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBS3A_HUMAN
• UniProt AC: P57075
• Protein Name: Ubiquitin-associated and SH3 domain-containing protein A
• Gene Name: UBASH3A
• Organism: Homo sapiens (Human).
• Sequence Length: 661
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain..
• Protein Sequence: MAAGETQLYAKVSNKLKSRSSPSLLEPLLAMGFPVHTALKALAATGRKTAEEALAWLHDHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESKRQCAKNRAHEVFPHVTLCDFFTCEDQKVECLYEALKRAGDRLLGSFPTAVPLALHSSISYLGFFVSGSPADVIREFAMTFATEASLLAGTSVSRFWIFSQVPGHGPNLRLSNLTRASFVSHYILQKYCSVKPCTKQLHLTLAHKFYPHHQRTLEQLARAIPLGHSCQWTAALYSRDMRFVHYQTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENYTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQALQATVARKSVLVVRHGERVDQIFGKAWLQQCSTPDGKYYRPDLNFPCSLPRRSRGIKDFENDPPLSSCGIFQSRIAGDALLDSGIRISSVFASPALRCVQTAKLILEELKLEKKIKIRVEPGIFEWTKWEAGKTTPTLMSLEELKEANFNIDTDYRPAFPLSALMPAESYQEYMDRCTASMVQIVNTCPQDTGVILIVSHGSTLDSCTRPLLGLPPRECGDFAQLVRKIPSLGMCFCEENKEEGKWELVNPPVKTLTHGANAAFNWRNWISGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAAGETQLYAKVS --CCCCHHHHHHHHH	23.98	26552605
9	Phosphorylation	AAGETQLYAKVSNKL CCCHHHHHHHHHHHC	8.44	26552605
11	Ubiquitination	GETQLYAKVSNKLKS CHHHHHHHHHHHCCC	32.41	22817900
13	Phosphorylation	TQLYAKVSNKLKSRS HHHHHHHHHHCCCCC	27.78	29083192
15	Ubiquitination	LYAKVSNKLKSRSSP HHHHHHHHCCCCCCH	50.19	16429130
17	Ubiquitination	AKVSNKLKSRSSPSL HHHHHHCCCCCCHHH	45.49	22817900
20	Phosphorylation	SNKLKSRSSPSLLEP HHHCCCCCCHHHHHH	54.41	27251275
21	Phosphorylation	NKLKSRSSPSLLEPL HHCCCCCCHHHHHHH	19.87	27251275
23	Phosphorylation	LKSRSSPSLLEPLLA CCCCCCHHHHHHHHH	47.75	27251275
48	Ubiquitination	ALAATGRKTAEEALA HHHHCCCCCHHHHHH	54.13	29967540
75	Ubiquitination	DPIPQEYALFLCPTG CCCCHHHHHHHCCCC	7.35	22817900
105	Ubiquitination	QCAKNRAHEVFPHVT HHHHHHHHHHCCCCE	28.63	22817900
123	Acetylation	FFTCEDQKVECLYEA EEECCHHHHHHHHHH	52.93	30592701
124	Ubiquitination	FTCEDQKVECLYEAL EECCHHHHHHHHHHH	5.37	22817900
141	Ubiquitination	AGDRLLGSFPTAVPL HHHHHHCCCCCHHHH	28.20	22505724
153	Ubiquitination	VPLALHSSISYLGFF HHHHHHCCCEEEEEC	12.57	22505724
173	Ubiquitination	ADVIREFAMTFATEA HHHHHHHHHHHHHHH	7.43	22505724
202	Ubiquitination	SQVPGHGPNLRLSNL ECCCCCCCCCCHHHH	30.89	22817900
212	Ubiquitination	RLSNLTRASFVSHYI CHHHHHHHHHHHHHH	11.33	22817900
213	Phosphorylation	LSNLTRASFVSHYIL HHHHHHHHHHHHHHH	23.92	-
221	Ubiquitination	FVSHYILQKYCSVKP HHHHHHHHHHHCCCC	25.72	22817900
240	Ubiquitination	LHLTLAHKFYPHHQR EHHHHHHHHCHHHHH	40.77	16429130
261	Ubiquitination	RAIPLGHSCQWTAAL HHCCCCCCHHHHHHH	13.25	22817900
261	Phosphorylation	RAIPLGHSCQWTAAL HHCCCCCCHHHHHHH	13.25	29978859
265	Phosphorylation	LGHSCQWTAALYSRD CCCCHHHHHHHHCCC	3.99	29978859
269	Phosphorylation	CQWTAALYSRDMRFV HHHHHHHHCCCCCHH	9.27	29978859
270	Phosphorylation	QWTAALYSRDMRFVH HHHHHHHCCCCCHHH	23.74	24719451
278	Ubiquitination	RDMRFVHYQTLRALF CCCCHHHHHHHHHHH	9.63	22505724
290	Ubiquitination	ALFQYKPQNVDELTL HHHCCCCCCCCEEEE	59.43	22505724
309	Ubiquitination	YIFVDPTQQDEASEG EEEECCCCCCCCCCC	54.86	22817900
310	Ubiquitination	IFVDPTQQDEASEGW EEECCCCCCCCCCCE	53.65	22505724
328	Ubiquitination	ISQRTGCRGFLPENY EECCCCCCCCCCCCC	40.00	22817900
347	Ubiquitination	SESDTWVKHRMYTFS CCCCCHHCCEEEEEE	19.63	16429130
352	O-linked_Glycosylation	WVKHRMYTFSLATDL HHCCEEEEEEEHHCC	9.45	30379171
358	Ubiquitination	YTFSLATDLNSRKDG EEEEEHHCCCCCCCC	37.94	22817900
368	Phosphorylation	SRKDGEASSRCSGEF CCCCCCCCCCCCCCC	17.64	23401153
369	Phosphorylation	RKDGEASSRCSGEFL CCCCCCCCCCCCCCH	44.33	30576142
372	Phosphorylation	GEASSRCSGEFLPQT CCCCCCCCCCCHHHH	40.00	23401153
375	Ubiquitination	SSRCSGEFLPQTARS CCCCCCCCHHHHHHH	16.02	22505724
377	Ubiquitination	RCSGEFLPQTARSLS CCCCCCHHHHHHHHH	34.49	22817900
379	Phosphorylation	SGEFLPQTARSLSSL CCCCHHHHHHHHHHH	23.30	29978859
382	Phosphorylation	FLPQTARSLSSLQAL CHHHHHHHHHHHHHH	30.09	28464451
384	Phosphorylation	PQTARSLSSLQALQA HHHHHHHHHHHHHHH	30.19	26657352
385	Phosphorylation	QTARSLSSLQALQAT HHHHHHHHHHHHHHH	29.78	29978859
387	Ubiquitination	ARSLSSLQALQATVA HHHHHHHHHHHHHHH	41.81	22505724
394	Ubiquitination	QALQATVARKSVLVV HHHHHHHHCCCEEEE	14.61	22505724
396	Ubiquitination	LQATVARKSVLVVRH HHHHHHCCCEEEEEC	34.87	16429130
406	Ubiquitination	LVVRHGERVDQIFGK EEEECCHHHHHHHHH	41.74	22505724
407	Ubiquitination	VVRHGERVDQIFGKA EEECCHHHHHHHHHH	5.74	22505724
413	Ubiquitination	RVDQIFGKAWLQQCS HHHHHHHHHHHHHCC	26.16	22505724
420	Phosphorylation	KAWLQQCSTPDGKYY HHHHHHCCCCCCCCC	38.34	-
421	Phosphorylation	AWLQQCSTPDGKYYR HHHHHCCCCCCCCCC	32.78	-
425	Ubiquitination	QCSTPDGKYYRPDLN HCCCCCCCCCCCCCC	46.63	22505724
426	Ubiquitination	CSTPDGKYYRPDLNF CCCCCCCCCCCCCCC	15.38	22505724
436	Phosphorylation	PDLNFPCSLPRRSRG CCCCCCCCCCCCCCC	41.46	28122231
441	Phosphorylation	PCSLPRRSRGIKDFE CCCCCCCCCCCCCCC	35.82	17081983
445	Ubiquitination	PRRSRGIKDFENDPP CCCCCCCCCCCCCCC	60.22	22505724
460	Ubiquitination	LSSCGIFQSRIAGDA CCCCCCCCCHHHHHH	29.85	29967540
463	Ubiquitination	CGIFQSRIAGDALLD CCCCCCHHHHHHHHH	6.43	30230243
477	Phosphorylation	DSGIRISSVFASPAL HCCCCHHHHHCCHHH	20.91	20166139
478	Ubiquitination	SGIRISSVFASPALR CCCCHHHHHCCHHHH	3.57	29967540
483	Ubiquitination	SSVFASPALRCVQTA HHHHCCHHHHHHHHH	12.73	29967540
491	Acetylation	LRCVQTAKLILEELK HHHHHHHHHHHHHHC	39.17	19820883
498	Ubiquitination	KLILEELKLEKKIKI HHHHHHHCCCCCCCE	58.86	29967540
501	Ubiquitination	LEELKLEKKIKIRVE HHHHCCCCCCCEEEC	70.95	30230243
501	Acetylation	LEELKLEKKIKIRVE HHHHCCCCCCCEEEC	70.95	19820889
502	Acetylation	EELKLEKKIKIRVEP HHHCCCCCCCEEECC	39.60	19820895
516	Ubiquitination	PGIFEWTKWEAGKTT CCCCEEECCCCCCCC	44.07	29967540
521	Ubiquitination	WTKWEAGKTTPTLMS EECCCCCCCCCCCCC	57.16	29967540
523	Phosphorylation	KWEAGKTTPTLMSLE CCCCCCCCCCCCCHH	20.12	22210691
541	Phosphorylation	EANFNIDTDYRPAFP HCCCCCCCCCCCCCC	31.00	22210691
564	Methylation	SYQEYMDRCTASMVQ HHHHHHHHHHHHHHH	11.80	115385971
591	Ubiquitination	LIVSHGSTLDSCTRP EEEECCCCCCCCCCC	38.89	29967540
629	Ubiquitination	MCFCEENKEEGKWEL EEEEECCCCCCCEEE	61.49	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBS3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBS3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBS3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2L3_HUMAN	UBE2L3	physical	17588522
DYN1_HUMAN	DNM1	physical	17382318
AIFM1_HUMAN	AIFM1	physical	17709377
CBL_HUMAN	CBL	physical	17709377
CBL_HUMAN	CBL	physical	15159412
EGFR_HUMAN	EGFR	physical	15159412
CBL_HUMAN	CBL	physical	15107835
ABCE1_HUMAN	ABCE1	physical	18006034
GAG_HV1H2	gag	physical	18006034
K1C40_HUMAN	KRT40	physical	25416956
UBS3A_HUMAN	UBASH3A	physical	15159412
DAZP2_HUMAN	DAZAP2	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.