DDX49_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX49_HUMAN
• UniProt AC: Q9Y6V7
• Protein Name: Probable ATP-dependent RNA helicase DDX49
• Gene Name: DDX49
• Organism: Homo sapiens (Human).
• Sequence Length: 483
• Protein Sequence: MAGFAELGLSSWLVEQCRQLGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFSIKKIRFLVMDEADRLLEQGCTDFTVDLEAILAAVPARRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVSTVEQLDQRYLLVPEKVKDAYLVHLIQRFQDEHEDWSIIIFTNTCKTCQILCMMLRKFSFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFSVEEAEVLQILTQVNVVRRECEIKLEAAHFDEKKEINKRKQLILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEETLKRQKAGRAGHKGRPPRTPSGSHSGPVPSQGLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	QCRQLGLKQPTPVQL HHHHCCCCCCCCCCC	53.05	-
47	Acetylation	RDCLGCAKTGSGKTA CCCCCCCCCCCCHHH	58.45	25953088
47	Ubiquitination	RDCLGCAKTGSGKTA CCCCCCCCCCCCHHH	58.45	29967540
77	Phosphorylation	GIFCLVLTPTRELAY CEEEEEECCCHHHHH	18.35	24719451
127	Phosphorylation	KPHVVIATPGRLADH CCCEEEECCCHHHHH	18.36	25106551
186	Phosphorylation	RRQTLLFSATLTDTL HHHEEEEEEEHHHHH	21.95	27050516
188	Phosphorylation	QTLLFSATLTDTLRE HEEEEEEEHHHHHHH	29.06	27050516
223	Phosphorylation	VEQLDQRYLLVPEKV HHHHHHHEECCCHHH	9.96	19605366
272	Phosphorylation	CMMLRKFSFPTVALH HHHHHHCCCHHHHHH	33.09	-
293	Acetylation	ERFAALAKFKSSIYR HHHHHHHHHHHHHHH	54.92	25953088
293	Ubiquitination	ERFAALAKFKSSIYR HHHHHHHHHHHHHHH	54.92	29967540
305	Phosphorylation	IYRILIATDVASRGL HHHHHHHHHHHHCCC	24.82	27174698
309	Phosphorylation	LIATDVASRGLDIPT HHHHHHHHCCCCCCC	27.08	27174698
310	Methylation	IATDVASRGLDIPTV HHHHHHHCCCCCCCE	39.70	-
316	Phosphorylation	SRGLDIPTVQVVINH HCCCCCCCEEEEEEC	24.73	27174698
321	Ubiquitination	IPTVQVVINHNTPGL CCCEEEEEECCCCCC	4.57	24816145
325	Phosphorylation	QVVINHNTPGLPKIY EEEEECCCCCCCEEE	15.93	24719451
330	Ubiquitination	HNTPGLPKIYIHRVG CCCCCCCEEEEEECC	53.86	24816145
339	Ubiquitination	YIHRVGRTARAGRQG EEEECCCCCCCCCCC	17.99	24816145
375	Phosphorylation	KKKLEEFSVEEAEVL HHHHHHCCHHHHHHH	31.72	-
386	Phosphorylation	AEVLQILTQVNVVRR HHHHHHHHHHHHHHH	31.91	-
414	Ubiquitination	KKEINKRKQLILEGK HHHHHHHHHHHHCCC	51.57	29967540
421	Acetylation	KQLILEGKDPDLEAK HHHHHCCCCCCHHHH	57.63	26051181
421	Ubiquitination	KQLILEGKDPDLEAK HHHHHCCCCCCHHHH	57.63	29967540
428	Ubiquitination	KDPDLEAKRKAELAK CCCCHHHHHHHHHHH	45.09	24816145
437	Ubiquitination	KAELAKIKQKNRRFK HHHHHHHHHHHHHHH	55.29	24816145
444	Methylation	KQKNRRFKEKVEETL HHHHHHHHHHHHHHH	55.61	-
446	Ubiquitination	KNRRFKEKVEETLKR HHHHHHHHHHHHHHH	56.38	24816145
467	Methylation	GHKGRPPRTPSGSHS CCCCCCCCCCCCCCC	63.05	-
468	Phosphorylation	HKGRPPRTPSGSHSG CCCCCCCCCCCCCCC	27.81	25159151
470	Phosphorylation	GRPPRTPSGSHSGPV CCCCCCCCCCCCCCC	52.92	29978859
472	Phosphorylation	PPRTPSGSHSGPVPS CCCCCCCCCCCCCCC	20.86	23312004
474	Phosphorylation	RTPSGSHSGPVPSQG CCCCCCCCCCCCCCC	46.63	23312004
479	Phosphorylation	SHSGPVPSQGLV--- CCCCCCCCCCCC---	36.79	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX49_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX49_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX49_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	16169070
PNO1_HUMAN	PNO1	physical	22939629
PSB2_HUMAN	PSMB2	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.