dbPTM

ACACB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACACB_HUMAN
UniProt AC	O00763
Protein Name	Acetyl-CoA carboxylase 2
Gene Name	ACACB
Organism	Homo sapiens (Human).
Sequence Length	2458
Subcellular Localization	Mitochondrion . Nucleus . Endomembrane system. May associate with membranes.
Protein Description	Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity)..
Protein Sequence	MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIKLKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFPSQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRVEHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSDELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVPILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEESVRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPKDILTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFKYLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSRAPYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAVKDFNREKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYAELRGGSWVVIDATINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVKQEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRSTIRENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSPAST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	DSKPITKSKSEANLI CCCCCCCCHHHCCCC	32.53	24972180
37	Phosphorylation	KPITKSKSEANLIPS CCCCCCHHHCCCCCC	49.37	28258704
44	Phosphorylation	SEANLIPSQEPFPAS HHCCCCCCCCCCCCC	39.93	21902226
70	Phosphorylation	EGHTLPKTPSQAEPA CCCCCCCCCCCCCCC	26.66	23312004
72	Phosphorylation	HTLPKTPSQAEPASH CCCCCCCCCCCCCCC	47.45	28258704
91	Phosphorylation	DAGRRRNSLPPSHQK CCCCCCCCCCHHHCC	40.20	29116813
95	Phosphorylation	RRNSLPPSHQKPPRN CCCCCCHHHCCCCCC	36.29	23312004
106	Phosphorylation	PPRNPLSSSDAAPSP CCCCCCCCCCCCCCH	39.66	24275569
107	Phosphorylation	PRNPLSSSDAAPSPE CCCCCCCCCCCCCHH	28.08	24275569
169	Phosphorylation	MTNFILGSFDDYSSD HHHHHHCCCCCCCCC	23.27	113299501
175	Phosphorylation	GSFDDYSSDEDSVAG CCCCCCCCCCCCCCC	38.50	-
192	Phosphorylation	RESTRKGSRASLGAL CCCCCCCCHHHHCCE	27.92	28258704
195	Phosphorylation	TRKGSRASLGALSLE CCCCCHHHHCCEEEE	26.65	28258704
200	Phosphorylation	RASLGALSLEAYLTT HHHHCCEEEEEEECC	24.51	28258704
204	Phosphorylation	GALSLEAYLTTGEAE CCEEEEEEECCCCCC	8.66	25072903
206	Phosphorylation	LSLEAYLTTGEAETR EEEEEEECCCCCCCC	21.78	24043423
207	Phosphorylation	SLEAYLTTGEAETRV EEEEEECCCCCCCCC	30.35	24043423
212	Phosphorylation	LTTGEAETRVPTMRP ECCCCCCCCCCCCCC	43.97	24043423
216	Phosphorylation	EAETRVPTMRPSMSG CCCCCCCCCCCCCCH	23.97	24043423
220	Phosphorylation	RVPTMRPSMSGLHLV CCCCCCCCCCHHCHH	18.40	24972180
222	Phosphorylation	PTMRPSMSGLHLVKR CCCCCCCCHHCHHCC	42.41	25072903
243	Phosphorylation	LDLHRDFTVASPAEF CCCCCCCCCCCHHHH	21.32	23186163
246	Phosphorylation	HRDFTVASPAEFVTR CCCCCCCCHHHHHHH	21.95	25850435
262	Ubiquitination	GGDRVIEKVLIANNG CCCHHEEEEEEECCC	31.08	29967540
274	Ubiquitination	NNGIAAVKCMRSIRR CCCCHHHHHHHHHHH	20.00	-
454	Acetylation	IGFPLMIKASEGGGG HCCCEEEEECCCCCC	31.71	20167786
469	Phosphorylation	KGIRKAESAEDFPIL CCCCCCCCCCCCCEE	41.64	24275569
663	Ubiquitination	ENPDEGFKPSSGTVQ CCCCCCCCCCCCCEE	55.64	21906983
663 (in isoform 2)	Ubiquitination	-	55.64	21906983
663 (in isoform 1)	Ubiquitination	-	55.64	21906983
663	Acetylation	ENPDEGFKPSSGTVQ CCCCCCCCCCCCCEE	55.64	25953088
722	Ubiquitination	SNMVVALKELSIRGD HHHHHHHHHHCCCCC	47.04	-
725	Phosphorylation	VVALKELSIRGDFRT HHHHHHHCCCCCHHH	16.01	24719451
753	Phosphorylation	FQNNDIDTGWLDYLI HCCCCCCCCHHHHHH	30.50	-
808	Phosphorylation	GQVLPADSLLNLVDV CCCCCHHHHHHCCCH	36.54	46157487
860	Phosphorylation	NDGGLLLSYNGNSYT CCCCEEEEECCCCCE	19.27	29083192
861	Phosphorylation	DGGLLLSYNGNSYTT CCCEEEEECCCCCEE	27.36	29083192
865	Phosphorylation	LLSYNGNSYTTYMKE EEEECCCCCEEEEEC	25.84	29083192
866	Phosphorylation	LSYNGNSYTTYMKEE EEECCCCCEEEEECC	13.70	30873031
867	Phosphorylation	SYNGNSYTTYMKEEV EECCCCCEEEEECCC	15.98	29083192
868	Phosphorylation	YNGNSYTTYMKEEVD ECCCCCEEEEECCCC	17.24	29083192
869	Phosphorylation	NGNSYTTYMKEEVDS CCCCCEEEEECCCCE	9.82	29083192
880	Phosphorylation	EVDSYRITIGNKTCV CCCEEEEEECCEEEE	17.52	28258704
895	Phosphorylation	FEKENDPTVLRSPSA EEECCCCCEEECCCC	34.73	69213021
929	Biotinylation	YAEMEVMKMIMTLNV CHHHHHHHHHHHCCH	30.37	18247344
929	N6-biotinyllysine	YAEMEVMKMIMTLNV CHHHHHHHHHHHCCH	30.37	-
933	Phosphorylation	EVMKMIMTLNVQERG HHHHHHHHCCHHHCC	12.31	24114839
1074	Phosphorylation	QYASNITSVLCQFPS HHHHCHHHHHCCCCH	14.86	22210691
1081	Phosphorylation	SVLCQFPSQQIATIL HHHCCCCHHHHHHHH	35.69	22210691
1094	Phosphorylation	ILDCHAATLQRKADR HHHHHHHHHHHHCCC	24.98	22210691
1137	Phosphorylation	VLDLLRRYLRVEHHF HHHHHHHHHHHHHHH	7.76	29083192
1149	Phosphorylation	HHFQQAHYDKCVINL HHHHHHHHHHHEEEH	21.80	29083192
1292	Phosphorylation	NKVVCMASLEVYVRR CEEEEEEEEEEEECC	9.74	29759185
1340	Phosphorylation	NRMTVPISITNPDLL CCEEEEEEECCHHHH	19.79	9474075
1342	Phosphorylation	MTVPISITNPDLLRH EEEEEEECCHHHHHH	33.63	20166139
1350	Phosphorylation	NPDLLRHSTELFMDS CHHHHHHHHHHHHCC	19.69	23312004
1351	Phosphorylation	PDLLRHSTELFMDSG HHHHHHHHHHHHCCC	30.49	23312004
1357	Phosphorylation	STELFMDSGFSPLCQ HHHHHHCCCCHHHHH	29.92	25072903
1360	Phosphorylation	LFMDSGFSPLCQRMG HHHCCCCHHHHHHHC	22.08	23312004
1405	Phosphorylation	LFSEARTSLYSEDDC CCCHHHHHCCCHHHH	21.54	22798277
1413	Ubiquitination	LYSEDDCKSLREEPI CCCHHHHHHHCCCCE	60.56	-
1414	Phosphorylation	YSEDDCKSLREEPIH CCHHHHHHHCCCCEE	38.70	23312004
1450	Acetylation	RTFVQSKKNILVDYG HHHHHCCCCEEHHCC	55.24	19820785
1456	Phosphorylation	KKNILVDYGLRRITF CCCEEHHCCHHHHHE	15.58	21253578
1462	Phosphorylation	DYGLRRITFLIAQEK HCCHHHHHEEEECCC	15.58	20068231
1473	Ubiquitination	AQEKEFPKFFTFRAR ECCCCCCCCEEEECC	59.43	-
1489	Phosphorylation	EFAEDRIYRHLEPAL HHHHHHHHHHHHHHH	7.90	7947665
1557	Phosphorylation	DLITKEASFEYLQNE HCCCHHHHHHHHHHH	21.50	20068231
1560	Phosphorylation	TKEASFEYLQNEGER CHHHHHHHHHHHHHH	16.16	20068231
1618	Phosphorylation	VRYMVMRYGSRLWKL HHHHHHHCCCCCEEE	11.01	23828894
1620	Phosphorylation	YMVMRYGSRLWKLRV HHHHHCCCCCEEEEE	18.44	23828894
1641	Phosphorylation	INIRQTTTGSAVPIR EEEEECCCCCCCEEE	32.31	15632253
1658	Phosphorylation	ITNESGYYLDISLYK EECCCCEEEEEEEEE	11.04	21720203
1664	Phosphorylation	YYLDISLYKEVTDSR EEEEEEEEEEECCCC	9.79	12308941
1694	Phosphorylation	QHGMLINTPYVTKDL CCCEEECCCCCCHHH	14.70	22210691
1696	Phosphorylation	GMLINTPYVTKDLLQ CEEECCCCCCHHHHH	20.79	24043423
1698	Phosphorylation	LINTPYVTKDLLQAK EECCCCCCHHHHHHH	17.01	22210691
1826	Phosphorylation	AEGIPKIYVAANSGA HCCCCEEEEEECCCC	7.08	21406692
1831	Phosphorylation	KIYVAANSGARIGMA EEEEEECCCCCCCCH	29.15	30278072
1877	Phosphorylation	TRISSLNSVHCKHIE CCCCCCCCEECEECC	20.66	23403867
1891	Phosphorylation	EEGGESRYMITDIIG CCCCCCCEEEEEEEC	11.36	30174305
2081	Phosphorylation	IMAPWAQTVVTGRAR HHHCCCCEEECCCHH	14.81	20068231
2084	Phosphorylation	PWAQTVVTGRARLGG CCCCEEECCCHHHCC	19.33	20068231
2161	Phosphorylation	FANWRGFSGGMKDMY EECCCCCCCCHHHHH	36.94	28258704
2268	Phosphorylation	QLGEPDLSDKDRKDL HHCCCCCCHHHHHCH	50.42	26270265
2324	Phosphorylation	LEWKTARTFLYWRLR HHHHHHHHHHHHHHH	18.61	28258704
2327	Phosphorylation	KTARTFLYWRLRRLL HHHHHHHHHHHHHHH	5.58	28258704
2347	Phosphorylation	KQEILQASGELSHVH HHHHHHHCCCCCHHH	21.60	46157481
2404	Phosphorylation	STIRENITYLKHDSV CHHHHHHEEECHHHH	34.09	23532336
2405	Phosphorylation	TIRENITYLKHDSVL HHHHHHEEECHHHHH	15.23	24719451
2410	Phosphorylation	ITYLKHDSVLKTIRG HEEECHHHHHHHHHH	29.12	24719451
2432	Phosphorylation	VAVDCVIYLSQHISP HHHHHEEEHHHCCCH	4.66	26434552
2438	Phosphorylation	IYLSQHISPAERAQV EEHHHCCCHHHHHHH	18.88	26434552
2451	Phosphorylation	QVVHLLSTMDSPAST HHHHHHHCCCCCCCC	25.60	21815630
2454	Phosphorylation	HLLSTMDSPAST--- HHHHCCCCCCCC---	16.14	27134283
2458	Phosphorylation	TMDSPAST------- CCCCCCCC-------	44.74	46157493

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
222	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot
222	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
222	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS
222	S	Phosphorylation	Kinase	AMPK_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	Q8NHY2	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	DET1	Q7L5Y6	PMID:16794074
-	K	Ubiquitination	E3 ubiquitin ligase	DET1#COP1	Q7L5Y6#Q8NHY2	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
222	S	Phosphorylation		12488245
Phosphorylation at Ser-222 by AMPK inactivates the enzyme.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACACB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ACACB_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00173	Adenine
DB00121	Biotin

Regulatory Network of ACACB_HUMAN

Related Literatures of Post-Translational Modification

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