dbPTM

LYRIC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LYRIC_HUMAN
UniProt AC	Q86UE4
Protein Name	Protein LYRIC
Gene Name	MTDH
Organism	Homo sapiens (Human).
Sequence Length	582
Subcellular Localization	Endoplasmic reticulum membrane Single-pass membrane protein. Nucleus membrane Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. In epithelial cells, recruited to tight junctions (TJ) dur
Protein Description	Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance..
Protein Sequence	MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	2-Hydroxyisobutyrylation	LDLGLEPKRYPGWVI CCCCCCCCCCCCEEE	56.01	-
84	Phosphorylation	GARKKRRSPPRKREE HHHHHCCCCCCHHHH	43.20	30576142
88	Ubiquitination	KRRSPPRKREEAAAV HCCCCCCHHHHHHCC	70.68	-
107	Ubiquitination	PDDLALLKNLRSEEQ HHHHHHHHHHCCHHH	55.58	21890473
111	Phosphorylation	ALLKNLRSEEQKKKN HHHHHHCCHHHHHHH	48.96	25159151
121	Ubiquitination	QKKKNRKKLSEKPKP HHHHHHHHHCCCCCC	54.75	-
125	Ubiquitination	NRKKLSEKPKPNGRT HHHHHCCCCCCCCCE	55.77	-
127	Ubiquitination	KKLSEKPKPNGRTVE HHHCCCCCCCCCEEE	63.28	-
132	Phosphorylation	KPKPNGRTVEVAEGE CCCCCCCEEEEEECC	23.55	28176443
143	Phosphorylation	AEGEAVRTPQSVTAK EECCEEECCCCCCCC	21.05	29255136
146	Phosphorylation	EAVRTPQSVTAKQPP CEEECCCCCCCCCCC	23.73	30266825
148	Phosphorylation	VRTPQSVTAKQPPEI EECCCCCCCCCCCCC	33.12	28176443
150	Ubiquitination	TPQSVTAKQPPEIDK CCCCCCCCCCCCCCC	54.71	21890473
170	Acetylation	KKNKKKSKSDAKAVQ HHCHHCCHHHHHHHH	62.32	7676495
171	Phosphorylation	KNKKKSKSDAKAVQN HCHHCCHHHHHHHHH	50.30	24425749
174	2-Hydroxyisobutyrylation	KKSKSDAKAVQNSSR HCCHHHHHHHHHHCC	54.82	-
174	Acetylation	KKSKSDAKAVQNSSR HCCHHHHHHHHHHCC	54.82	7676507
174	Ubiquitination	KKSKSDAKAVQNSSR HCCHHHHHHHHHHCC	54.82	21890473
179	Phosphorylation	DAKAVQNSSRHDGKE HHHHHHHHCCCCCCC	16.20	28450419
180	Phosphorylation	AKAVQNSSRHDGKEV HHHHHHHCCCCCCCC	40.98	23927012
185	Acetylation	NSSRHDGKEVDEGAW HHCCCCCCCCCCCHH	61.70	26051181
185	Ubiquitination	NSSRHDGKEVDEGAW HHCCCCCCCCCCCHH	61.70	21890473
194	Phosphorylation	VDEGAWETKISHREK CCCCHHHHHCCHHHH	23.99	23186163
195	2-Hydroxyisobutyrylation	DEGAWETKISHREKR CCCHHHHHCCHHHHH	30.60	-
195	Acetylation	DEGAWETKISHREKR CCCHHHHHCCHHHHH	30.60	27452117
195	Ubiquitination	DEGAWETKISHREKR CCCHHHHHCCHHHHH	30.60	-
197	Phosphorylation	GAWETKISHREKRQQ CHHHHHCCHHHHHHH	20.32	23401153
212	Phosphorylation	RKRDKVLTDSGSLDS HHHHHCCCCCCCCCC	30.98	23663014
214	Phosphorylation	RDKVLTDSGSLDSTI HHHCCCCCCCCCCCC	25.66	30278072
216	Phosphorylation	KVLTDSGSLDSTIPG HCCCCCCCCCCCCCC	32.71	30278072
219	Phosphorylation	TDSGSLDSTIPGIEN CCCCCCCCCCCCCCC	33.26	23663014
220	Phosphorylation	DSGSLDSTIPGIENT CCCCCCCCCCCCCCE	30.75	23663014
227	Phosphorylation	TIPGIENTITVTTEQ CCCCCCCEEEEEHHH	12.77	23663014
229	Phosphorylation	PGIENTITVTTEQLT CCCCCEEEEEHHHEE	15.12	23663014
231	Phosphorylation	IENTITVTTEQLTTA CCCEEEEEHHHEEEE	18.90	23663014
232	Phosphorylation	ENTITVTTEQLTTAS CCEEEEEHHHEEEEE	19.87	23663014
236	Phosphorylation	TVTTEQLTTASFPVG EEEHHHEEEEECCCC	21.73	23663014
237	Phosphorylation	VTTEQLTTASFPVGS EEHHHEEEEECCCCC	28.97	23663014
239	Phosphorylation	TEQLTTASFPVGSKK HHHEEEEECCCCCCC	28.17	26434776
244	Phosphorylation	TASFPVGSKKNKGDS EEECCCCCCCCCCCC	40.46	26434776
246	Malonylation	SFPVGSKKNKGDSHL ECCCCCCCCCCCCCE	66.64	30639696
248	Malonylation	PVGSKKNKGDSHLNV CCCCCCCCCCCCEEE	73.33	26320211
248	Ubiquitination	PVGSKKNKGDSHLNV CCCCCCCCCCCCEEE	73.33	-
251	Phosphorylation	SKKNKGDSHLNVQVS CCCCCCCCCEEEEEE	38.24	25159151
258	Phosphorylation	SHLNVQVSNFKSGKG CCEEEEEEECCCCCC	21.32	25159151
261	Methylation	NVQVSNFKSGKGDST EEEEEECCCCCCCCE	63.65	-
262	Phosphorylation	VQVSNFKSGKGDSTL EEEEECCCCCCCCEE	41.41	27251275
264	Acetylation	VSNFKSGKGDSTLQV EEECCCCCCCCEEEE	67.64	-
264	Methylation	VSNFKSGKGDSTLQV EEECCCCCCCCEEEE	67.64	115972663
267	Phosphorylation	FKSGKGDSTLQVSSG CCCCCCCCEEEEECC	39.42	27251275
268	Phosphorylation	KSGKGDSTLQVSSGL CCCCCCCEEEEECCC	26.42	27251275
272	Phosphorylation	GDSTLQVSSGLNENL CCCEEEEECCCCCCE	13.01	-
273	Phosphorylation	DSTLQVSSGLNENLT CCEEEEECCCCCCEE	48.74	-
280	Phosphorylation	SGLNENLTVNGGGWN CCCCCCEEEECCCCC	24.41	-
289	Ubiquitination	NGGGWNEKSVKLSSQ ECCCCCHHHEECCCC	58.29	-
292	Ubiquitination	GWNEKSVKLSSQISA CCCHHHEECCCCCCC	50.14	-
294	Phosphorylation	NEKSVKLSSQISAGE CHHHEECCCCCCCCH	17.93	29255136
295	Phosphorylation	EKSVKLSSQISAGEE HHHEECCCCCCCCHH	41.80	30266825
298	Phosphorylation	VKLSSQISAGEEKWN EECCCCCCCCHHHHC	23.68	29255136
303	Acetylation	QISAGEEKWNSVSPA CCCCCHHHHCCCCHH	47.58	26051181
303	Ubiquitination	QISAGEEKWNSVSPA CCCCCHHHHCCCCHH	47.58	-
306	Phosphorylation	AGEEKWNSVSPASAG CCHHHHCCCCHHHCC	23.90	30266825
308	Phosphorylation	EEKWNSVSPASAGKR HHHHCCCCHHHCCCC	17.99	19664994
311	Phosphorylation	WNSVSPASAGKRKTE HCCCCHHHCCCCCCC	40.72	22167270
314	2-Hydroxyisobutyrylation	VSPASAGKRKTEPSA CCHHHCCCCCCCCCC	50.90	-
314	Acetylation	VSPASAGKRKTEPSA CCHHHCCCCCCCCCC	50.90	25953088
314	Methylation	VSPASAGKRKTEPSA CCHHHCCCCCCCCCC	50.90	12430023
314	Ubiquitination	VSPASAGKRKTEPSA CCHHHCCCCCCCCCC	50.90	-
323	Phosphorylation	KTEPSAWSQDTGDAN CCCCCCCCCCCCCCC	20.21	25159151
326	Phosphorylation	PSAWSQDTGDANTNG CCCCCCCCCCCCCCC	29.35	23186163
331	Phosphorylation	QDTGDANTNGKDWGR CCCCCCCCCCCCCCC	47.25	30108239
334	Acetylation	GDANTNGKDWGRSWS CCCCCCCCCCCCCCC	52.99	26051181
334	Ubiquitination	GDANTNGKDWGRSWS CCCCCCCCCCCCCCC	52.99	-
338	Methylation	TNGKDWGRSWSDRSI CCCCCCCCCCCCCCC	30.60	115482437
339	Phosphorylation	NGKDWGRSWSDRSIF CCCCCCCCCCCCCCC	27.30	25159151
341	Phosphorylation	KDWGRSWSDRSIFSG CCCCCCCCCCCCCCC	25.13	23898821
344	Phosphorylation	GRSWSDRSIFSGIGS CCCCCCCCCCCCCCC	32.73	21082442
347	Phosphorylation	WSDRSIFSGIGSTAE CCCCCCCCCCCCCCC	28.03	28464451
351	Phosphorylation	SIFSGIGSTAEPVSQ CCCCCCCCCCCCCCC	23.64	28450419
352	Phosphorylation	IFSGIGSTAEPVSQS CCCCCCCCCCCCCCC	29.81	28464451
357	Phosphorylation	GSTAEPVSQSTTSDY CCCCCCCCCCCCCCC	29.18	26552605
359	Phosphorylation	TAEPVSQSTTSDYQW CCCCCCCCCCCCCCE	26.58	27251275
360	Phosphorylation	AEPVSQSTTSDYQWD CCCCCCCCCCCCCEE	23.76	27251275
361	Phosphorylation	EPVSQSTTSDYQWDV CCCCCCCCCCCCEEC	25.50	29978859
362	Phosphorylation	PVSQSTTSDYQWDVS CCCCCCCCCCCEECC	34.12	29978859
364	Phosphorylation	SQSTTSDYQWDVSRN CCCCCCCCCEECCCC	15.98	28796482
369	Phosphorylation	SDYQWDVSRNQPYID CCCCEECCCCCCCCC	24.04	29978859
411	Phosphorylation	WVDEERASLLKSQEP CCCHHHHHHHHCCCC	40.22	28258704
415	Phosphorylation	ERASLLKSQEPIPDD HHHHHHHCCCCCCCC	39.48	25159151
426	Phosphorylation	IPDDQKVSDDDKEKG CCCCCCCCCCCCCCC	42.21	29255136
439	Phosphorylation	KGEGALPTGKSKKKK CCCCCCCCCCCCHHH	59.08	24732914
441	Acetylation	EGALPTGKSKKKKKK CCCCCCCCCCHHHHH	62.67	30585989
451	Ubiquitination	KKKKKKKKQGEDNST HHHHHCCCCCCCCCC	72.86	-
457	Phosphorylation	KKQGEDNSTAQDTEE CCCCCCCCCHHCHHH	37.12	28355574
458	Phosphorylation	KQGEDNSTAQDTEEL CCCCCCCCHHCHHHH	34.29	29255136
462	Phosphorylation	DNSTAQDTEELEKEI CCCCHHCHHHHHHHH	21.19	30108239
477	Phosphorylation	REDLPVNTSKTRPKQ HHHCCCCCCCCCCCC	31.66	29255136
478	Phosphorylation	EDLPVNTSKTRPKQE HHCCCCCCCCCCCCH	27.16	29255136
479	Acetylation	DLPVNTSKTRPKQEK HCCCCCCCCCCCCHH	46.65	25953088
489	Phosphorylation	PKQEKAFSLKTISTS CCCHHCEECEEECCC	33.54	24719451
491	Acetylation	QEKAFSLKTISTSDP CHHCEECEEECCCCH	42.48	25953088
491	Methylation	QEKAFSLKTISTSDP CHHCEECEEECCCCH	42.48	24659541
491	Ubiquitination	QEKAFSLKTISTSDP CHHCEECEEECCCCH	42.48	21890473
492	Phosphorylation	EKAFSLKTISTSDPA HHCEECEEECCCCHH	26.00	30266825
494	Phosphorylation	AFSLKTISTSDPAEV CEECEEECCCCHHHH	27.39	23401153
495	Phosphorylation	FSLKTISTSDPAEVL EECEEECCCCHHHHE	33.04	30266825
496	O-linked_Glycosylation	SLKTISTSDPAEVLV ECEEECCCCHHHHEE	34.50	31373491
496	Phosphorylation	SLKTISTSDPAEVLV ECEEECCCCHHHHEE	34.50	30266825
506	Phosphorylation	AEVLVKNSQPIKTLP HHHEEECCCCCCCCC	31.45	29214152
510	Ubiquitination	VKNSQPIKTLPPATS EECCCCCCCCCCCCC	51.17	-
511	Phosphorylation	KNSQPIKTLPPATST ECCCCCCCCCCCCCC	45.26	28555341
516	O-linked_Glycosylation	IKTLPPATSTEPSVI CCCCCCCCCCCCEEE	41.79	31373491
517	Phosphorylation	KTLPPATSTEPSVIL CCCCCCCCCCCEEEE	32.64	22468782
518	Phosphorylation	TLPPATSTEPSVILS CCCCCCCCCCEEEEE	47.78	22468782
521	Phosphorylation	PATSTEPSVILSKSD CCCCCCCEEEEECCC	18.63	28555341
525	Phosphorylation	TEPSVILSKSDSDKS CCCEEEEECCCCCCC	20.99	28348404
527	Phosphorylation	PSVILSKSDSDKSSS CEEEEECCCCCCCCC	38.68	30266825
529	Phosphorylation	VILSKSDSDKSSSQV EEEECCCCCCCCCCC	54.77	26657352
532	Phosphorylation	SKSDSDKSSSQVPPI ECCCCCCCCCCCCCH	39.97	23663014
533	Phosphorylation	KSDSDKSSSQVPPIL CCCCCCCCCCCCCHH	30.45	23663014
534	Phosphorylation	SDSDKSSSQVPPILQ CCCCCCCCCCCCHHH	42.14	23663014
543	Phosphorylation	VPPILQETDKSKSNT CCCHHHHCCCCCCCC	35.45	23312004
546	Phosphorylation	ILQETDKSKSNTKQN HHHHCCCCCCCCCCC	44.09	21712546
548	Phosphorylation	QETDKSKSNTKQNSV HHCCCCCCCCCCCCC	57.74	21712546
550	Phosphorylation	TDKSKSNTKQNSVPP CCCCCCCCCCCCCCH	40.89	21712546
558	Phosphorylation	KQNSVPPSQTKSETS CCCCCCHHHCCCCCC	44.40	-
560	Phosphorylation	NSVPPSQTKSETSWE CCCCHHHCCCCCCCC	40.66	-
562	Phosphorylation	VPPSQTKSETSWESP CCHHHCCCCCCCCCH	49.87	23927012
564	Phosphorylation	PSQTKSETSWESPKQ HHHCCCCCCCCCHHH	46.35	23927012
565	Phosphorylation	SQTKSETSWESPKQI HHCCCCCCCCCHHHH	25.46	23927012
568	Phosphorylation	KSETSWESPKQIKKK CCCCCCCCHHHHHHH	31.01	22167270
570	Ubiquitination	ETSWESPKQIKKKKK CCCCCCHHHHHHHHH	74.14	-
582	Phosphorylation	KKKARRET------- HHHHHHCC-------	41.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LYRIC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LYRIC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LYRIC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT16_HUMAN	ZBTB16	physical	19648967
PLEC_HUMAN	PLEC	physical	22939629
CBP_HUMAN	CREBBP	physical	18316612
TOPRS_HUMAN	TOPORS	physical	24529480
CBP_HUMAN	CREBBP	physical	26141861
SND1_HUMAN	SND1	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
JUN_HUMAN	JUN	physical	27956703
EP300_HUMAN	EP300	physical	27956703

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LYRIC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-344 ANDSER-369, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-308 ANDSER-426, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-308;SER-311; SER-426; THR-458 AND SER-568, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426, ANDMASS SPECTROMETRY.	18088087 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111; SER-298; SER-308;SER-311; SER-415 AND SER-426, AND MASS SPECTROMETRY.	17081983 [Abstract]