SYIC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYIC_HUMAN
• UniProt AC: P41252
• Protein Name: Isoleucine--tRNA ligase, cytoplasmic
• Gene Name: IARS
• Organism: Homo sapiens (Human).
• Sequence Length: 1262
• Subcellular Localization: Cytoplasm . Cytoplasm, cytosol .
• Protein Description: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA..
• Protein Sequence: MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTADF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLQQVPEN -------CCCCCCCC	35.25	19413330
81	Dimethylation	QSGFHVDRRFGWDCH HCCCCCCCCCCCCCC	34.44	-
81	Methylation	QSGFHVDRRFGWDCH HCCCCCCCCCCCCCC	34.44	115372607
82	Dimethylation	SGFHVDRRFGWDCHG CCCCCCCCCCCCCCC	29.93	-
82	Methylation	SGFHVDRRFGWDCHG CCCCCCCCCCCCCCC	29.93	115372613
87	Glutathionylation	DRRFGWDCHGLPVEY CCCCCCCCCCCEEEE	1.90	22555962
98	Ubiquitination	PVEYEIDKTLGIRGP EEEEEECCCCCCCCH	51.84	-
110	Ubiquitination	RGPEDVAKMGITEYN CCHHHHHHHCCEECH	37.19	-
111	Sulfoxidation	GPEDVAKMGITEYNN CHHHHHHHCCEECHH	3.19	30846556
120	Glutathionylation	ITEYNNQCRAIVMRY CEECHHHHCEEEEHH	3.27	22555962
132	Acetylation	MRYSAEWKSTVSRLG EHHCHHHHHHHHHHC	27.96	26051181
132	Ubiquitination	MRYSAEWKSTVSRLG EHHCHHHHHHHHHHC	27.96	-
133	Phosphorylation	RYSAEWKSTVSRLGR HHCHHHHHHHHHHCC	34.80	20860994
134	Phosphorylation	YSAEWKSTVSRLGRW HCHHHHHHHHHHCCC	20.83	20860994
136	Phosphorylation	AEWKSTVSRLGRWID HHHHHHHHHHCCCCC	23.13	23312004
167	Phosphorylation	WWVFKQLYDKGLVYR HHHHHHHHHCCCEEC	17.08	-
169	2-Hydroxyisobutyrylation	VFKQLYDKGLVYRGV HHHHHHHCCCEECCE	40.36	-
169	Ubiquitination	VFKQLYDKGLVYRGV HHHHHHHCCCEECCE	40.36	-
173	Phosphorylation	LYDKGLVYRGVKVMP HHHCCCEECCEEEEE	13.49	-
177	Acetylation	GLVYRGVKVMPFSTA CCEECCEEEEECCCC	35.32	19827493
187	Phosphorylation	PFSTACNTPLSNFES ECCCCCCCCCCCCCC	26.03	25627689
259	Sulfoxidation	RGRLLILMEARLSAL CCHHHHHHHHHHHHH	2.76	21406390
264	Phosphorylation	ILMEARLSALYKLES HHHHHHHHHHHHCCC	15.63	20068231
268	Ubiquitination	ARLSALYKLESDYEI HHHHHHHHCCCCHHH	46.78	21906983
271	Phosphorylation	SALYKLESDYEILER HHHHHCCCCHHHHHH	56.80	28796482
273	Phosphorylation	LYKLESDYEILERFP HHHCCCCHHHHHHCC	17.72	28796482
285	Ubiquitination	RFPGAYLKGKKYRPL HCCCCCCCCCCEECH	56.88	-
295	Phosphorylation	KYRPLFDYFLKCKEN CEECHHHHHHEECCC	11.95	-
298	Ubiquitination	PLFDYFLKCKENGAF CHHHHHHEECCCCCE	33.10	-
333	Phosphorylation	PYFGAEDYRVCMDFN CCCCCCCEEEEEECC	9.10	-
337	Sulfoxidation	AEDYRVCMDFNIIRK CCCEEEEEECCEEEC	6.36	21406390
344	Ubiquitination	MDFNIIRKDSLPVCP EECCEEECCCCCCCC	41.06	-
346	Phosphorylation	FNIIRKDSLPVCPVD CCEEECCCCCCCCCC	37.29	25849741
355	Phosphorylation	PVCPVDASGCFTTEV CCCCCCCCCCEEEEE	31.47	23927012
359	Phosphorylation	VDASGCFTTEVTDFA CCCCCCEEEEEECCC	26.56	23927012
360	Phosphorylation	DASGCFTTEVTDFAG CCCCCEEEEEECCCC	14.27	23927012
363	Phosphorylation	GCFTTEVTDFAGQYV CCEEEEEECCCCHHC	21.11	23927012
371	Ubiquitination	DFAGQYVKDADKSII CCCCHHCCCCCHHHH	42.12	21906983
375	Acetylation	QYVKDADKSIIRTLK HHCCCCCHHHHHHHH	45.32	23236377
375	Ubiquitination	QYVKDADKSIIRTLK HHCCCCCHHHHHHHH	45.32	-
382	2-Hydroxyisobutyrylation	KSIIRTLKEQGRLLV HHHHHHHHHCCCEEE	47.59	-
382	Succinylation	KSIIRTLKEQGRLLV HHHHHHHHHCCCEEE	47.59	23954790
409	Nitration	RSDTPLIYKAVPSWF CCCCCCEECCCCHHH	10.69	-
409	Phosphorylation	RSDTPLIYKAVPSWF CCCCCCEECCCCHHH	10.69	23917254
410	Ubiquitination	SDTPLIYKAVPSWFV CCCCCEECCCCHHHH	35.59	21906983
414	Phosphorylation	LIYKAVPSWFVRVEN CEECCCCHHHHCHHH	26.92	22617229
433	Glutathionylation	LLRNNDLCYWVPELV HHHCCCHHCHHHHHH	2.54	22555962
434	Phosphorylation	LRNNDLCYWVPELVR HHCCCHHCHHHHHHH	19.42	-
450	Acetylation	KRFGNWLKDARDWTI HCCCCHHHHCCCCCC	40.74	25953088
450	Methylation	KRFGNWLKDARDWTI HCCCCHHHHCCCCCC	40.74	42353337
450	Ubiquitination	KRFGNWLKDARDWTI HCCCCHHHHCCCCCC	40.74	21906983
496	Phosphorylation	ELSGAKISDLHRESV HHHCCCCHHHHHHCC	33.15	20873877
502	Phosphorylation	ISDLHRESVDHLTIP CHHHHHHCCCCCCCC	32.57	20873877
507	Phosphorylation	RESVDHLTIPSRCGK HHCCCCCCCCCCCCC	27.67	20873877
510	Phosphorylation	VDHLTIPSRCGKGSL CCCCCCCCCCCCCHH	36.03	20873877
516	Phosphorylation	PSRCGKGSLHRISEV CCCCCCCHHHHHHHC	25.20	27251275
606	Malonylation	QKMSKRKKNYPDPVS CCCCCCCCCCCCHHH	66.79	26320211
606	Ubiquitination	QKMSKRKKNYPDPVS CCCCCCCCCCCCHHH	66.79	-
608	Phosphorylation	MSKRKKNYPDPVSII CCCCCCCCCCHHHHH	20.21	28152594
617	Acetylation	DPVSIIQKYGADALR CHHHHHHHHCCCHHH	34.93	27452117
617	Ubiquitination	DPVSIIQKYGADALR CHHHHHHHHCCCHHH	34.93	21906983
626	Phosphorylation	GADALRLYLINSPVV CCCHHHHHEECCCCC	10.09	21406692
630	Phosphorylation	LRLYLINSPVVRAEN HHHHEECCCCCCHHH	16.45	21406692
641	2-Hydroxyisobutyrylation	RAENLRFKEEGVRDV CHHHHCCCHHHHHHH	48.71	-
641	Acetylation	RAENLRFKEEGVRDV CHHHHCCCHHHHHHH	48.71	26051181
641	Ubiquitination	RAENLRFKEEGVRDV CHHHHCCCHHHHHHH	48.71	-
672	Acetylation	QNVLRLQKEEEIEFL HHHHHCCCHHHHHHH	72.23	26051181
672	Ubiquitination	QNVLRLQKEEEIEFL HHHHHCCCHHHHHHH	72.23	21906983
680	Phosphorylation	EEEIEFLYNENTVRE HHHHHHHCCCCCCCC	26.25	-
688	Phosphorylation	NENTVRESPNITDRW CCCCCCCCCCCCHHH	16.81	20068231
692	Phosphorylation	VRESPNITDRWILSF CCCCCCCCHHHHHHH	26.59	20068231
717	Phosphorylation	EMAAYRLYTVVPRLV HHHHHHHHHHHHHHH	6.62	28152594
718	Phosphorylation	MAAYRLYTVVPRLVK HHHHHHHHHHHHHHH	21.44	28152594
731	Phosphorylation	VKFVDILTNWYVRMN HHHHHHHHHHHHHHH	24.84	20068231
773	Phosphorylation	CRLMAPYTPFLTELM HHHHCCCCHHHHHHH	13.40	-
777	Phosphorylation	APYTPFLTELMYQNL CCCCHHHHHHHHCCC	27.70	-
798	Phosphorylation	VSVQDKDTLSIHYLM CCCCCCCCEEEEEEE	28.31	24719451
800	Phosphorylation	VQDKDTLSIHYLMLP CCCCCCEEEEEEECH	14.93	24719451
803	Phosphorylation	KDTLSIHYLMLPRVR CCCEEEEEEECHHHH	7.67	-
816	2-Hydroxyisobutyrylation	VREELIDKKTESAVS HHHHHHCCCCHHHHH	55.38	-
816	Ubiquitination	VREELIDKKTESAVS HHHHHHCCCCHHHHH	55.38	-
817	Ubiquitination	REELIDKKTESAVSQ HHHHHCCCCHHHHHH	54.50	-
820	Phosphorylation	LIDKKTESAVSQMQS HHCCCCHHHHHHHHH	38.92	20068231
823	Phosphorylation	KKTESAVSQMQSVIE CCCHHHHHHHHHHHH	21.46	20068231
825	Sulfoxidation	TESAVSQMQSVIELG CHHHHHHHHHHHHHH	2.21	28183972
827	Phosphorylation	SAVSQMQSVIELGRV HHHHHHHHHHHHHCH	21.51	-
840	Phosphorylation	RVIRDRKTIPIKYPL CHHCCCCCCCCCCCC	32.64	24719451
844	Acetylation	DRKTIPIKYPLKEIV CCCCCCCCCCCCEEE	35.15	19608861
844	Malonylation	DRKTIPIKYPLKEIV CCCCCCCCCCCCEEE	35.15	26320211
844	Ubiquitination	DRKTIPIKYPLKEIV CCCCCCCCCCCCEEE	35.15	19608861
845	Phosphorylation	RKTIPIKYPLKEIVV CCCCCCCCCCCEEEE	17.95	22461510
848	2-Hydroxyisobutyrylation	IPIKYPLKEIVVIHQ CCCCCCCCEEEEEEC	40.67	-
848	Ubiquitination	IPIKYPLKEIVVIHQ CCCCCCCCEEEEEEC	40.67	21906983
861	Acetylation	HQDPEALKDIKSLEK ECCHHHHHHHHHHHH	65.54	23236377
861	Malonylation	HQDPEALKDIKSLEK ECCHHHHHHHHHHHH	65.54	26320211
861	Ubiquitination	HQDPEALKDIKSLEK ECCHHHHHHHHHHHH	65.54	-
864	Acetylation	PEALKDIKSLEKYII HHHHHHHHHHHHHHH	60.15	27452117
864	Ubiquitination	PEALKDIKSLEKYII HHHHHHHHHHHHHHH	60.15	-
865	Phosphorylation	EALKDIKSLEKYIIE HHHHHHHHHHHHHHH	41.94	24719451
868	Acetylation	KDIKSLEKYIIEELN HHHHHHHHHHHHHHC	47.22	26051181
868	Ubiquitination	KDIKSLEKYIIEELN HHHHHHHHHHHHHHC	47.22	21906983
869	Phosphorylation	DIKSLEKYIIEELNV HHHHHHHHHHHHHCC	9.58	28152594
878	Ubiquitination	IEELNVRKVTLSTDK HHHHCCCEEEEECCC	34.98	-
880	Phosphorylation	ELNVRKVTLSTDKNK HHCCCEEEEECCCCC	20.30	21406692
882	Phosphorylation	NVRKVTLSTDKNKYG CCCEEEEECCCCCCE	25.79	21406692
883	Phosphorylation	VRKVTLSTDKNKYGI CCEEEEECCCCCCEE	54.85	21406692
885	2-Hydroxyisobutyrylation	KVTLSTDKNKYGIRL EEEEECCCCCCEEEE	56.26	-
885	Ubiquitination	KVTLSTDKNKYGIRL EEEEECCCCCCEEEE	56.26	-
887	Ubiquitination	TLSTDKNKYGIRLRA EEECCCCCCEEEEEE	51.06	-
888	Phosphorylation	LSTDKNKYGIRLRAE EECCCCCCEEEEEEC	27.46	-
899	Sulfoxidation	LRAEPDHMVLGKRLK EEECCCCEECHHHHH	3.29	21406390
903	Acetylation	PDHMVLGKRLKGAFK CCCEECHHHHHHHHH	50.85	25953088
903	Malonylation	PDHMVLGKRLKGAFK CCCEECHHHHHHHHH	50.85	26320211
903	Ubiquitination	PDHMVLGKRLKGAFK CCCEECHHHHHHHHH	50.85	-
910	Acetylation	KRLKGAFKAVMTSIK HHHHHHHHHHHHHHH	39.27	25953088
910	Malonylation	KRLKGAFKAVMTSIK HHHHHHHHHHHHHHH	39.27	32601280
910	Ubiquitination	KRLKGAFKAVMTSIK HHHHHHHHHHHHHHH	39.27	-
917	2-Hydroxyisobutyrylation	KAVMTSIKQLSSEEL HHHHHHHHHCCHHHH	44.98	-
917	Acetylation	KAVMTSIKQLSSEEL HHHHHHHHHCCHHHH	44.98	23236377
917	Ubiquitination	KAVMTSIKQLSSEEL HHHHHHHHHCCHHHH	44.98	21890473
920	Phosphorylation	MTSIKQLSSEELEQF HHHHHHCCHHHHHHH	32.96	30624053
921	Phosphorylation	TSIKQLSSEELEQFQ HHHHHCCHHHHHHHH	43.62	28348404
929	Ubiquitination	EELEQFQKTGTIVVE HHHHHHHHHCEEEEE	50.65	21906983
980	Phosphorylation	LDVTPDQSMVDEGMA EECCCCHHHCCHHHH	28.31	24275569
999	Ubiquitination	NRIQKLRKKCNLVPT HHHHHHHHHCCCCCC	72.60	-
1000	Malonylation	RIQKLRKKCNLVPTD HHHHHHHHCCCCCCC	23.17	32601280
1000	Ubiquitination	RIQKLRKKCNLVPTD HHHHHHHHCCCCCCC	23.17	-
1006	Phosphorylation	KKCNLVPTDEITVYY HHCCCCCCCCEEEEE	38.49	28152594
1010	Phosphorylation	LVPTDEITVYYKAKS CCCCCCEEEEEEECC	10.62	28152594
1012	Phosphorylation	PTDEITVYYKAKSEG CCCCEEEEEEECCCC	7.21	28152594
1013	Phosphorylation	TDEITVYYKAKSEGT CCCEEEEEEECCCCC	10.51	28152594
1014	Methylation	DEITVYYKAKSEGTY CCEEEEEEECCCCCC	31.48	115971285
1014	Ubiquitination	DEITVYYKAKSEGTY CCEEEEEEECCCCCC	31.48	-
1042	Acetylation	TTIKAPLKPYPVSPS EEECCCCCCCCCCHH	41.25	26051181
1042	Ubiquitination	TTIKAPLKPYPVSPS EEECCCCCCCCCCHH	41.25	21906983
1044	Phosphorylation	IKAPLKPYPVSPSDK ECCCCCCCCCCHHHC	18.06	30266825
1047	Phosphorylation	PLKPYPVSPSDKVLI CCCCCCCCHHHCEEE	17.74	29255136
1049	Phosphorylation	KPYPVSPSDKVLIQE CCCCCCHHHCEEEEE	42.42	29255136
1051	2-Hydroxyisobutyrylation	YPVSPSDKVLIQEKT CCCCHHHCEEEEECC	43.19	-
1051	Acetylation	YPVSPSDKVLIQEKT CCCCHHHCEEEEECC	43.19	23954790
1051	Malonylation	YPVSPSDKVLIQEKT CCCCHHHCEEEEECC	43.19	26320211
1051	Phosphorylation	YPVSPSDKVLIQEKT CCCCHHHCEEEEECC	43.19	18669648
1051	Ubiquitination	YPVSPSDKVLIQEKT CCCCHHHCEEEEECC	43.19	21890473
1053	Phosphorylation	VSPSDKVLIQEKTQL CCHHHCEEEEECCCC	4.05	18669648
1057	2-Hydroxyisobutyrylation	DKVLIQEKTQLKGSE HCEEEEECCCCCCCE	25.79	-
1057	Acetylation	DKVLIQEKTQLKGSE HCEEEEECCCCCCCE	25.79	26822725
1057	Malonylation	DKVLIQEKTQLKGSE HCEEEEECCCCCCCE	25.79	26320211
1057	Ubiquitination	DKVLIQEKTQLKGSE HCEEEEECCCCCCCE	25.79	-
1058	Phosphorylation	KVLIQEKTQLKGSEL CEEEEECCCCCCCEE	38.08	7721108
1061	Acetylation	IQEKTQLKGSELEIT EEECCCCCCCEEEEE	51.04	26051181
1061	Malonylation	IQEKTQLKGSELEIT EEECCCCCCCEEEEE	51.04	26320211
1061	Ubiquitination	IQEKTQLKGSELEIT EEECCCCCCCEEEEE	51.04	-
1063	Phosphorylation	EKTQLKGSELEITLT ECCCCCCCEEEEEEE	37.10	20860994
1068	Phosphorylation	KGSELEITLTRGSSL CCCEEEEEEECCCCC	16.83	20860994
1113	2-Hydroxyisobutyrylation	DNRLDLLKLKSVVTS CCCHHHHHHHHHHHH	62.25	-
1113	Ubiquitination	DNRLDLLKLKSVVTS CCCHHHHHHHHHHHH	62.25	-
1115	Ubiquitination	RLDLLKLKSVVTSIF CHHHHHHHHHHHHHH	39.35	21906983
1116	Phosphorylation	LDLLKLKSVVTSIFG HHHHHHHHHHHHHHC	32.05	21712546
1120	Phosphorylation	KLKSVVTSIFGVKNT HHHHHHHHHHCCCCC	12.33	21712546
1146	Phosphorylation	QNQTDLLSLSGKTLC CCHHHHHHCCCCEEE	27.99	-
1148	Phosphorylation	QTDLLSLSGKTLCVT HHHHHHCCCCEEEEE	34.56	-
1234	Phosphorylation	LFLNETQTQEITEDI EECCCCCCCCCCCCC	35.27	-
1238	Phosphorylation	ETQTQEITEDIPVKT CCCCCCCCCCCCCEE	27.18	-
1244	Ubiquitination	ITEDIPVKTLNMKTV CCCCCCCEECCCEEE	41.77	2190698
1249	Ubiquitination	PVKTLNMKTVYVSVL CCEECCCEEEEEEEC	33.49	-
1250	Phosphorylation	VKTLNMKTVYVSVLP CEECCCEEEEEEECC	13.29	-
1252	Phosphorylation	TLNMKTVYVSVLPTT ECCCEEEEEEECCCC	7.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYIC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYIC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYIC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GARS_HUMAN	GARS	physical	8816763
SYEP_HUMAN	EPRS	physical	9556618
A4_HUMAN	APP	physical	21832049
SYK_HUMAN	KARS	physical	22939629
SYLC_HUMAN	LARS	physical	22939629
SYQ_HUMAN	QARS	physical	22939629
SYRC_HUMAN	RARS	physical	22939629
SYMC_HUMAN	MARS	physical	22939629
SYNC_HUMAN	NARS	physical	22939629
TCPE_HUMAN	CCT5	physical	22939629
TLN1_HUMAN	TLN1	physical	22939629
UBA1_HUMAN	UBA1	physical	22939629
TRM1_HUMAN	TRMT1	physical	22939629
TXLNA_HUMAN	TXLNA	physical	22939629
AIMP1_HUMAN	AIMP1	physical	22863883
HNRL2_HUMAN	HNRNPUL2	physical	22863883
MAP4_HUMAN	MAP4	physical	22863883
RL24_HUMAN	RPL24	physical	22863883
HNRPQ_HUMAN	SYNCRIP	physical	22863883
ACACA_HUMAN	ACACA	physical	26344197
AIMP2_HUMAN	AIMP2	physical	26344197
MCA3_HUMAN	EEF1E1	physical	26344197
SYEP_HUMAN	EPRS	physical	26344197
GFPT1_HUMAN	GFPT1	physical	26344197
SYLC_HUMAN	LARS	physical	26344197
SYQ_HUMAN	QARS	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
OFD1_HUMAN	OFD1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00167: L-Isoleucine

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-1047, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-844, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-1047, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1047, AND MASSSPECTROMETRY.
PubMed: 18669648

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1047, AND MASSSPECTROMETRY.
PubMed: 17924679