| UniProt ID | AIMP2_HUMAN | |
|---|---|---|
| UniProt AC | Q13155 | |
| Protein Name | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | |
| Gene Name | AIMP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 320 | |
| Subcellular Localization | Cytoplasm, cytosol . Nucleus . Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. | |
| Protein Description | Required for assembly and stability of the aminoacyl-tRNA synthase complex. [PubMed: 19131329 Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.] | |
| Protein Sequence | MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MPMYQVKPYHG ----CCCEECCCCCC | 12.32 | 20068231 | |
| 7 | Ubiquitination | -MPMYQVKPYHGGGA -CCCEECCCCCCCCC | 25.08 | 21890473 | |
| 7 | Ubiquitination | -MPMYQVKPYHGGGA -CCCEECCCCCCCCC | 25.08 | - | |
| 9 | Phosphorylation | PMYQVKPYHGGGAPL CCEECCCCCCCCCCC | 13.84 | 29496907 | |
| 17 | Methylation | HGGGAPLRVELPTCM CCCCCCCEEECCCCE | 20.85 | 81424315 | |
| 22 | Phosphorylation | PLRVELPTCMYRLPN CCEEECCCCEEECCC | 23.64 | 29978859 | |
| 23 | Glutathionylation | LRVELPTCMYRLPNV CEEECCCCEEECCCC | 1.81 | 22555962 | |
| 25 | Phosphorylation | VELPTCMYRLPNVHG EECCCCEEECCCCCC | 15.90 | 29978859 | |
| 26 | Methylation | ELPTCMYRLPNVHGR ECCCCEEECCCCCCC | 19.45 | 26494351 | |
| 33 | Methylation | RLPNVHGRSYGPAPG ECCCCCCCCCCCCCC | 16.30 | 83445863 | |
| 34 | Phosphorylation | LPNVHGRSYGPAPGA CCCCCCCCCCCCCCC | 38.75 | 28857561 | |
| 35 | Phosphorylation | PNVHGRSYGPAPGAG CCCCCCCCCCCCCCC | 26.26 | 28152594 | |
| 48 | Phosphorylation | AGHVQEESNLSLQAL CCCCCCCCCCCHHHH | 42.17 | 28555341 | |
| 51 | Phosphorylation | VQEESNLSLQALESR CCCCCCCCHHHHHHC | 23.76 | 28555341 | |
| 64 | Ubiquitination | SRQDDILKRLYELKA HCHHHHHHHHHHHHH | 40.46 | - | |
| 67 | Phosphorylation | DDILKRLYELKAAVD HHHHHHHHHHHHHHH | 24.21 | 20068231 | |
| 70 | 2-Hydroxyisobutyrylation | LKRLYELKAAVDGLS HHHHHHHHHHHHHHH | 23.51 | - | |
| 70 | Ubiquitination | LKRLYELKAAVDGLS HHHHHHHHHHHHHHH | 23.51 | - | |
| 77 | Phosphorylation | KAAVDGLSKMIQTPD HHHHHHHHHHCCCCC | 26.21 | 20068231 | |
| 82 | Phosphorylation | GLSKMIQTPDADLDV HHHHHCCCCCCCCCC | 16.53 | 26657352 | |
| 90 | Phosphorylation | PDADLDVTNIIQADE CCCCCCCCCEEECCC | 21.99 | 28450419 | |
| 114 | Ubiquitination | DLNSVLGKDYGALKD HHHHHHCCCCCCCCC | 43.55 | - | |
| 130 | Phosphorylation | VINANPASPPLSLLV EECCCCCCCCHHHHH | 28.45 | 21406692 | |
| 134 | Phosphorylation | NPASPPLSLLVLHRL CCCCCCHHHHHHHHH | 25.98 | 21406692 | |
| 143 | S-nitrosylation | LVLHRLLCEHFRVLS HHHHHHHHHHHHHHC | 4.52 | 19483679 | |
| 143 | S-nitrosocysteine | LVLHRLLCEHFRVLS HHHHHHHHHHHHHHC | 4.52 | - | |
| 154 | Phosphorylation | RVLSTVHTHSSVKSV HHHCCCCCCCCCCCC | 21.08 | - | |
| 156 | Phosphorylation | LSTVHTHSSVKSVPE HCCCCCCCCCCCCCH | 37.67 | - | |
| 157 | Phosphorylation | STVHTHSSVKSVPEN CCCCCCCCCCCCCHH | 26.43 | - | |
| 159 | Ubiquitination | VHTHSSVKSVPENLL CCCCCCCCCCCHHHH | 47.92 | - | |
| 167 | Ubiquitination | SVPENLLKCFGEQNK CCCHHHHHHHHHCCC | 30.59 | - | |
| 174 | Acetylation | KCFGEQNKKQPRQDY HHHHHCCCCCCCHHH | 53.10 | 25953088 | |
| 186 | Phosphorylation | QDYQLGFTLIWKNVP HHHCCCEEEEEECCC | 18.61 | 18491316 | |
| 198 | Acetylation | NVPKTQMKFSIQTMC CCCCCEEEEEEEEEC | 26.58 | 26051181 | |
| 205 | Glutathionylation | KFSIQTMCPIEGEGN EEEEEEECCCCCCCH | 3.31 | 22555962 | |
| 219 | Phosphorylation | NIARFLFSLFGQKHN HHHHHHHHHHCCCCC | 25.57 | 23898821 | |
| 252 | Ubiquitination | KEGSSKEKAAVFRSM CCCCCHHHHHHHHHH | 45.44 | - | |
| 252 | 2-Hydroxyisobutyrylation | KEGSSKEKAAVFRSM CCCCCHHHHHHHHHH | 45.44 | - | |
| 252 | Malonylation | KEGSSKEKAAVFRSM CCCCCHHHHHHHHHH | 45.44 | 26320211 | |
| 252 | Acetylation | KEGSSKEKAAVFRSM CCCCCHHHHHHHHHH | 45.44 | 25953088 | |
| 304 | Methylation | ANVQRWMRSCENLAP HHHHHHHHHCCCCCC | 31.06 | 115480765 | |
| 305 | Phosphorylation | NVQRWMRSCENLAPF HHHHHHHHCCCCCCH | 15.07 | 21712546 | |
| 306 | Glutathionylation | VQRWMRSCENLAPFN HHHHHHHCCCCCCHH | 2.57 | 22555962 | |
| 317 | Ubiquitination | APFNTALKLLK---- CCHHHHHHHHC---- | 49.67 | 21890473 | |
| 317 | Acetylation | APFNTALKLLK---- CCHHHHHHHHC---- | 49.67 | 25953088 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AIMP2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AIMP2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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