NECA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NECA2_HUMAN
• UniProt AC: Q7Z6G3
• Protein Name: N-terminal EF-hand calcium-binding protein 2
• Gene Name: NECAB2
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Subcellular Localization: Cytoplasm . Cell projection, dendrite . Cell projection, axon . Cell membrane . Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytopla
• Protein Description: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation..
• Protein Sequence: MCERAARLCRAGAHRLLREPPQQGRALGGLLRWVGARMGEPRESLAPAAPADPGPASPRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEDLFHTIDSDNTNHVDTKELCDYFVDHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQLRQNHIKPSHSAAQTWCGSPTPASAPNHKLMAMEQGKTLPSATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGVRNCFHITAVRLSDGFTFVIYEFWETEEAWKRHLQSPLCKAFRHVKVDTLSQPEALSRILVPAAWCTVGRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Methylation	ERAARLCRAGAHRLL HHHHHHHHHCHHHHH	40.42	-
11 (in isoform 2)	Phosphorylation	-	20.66	30206219
12 (in isoform 2)	Phosphorylation	-	11.54	30206219
13 (in isoform 2)	Phosphorylation	-	5.44	30206219
14 (in isoform 2)	Phosphorylation	-	21.72	30206219
19 (in isoform 2)	Phosphorylation	-	62.39	30206219
42	Asymmetric dimethylarginine	GARMGEPRESLAPAA HHCCCCCHHHHCCCC	41.66	-
42	Methylation	GARMGEPRESLAPAA HHCCCCCHHHHCCCC	41.66	-
57	Phosphorylation	PADPGPASPRGGTAV CCCCCCCCCCCCEEE	20.47	24076635
218	Phosphorylation	QTWCGSPTPASAPNH HHHCCCCCCCCCCCH	32.93	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NECA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NECA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NECA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CENPO_HUMAN	CENPO	physical	16189514
NTAQ1_HUMAN	WDYHV1	physical	16189514
DGC6L_HUMAN	DGCR6L	physical	16189514
TEX11_HUMAN	TEX11	physical	16189514
GTPBA_HUMAN	GTPBP10	physical	16189514
NECA2_HUMAN	NECAB2	physical	16189514
RCOR3_HUMAN	RCOR3	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
KANL1_HUMAN	KANSL1	physical	16189514
CCD33_HUMAN	CCDC33	physical	16189514
NOC4L_HUMAN	NOC4L	physical	16189514
KDM1A_HUMAN	KDM1A	physical	23455924
NECA2_HUMAN	NECAB2	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
RCOR3_HUMAN	RCOR3	physical	25416956
CC146_HUMAN	CCDC146	physical	25416956
RIC8A_HUMAN	RIC8A	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
CARD9_HUMAN	CARD9	physical	25416956
LENG1_HUMAN	LENG1	physical	25416956
CENPO_HUMAN	CENPO	physical	25416956
GCC1_HUMAN	GCC1	physical	25416956
TTC25_HUMAN	TTC25	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
KLC4_HUMAN	KLC4	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
CC151_HUMAN	CCDC151	physical	25416956
KLC3_HUMAN	KLC3	physical	25416956
CC153_HUMAN	CCDC153	physical	25416956
KANL1_HUMAN	KANSL1	physical	25416956
SRCRL_HUMAN	SSC5D	physical	25416956
CC121_HUMAN	CCDC121	physical	21516116
USBP1_HUMAN	USHBP1	physical	21516116
LNX1_HUMAN	LNX1	physical	21516116
NECA3_HUMAN	NECAB3	physical	28514442
ACBD5_HUMAN	ACBD5	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
GOGA4_HUMAN	GOLGA4	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
DCA10_HUMAN	DCAF10	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.