SRCRL_HUMAN - dbPTM
SRCRL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRCRL_HUMAN
UniProt AC A1L4H1
Protein Name Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Gene Name SSC5D
Organism Homo sapiens (Human).
Sequence Length 1573
Subcellular Localization Secreted. Cytoplasm.
Protein Description Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity)..
Protein Sequence MRVLACLLAALVGIQAVERLRLADGPHGCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRQLGCGGALAAPGGAFFGEGAGPVWLSELACRGNEGQLGLCHHRGWKAHICSHEEDAGVVCAGQRVANSRDDSTSPLDGAPWPGLLLELSPSTEEPLVTHAPRPAGNPQNASRKKSPRPKQAKSTRAPLLTTGAPRQERLRLVSGPHRCAGRLEVWHGGRWGTVCDDGWDLRDAAVACRELGCGGALAAPGGARFGPGAGPVWMDDVGCGGGEQALRDCPRSPWGRSNCDHSEDAGLVCTGPAPRLRLADGPHGCAGRLEVWHGGRWGSVCDDAWDLRDAAVACRELGCGGALAAPGGAFFGEGSGPIILDDLRCRGNETALRFCPARPWGQHDCHHREDAGAVCDGMPLGYVPPTAPTDSNNSTPREAASRPPSTMTSQAPGTAGVSPPPASPTVLWEPGPEAGSPQLRLVAGPSKCSGRLEVWHDQRWGTVCDDSWDMRDSAVVCRELGCGGPQQPDPAAGRFGWGAGPIWLDDVGCVGTEASLSDCPAAPWGKHNCAHNEDVGVTCTGPPGLDSISDPFSWSWIPGLGRDRDAWLPGELATKPSASVTASVLEKTTTKAPGKMPKSTKKWVTKNAKRPTTQPPVMPTTKHSRAQSPPDLTSQTTAALTTEASRRPTSEFTRRPTTEAPQRWTSHTTATLTPQAPRERTTKTMAMLTTQGPQEMTSESTIKSIPQASLEPSAEIPEGSPESPKDPAPSPSVSTTGESGLFRVRLADGPNRCAGRLEVWHAGRWGTVCDDNWDLRDATVACWELGCGKVRPRVGKTHYGPGTGPIWLDDMGCKGSEASLSDCPSGAWGKHNCDHEEDVGLTCTGYTDYDDYPPWTWDPTSREDLAKGTTTAGVPGHTLPWRTTRRPGSSSPAIRRLPDTGSKDGYKLPWTWDTPSGRGLAEGTPTAGKLGPTLGAGTTRSPGSPPTLRVHGDTGSPRKPWPERRPPRPAATRTAPPTPSPGPSASPGPPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPDPASRTNPDLILTSPDFALSTPDSSVVPALTPEPSPTPLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPSPSPHPTTTPDPTMAPDPITTLNPTVTPHFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHPTTTPHPTTTPHPTTTPHPTMTPDPTTTPYPTTTPDPTTTPHPTTPDPSSTPVITTVSLPTSLGTELSSPTLAPTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPRSQSPNLTPPPTHTPHSASDLTVSPDPLLSPTAHPLDHPPLDPLTLGPTPGQSPGPHGPCVAPTPPVRVMACEPPALVELVAAVRDVGGQLQRLTQVVEQERQERQALLLGLTQLVEAARGLGQLGEAVKRLAEMAWTTSMPAPTTTTPEEEERPLRGDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
157O-linked_GlycosylationSTEEPLVTHAPRPAG
CCCCCCCCCCCCCCC		21.72OGP
168N-linked_GlycosylationRPAGNPQNASRKKSP
CCCCCCCCCCCCCCC		40.93UniProtKB CARBOHYD
174PhosphorylationQNASRKKSPRPKQAK
CCCCCCCCCCCCCCC		29.2223312004
189PhosphorylationSTRAPLLTTGAPRQE
CCCCCCCCCCCCHHH		30.7623312004
190PhosphorylationTRAPLLTTGAPRQER
CCCCCCCCCCCHHHH		31.1723312004
376N-linked_GlycosylationDDLRCRGNETALRFC
ECCEECCCCHHHHCC		24.88UniProtKB CARBOHYD
410PhosphorylationCDGMPLGYVPPTAPT
CCCCCCCCCCCCCCC		19.9128555341
414PhosphorylationPLGYVPPTAPTDSNN
CCCCCCCCCCCCCCC		38.9228555341
419PhosphorylationPPTAPTDSNNSTPRE
CCCCCCCCCCCCHHH		40.1528555341
420N-linked_GlycosylationPTAPTDSNNSTPREA
CCCCCCCCCCCHHHH		49.64UniProtKB CARBOHYD
421N-linked_GlycosylationTAPTDSNNSTPREAA
CCCCCCCCCCHHHHH		51.73UniProtKB CARBOHYD
433PhosphorylationEAASRPPSTMTSQAP
HHHCCCCCCCCCCCC		33.2324043423
434PhosphorylationAASRPPSTMTSQAPG
HHCCCCCCCCCCCCC		30.1824043423
436PhosphorylationSRPPSTMTSQAPGTA
CCCCCCCCCCCCCCC		20.1324043423
437PhosphorylationRPPSTMTSQAPGTAG
CCCCCCCCCCCCCCC		17.3324043423
442PhosphorylationMTSQAPGTAGVSPPP
CCCCCCCCCCCCCCC		21.1224043423
446PhosphorylationAPGTAGVSPPPASPT
CCCCCCCCCCCCCCC		30.6724043423
451PhosphorylationGVSPPPASPTVLWEP
CCCCCCCCCCEEECC		27.2022210691
453O-linked_GlycosylationSPPPASPTVLWEPGP
CCCCCCCCEEECCCC		26.24OGP
453PhosphorylationSPPPASPTVLWEPGP
CCCCCCCCEEECCCC		26.2422210691
464PhosphorylationEPGPEAGSPQLRLVA
CCCCCCCCCCEEEEE		19.2724043423
581O-linked_GlycosylationDSISDPFSWSWIPGL
CCCCCCCCCCCCCCC		26.11OGP
693O-linked_GlycosylationTEAPQRWTSHTTATL
CCCCCCCCCCCCCCC		16.9055829675
694O-linked_GlycosylationEAPQRWTSHTTATLT
CCCCCCCCCCCCCCC		16.3355829681
696O-linked_GlycosylationPQRWTSHTTATLTPQ
CCCCCCCCCCCCCCC		20.2155829687
697O-linked_GlycosylationQRWTSHTTATLTPQA
CCCCCCCCCCCCCCC		16.5455829693
699O-linked_GlycosylationWTSHTTATLTPQAPR
CCCCCCCCCCCCCCC		29.1355829699
701O-linked_GlycosylationSHTTATLTPQAPRER
CCCCCCCCCCCCCCC		14.7055829703
717PhosphorylationTKTMAMLTTQGPQEM
CCEEHHHHCCCCCCC		12.1824043423
718PhosphorylationKTMAMLTTQGPQEMT
CEEHHHHCCCCCCCC		27.8024043423
725PhosphorylationTQGPQEMTSESTIKS
CCCCCCCCCHHHHCC		28.7024043423
726PhosphorylationQGPQEMTSESTIKSI
CCCCCCCCHHHHCCC		28.3924043423
728PhosphorylationPQEMTSESTIKSIPQ
CCCCCCHHHHCCCCC		34.8924043423
729PhosphorylationQEMTSESTIKSIPQA
CCCCCHHHHCCCCCC		28.5124043423
758O-linked_GlycosylationSPKDPAPSPSVSTTG
CCCCCCCCCCCCCCC		31.73OGP
760O-linked_GlycosylationKDPAPSPSVSTTGES
CCCCCCCCCCCCCCC		32.79OGP
764O-linked_GlycosylationPSPSVSTTGESGLFR
CCCCCCCCCCCCEEE		31.29OGP
884O-linked_GlycosylationYDDYPPWTWDPTSRE
CCCCCCCCCCCCCHH		26.26OGP
917PhosphorylationRTTRRPGSSSPAIRR
CCCCCCCCCCCCHHC		30.2628122231
918PhosphorylationTTRRPGSSSPAIRRL
CCCCCCCCCCCHHCC		46.3828122231
919PhosphorylationTRRPGSSSPAIRRLP
CCCCCCCCCCHHCCC		21.7624719451
928PhosphorylationAIRRLPDTGSKDGYK
CHHCCCCCCCCCCCC		41.2224719451
930PhosphorylationRRLPDTGSKDGYKLP
HCCCCCCCCCCCCCC		29.6624719451
934PhosphorylationDTGSKDGYKLPWTWD
CCCCCCCCCCCCEEC		21.3429083192
939O-linked_GlycosylationDGYKLPWTWDTPSGR
CCCCCCCEECCCCCC		16.12OGP
939PhosphorylationDGYKLPWTWDTPSGR
CCCCCCCEECCCCCC		16.1229083192
942PhosphorylationKLPWTWDTPSGRGLA
CCCCEECCCCCCCCC		15.7729083192
944PhosphorylationPWTWDTPSGRGLAEG
CCEECCCCCCCCCCC		43.1229083192
961PhosphorylationTAGKLGPTLGAGTTR
CCCCCCCCCCCCCCC		35.7122210691
972PhosphorylationGTTRSPGSPPTLRVH
CCCCCCCCCCEEEEC		30.9622210691
975PhosphorylationRSPGSPPTLRVHGDT
CCCCCCCEEEECCCC		30.4922210691
1002PhosphorylationPRPAATRTAPPTPSP
CCCCCCCCCCCCCCC		38.8828634298
1006PhosphorylationATRTAPPTPSPGPSA
CCCCCCCCCCCCCCC		35.0328634298
1008PhosphorylationRTAPPTPSPGPSASP
CCCCCCCCCCCCCCC		44.9928634298
1012PhosphorylationPTPSPGPSASPGPPG
CCCCCCCCCCCCCCC		47.4928634298
1014PhosphorylationPSPGPSASPGPPGPA
CCCCCCCCCCCCCCC		34.4328634298
1047O-linked_GlycosylationATSDAPDTSPPTPDP
CCCCCCCCCCCCCCC		41.91OGP
1066PhosphorylationNPDLILTSPDFALST
CCCEEECCCCCCCCC		21.0130576142
1073PhosphorylationSPDFALSTPDSSVVP
CCCCCCCCCCCCCCC		31.7830576142
1093PhosphorylationPSPTPLPTLPKELTS
CCCCCCCCCCHHHCC		64.4730576142
1445O-linked_GlycosylationPDPLLSPTAHPLDHP
CCCCCCCCCCCCCCC		33.93OGP
1458O-linked_GlycosylationHPPLDPLTLGPTPGQ
CCCCCCCCCCCCCCC		34.75OGP
1462O-linked_GlycosylationDPLTLGPTPGQSPGP
CCCCCCCCCCCCCCC		37.95OGP
1466O-linked_GlycosylationLGPTPGQSPGPHGPC
CCCCCCCCCCCCCCC		37.43OGP
1558O-linked_GlycosylationTTSMPAPTTTTPEEE
HCCCCCCCCCCCHHH		38.59OGP
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SRCRL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRCRL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRCRL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCC2_HUMANGCC2physical
28514442
RRAS_HUMANRRASphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRCRL_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory