CC121_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC121_HUMAN
• UniProt AC: Q6ZUS5
• Protein Name: Coiled-coil domain-containing protein 121
• Gene Name: CCDC121
• Organism: Homo sapiens (Human).
• Sequence Length: 278
• Protein Sequence: MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MTDLNKHIKQAQTQR CCHHHHHHHHHHHHH	3.65	27251275
8 (in isoform 2)	Phosphorylation	-	3.65	27251275
10	Phosphorylation	DLNKHIKQAQTQRKQ HHHHHHHHHHHHHHH	37.79	27251275
10 (in isoform 2)	Phosphorylation	-	37.79	27251275
15 (in isoform 2)	Phosphorylation	-	31.88	27174698
21 (in isoform 2)	Phosphorylation	-	55.88	27174698
39 (in isoform 2)	Phosphorylation	-	4.59	27499020
60	Phosphorylation	QPEKVWNSYLQKSGE CCHHHHHHHHHHHCH	16.11	29759185
61	Phosphorylation	PEKVWNSYLQKSGEI CHHHHHHHHHHHCHH	15.22	29759185
65	Phosphorylation	WNSYLQKSGEIERRR HHHHHHHHCHHHHHH	28.79	29759185
123	Phosphorylation	KQEKEIQTLQEETKK HHHHHHHHHHHHHHH	35.75	-
128	Phosphorylation	IQTLQEETKKVQAET HHHHHHHHHHHHHHH	35.10	-
150	Ubiquitination	QAQLLQEKRLLEKQL HHHHHHHHHHHHHHC	35.07	29967540
185	Acetylation	QALKLAAKRFIFEYS HHHHHHHHHHHHHHH	42.08	164355
250	Phosphorylation	ARQRLQGSHNQCLNR HHHHHCCCCCCCCCC	13.30	23403867
263	Phosphorylation	NRQDVPKTTPSLPQG CCCCCCCCCCCCCCC	37.56	26270265
264	Phosphorylation	RQDVPKTTPSLPQGT CCCCCCCCCCCCCCC	19.60	26270265
266	Phosphorylation	DVPKTTPSLPQGTKS CCCCCCCCCCCCCCC	51.06	26270265
271	Phosphorylation	TPSLPQGTKSRINPK CCCCCCCCCCCCCCC	22.16	26270265
312	Ubiquitination	----------------------------------------- -----------------------------------------		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC121_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC121_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC121_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
USBP1_HUMAN	USHBP1	physical	25416956
TBC15_HUMAN	TBC1D15	physical	26186194
UB2E3_HUMAN	UBE2E3	physical	26186194
TBC17_HUMAN	TBC1D17	physical	26186194
TBC17_HUMAN	TBC1D17	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442
UB2E3_HUMAN	UBE2E3	physical	28514442
SCRN1_HUMAN	SCRN1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.