SCRN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCRN1_HUMAN
• UniProt AC: Q12765
• Protein Name: Secernin-1
• Gene Name: SCRN1
• Organism: Homo sapiens (Human).
• Sequence Length: 414
• Subcellular Localization: Cytoplasm.
• Protein Description: Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity)..
• Protein Sequence: MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAPPSYC ------CCCCCCCEE	16.60	22223895
18	Ubiquitination	VAFPPRAKDGLVVFG EECCCCCCCCEEEEC	54.32	-
51	Ubiquitination	ADHEPESKVECTYIS CCCCCCCCCEEEEEE	40.15	-
110	Sulfoxidation	EIEALLGMDLVRLGL HHHHHHCCCHHHHCC	3.48	30846556
157	Phosphorylation	CHSFQSAYLIVDRDE CCCCCEEEEEECCCH	11.38	24114839
179	Ubiquitination	GKYWAAEKVTEGVRC HHHHHHHHHHHHHHH	50.13	21906983
189	Phosphorylation	EGVRCICSQLSLTTK HHHHHHHHHCCCCCC	17.78	30108239
192	Phosphorylation	RCICSQLSLTTKMDA HHHHHHCCCCCCCCC	18.94	30108239
194	Phosphorylation	ICSQLSLTTKMDAEH HHHHCCCCCCCCCCC	22.46	30108239
195	Phosphorylation	CSQLSLTTKMDAEHP HHHCCCCCCCCCCCH	29.66	30108239
197	Sulfoxidation	QLSLTTKMDAEHPEL HCCCCCCCCCCCHHH	5.76	21406390
241	Phosphorylation	DCGAGKDSLEKQEES CCCCCHHHHHHHHHH	41.75	21712546
244	Ubiquitination	AGKDSLEKQEESITV CCHHHHHHHHHHHHH	69.20	-
269	Phosphorylation	ASGVCIDSEFFLTTA HCCEEECCCEEEECC	19.18	17929957
275	Phosphorylation	DSEFFLTTASGVSVL CCCEEEECCCCCEEC	22.45	17929957
287	Phosphorylation	SVLPQNRSSPCIHYF EECCCCCCCCCEEEE	46.30	23312004
288	Phosphorylation	VLPQNRSSPCIHYFT ECCCCCCCCCEEEEC	22.13	29214152
295	Phosphorylation	SPCIHYFTGTPDPSR CCCEEEECCCCCCCC	32.74	23312004
297	Phosphorylation	CIHYFTGTPDPSRSI CEEEECCCCCCCCCC	22.81	23312004
301	Phosphorylation	FTGTPDPSRSIFKPF ECCCCCCCCCCCCCE	46.14	23312004
303	Phosphorylation	GTPDPSRSIFKPFIF CCCCCCCCCCCCEEE	36.39	24719451
306	Ubiquitination	DPSRSIFKPFIFVDD CCCCCCCCCEEEECC	37.03	21906983
306	Acetylation	DPSRSIFKPFIFVDD CCCCCCCCCEEEECC	37.03	90427
315	Ubiquitination	FIFVDDVKLVPKTQS EEEECCEEECCCCCC	51.25	-
319	Ubiquitination	DDVKLVPKTQSPCFG CCEEECCCCCCCCCC	52.28	-
320	Phosphorylation	DVKLVPKTQSPCFGD CEEECCCCCCCCCCC	28.36	30108239
322	Phosphorylation	KLVPKTQSPCFGDDD EECCCCCCCCCCCCC	28.94	30108239
324	S-nitrosylation	VPKTQSPCFGDDDPA CCCCCCCCCCCCCHH	7.83	22178444
333	Ubiquitination	GDDDPAKKEPRFQEK CCCCHHHCCCCCCCC	75.06	-
340	Ubiquitination	KEPRFQEKPDRRHEL CCCCCCCCCCHHHHH	41.24	-
349	Ubiquitination	DRRHELYKAHEWARA CHHHHHHHHHHHHHH	56.76	-
360	Phosphorylation	WARAIIESDQEQGRK HHHHHHHCCHHHHHH	33.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCRN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCRN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCRN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAGK_HUMAN	NAGK	physical	22863883
GORS1_HUMAN	GORASP1	physical	25416956
TAB2_HUMAN	TAB2	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
RPA34_HUMAN	CD3EAP	physical	28514442
M3K7_HUMAN	MAP3K7	physical	28514442
CC85C_HUMAN	CCDC85C	physical	28514442
MYCPP_HUMAN	DENND4A	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442
VAPA_HUMAN	VAPA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.