dbPTM

CD81_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CD81_HUMAN
UniProt AC	P60033
Protein Name	CD81 antigen
Gene Name	CD81
Organism	Homo sapiens (Human).
Sequence Length	236
Subcellular Localization	Basolateral cell membrane Multi-pass membrane protein . Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Protein Description	May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell..
Protein Sequence	MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	S-palmitoylation	--MGVEGCTKCIKYL --CCHHHHHHHHHHH	1.76	22560863
8	Ubiquitination	MGVEGCTKCIKYLLF CCHHHHHHHHHHHHH	37.73	18713730
9	S-palmitoylation	GVEGCTKCIKYLLFV CHHHHHHHHHHHHHH	1.42	22560863
11	Ubiquitination	EGCTKCIKYLLFVFN HHHHHHHHHHHHHHH	39.04	18713730
80	S-palmitoylation	MFVGFLGCYGAIQES HHHHHHHHHHHHHHH	2.85	22560863
89	S-palmitoylation	GAIQESQCLLGTFFT HHHHHHHHHHHHHHH	4.76	22560863
97	S-palmitoylation	LLGTFFTCLVILFAC HHHHHHHHHHHHHHH	2.11	22560863
104	S-palmitoylation	CLVILFACEVAAGIW HHHHHHHHHHHHHCH	3.19	22560863
121	Ubiquitination	VNKDQIAKDVKQFYD CCHHHHHHHHHHHHH	65.76	-
124	Ubiquitination	DQIAKDVKQFYDQAL HHHHHHHHHHHHHHH	44.84	21890473
144	Ubiquitination	DDDANNAKAVVKTFH CCCCHHHHHHHHHHH	43.78	21890473
148	Ubiquitination	NNAKAVVKTFHETLD HHHHHHHHHHHHHHC	38.58	21890473
156	S-palmitoylation	TFHETLDCCGSSTLT HHHHHHCCCCHHHHH	2.96	29575903
157	S-palmitoylation	FHETLDCCGSSTLTA HHHHHCCCCHHHHHH	6.22	29575903
161	O-linked_Glycosylation	LDCCGSSTLTALTTS HCCCCHHHHHHHHHH	29.80	OGP
163	O-linked_Glycosylation	CCGSSTLTALTTSVL CCCHHHHHHHHHHHH	21.51	OGP
166	O-linked_Glycosylation	SSTLTALTTSVLKNN HHHHHHHHHHHHHCC	17.98	OGP
167	O-linked_Glycosylation	STLTALTTSVLKNNL HHHHHHHHHHHHCCC	20.07	OGP
168	O-linked_Glycosylation	TLTALTTSVLKNNLC HHHHHHHHHHHCCCC	21.88	OGP
177	O-linked_Glycosylation	LKNNLCPSGSNIISN HHCCCCCCCCHHHHH	54.58	OGP
177	Phosphorylation	LKNNLCPSGSNIISN HHCCCCCCCCHHHHH	54.58	24076635
179	O-linked_Glycosylation	NNLCPSGSNIISNLF CCCCCCCCHHHHHHC	29.23	OGP
179	Phosphorylation	NNLCPSGSNIISNLF CCCCCCCCHHHHHHC	29.23	24076635
183	Phosphorylation	PSGSNIISNLFKEDC CCCCHHHHHHCCHHH	24.55	21712546
187	Ubiquitination	NIISNLFKEDCHQKI HHHHHHCCHHHHHHH	56.67	-
227	S-palmitoylation	MILSMVLCCGIRNSS HHHHHHHHHHHHCCC	1.04	22560863
228	S-palmitoylation	ILSMVLCCGIRNSSV HHHHHHHHHHHCCCC	4.43	22560863

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CD81_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CD81_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CD81_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG5_HUMAN	DLG5	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
KIT_HUMAN	KIT	physical	12036870
CD9_HUMAN	CD9	physical	8630057
MCP_HUMAN	CD46	physical	10741407
TSN4_HUMAN	TSPAN4	physical	9360996
ITA4_HUMAN	ITGA4	physical	10229664
ITB1_HUMAN	ITGB1	physical	10229664
FPRP_HUMAN	PTGFRN	physical	11278880
ITB1_HUMAN	ITGB1	physical	12175627
CD81_HUMAN	CD81	physical	12437138
CD9_HUMAN	CD9	physical	9804823
IFM1_HUMAN	IFITM1	physical	2398277
IGSF8_HUMAN	IGSF8	physical	11673522
FPRP_HUMAN	PTGFRN	physical	11087758
RN128_MOUSE	Rnf128	physical	18713730
FLNA_HUMAN	FLNA	physical	23463506
ACTN1_HUMAN	ACTN1	physical	23463506
ACTN4_HUMAN	ACTN4	physical	23463506
COF1_HUMAN	CFL1	physical	23463506
COF2_HUMAN	CFL2	physical	23463506
CNN2_HUMAN	CNN2	physical	23463506
LASP1_HUMAN	LASP1	physical	23463506
NUCL_HUMAN	NCL	physical	23463506
SAMH1_HUMAN	SAMHD1	physical	23463506
SPB9_HUMAN	SERPINB9	physical	23463506
MIC60_HUMAN	IMMT	physical	23463506
STK10_HUMAN	STK10	physical	23463506
UBXN1_HUMAN	UBXN1	physical	23463506
IBTK_HUMAN	IBTK	physical	23463506
RACK1_HUMAN	GNB2L1	physical	23463506
INP4A_HUMAN	INPP4A	physical	23463506
TCPG_HUMAN	CCT3	physical	23463506
TCPD_HUMAN	CCT4	physical	23463506
H13_HUMAN	HIST1H1D	physical	23463506
H12_HUMAN	HIST1H1C	physical	23463506
H14_HUMAN	HIST1H1E	physical	23463506
H2B1D_HUMAN	HIST1H2BD	physical	23463506
H2B1C_HUMAN	HIST1H2BD	physical	23463506
H2B1J_HUMAN	HIST1H2BJ	physical	23463506
H2B1K_HUMAN	HIST1H2BK	physical	23463506
H2B1H_HUMAN	HIST1H2BH	physical	23463506
H2B1O_HUMAN	HIST1H2BO	physical	23463506
H2B1L_HUMAN	HIST1H2BL	physical	23463506
H2B1M_HUMAN	HIST1H2BM	physical	23463506
H2B1N_HUMAN	HIST1H2BN	physical	23463506
H11_HUMAN	HIST1H1A	physical	23463506
H2B1B_HUMAN	HIST1H2BB	physical	23463506
H2B2F_HUMAN	HIST2H2BF	physical	23463506
H31T_HUMAN	HIST3H3	physical	23463506
H32_HUMAN	HIST2H3C	physical	23463506
RBBP4_HUMAN	RBBP4	physical	23463506
H2B1A_HUMAN	HIST1H2BA	physical	23463506
G3P_HUMAN	GAPDH	physical	23463506
KPYM_HUMAN	PKM	physical	23463506
PFKAP_HUMAN	PFKP	physical	23463506
PDIA6_HUMAN	PDIA6	physical	23463506
ATPA_HUMAN	ATP5A1	physical	23463506
C1TC_HUMAN	MTHFD1	physical	23463506
ATPO_HUMAN	ATP5O	physical	23463506
NAMPT_HUMAN	NAMPT	physical	23463506
EIF3A_HUMAN	EIF3A	physical	23463506
DDX17_HUMAN	DDX17	physical	23463506
HNRPU_HUMAN	HNRNPU	physical	23463506
HNRPQ_HUMAN	SYNCRIP	physical	23463506
EF1A1_HUMAN	EEF1A1	physical	23463506
SFPQ_HUMAN	SFPQ	physical	23463506
EIF3L_HUMAN	EIF3L	physical	23463506
PABP1_HUMAN	PABPC1	physical	23463506
EIF3B_HUMAN	EIF3B	physical	23463506
EIF3C_HUMAN	EIF3C	physical	23463506
EIFCL_HUMAN	EIF3CL	physical	23463506
SP16H_HUMAN	SUPT16H	physical	23463506
ROA2_HUMAN	HNRNPA2B1	physical	23463506
DHX15_HUMAN	DHX15	physical	23463506
ROA1_HUMAN	HNRNPA1	physical	23463506
NONO_HUMAN	NONO	physical	23463506
SET_HUMAN	SET	physical	23463506
EIF3F_HUMAN	EIF3F	physical	23463506
HNRPK_HUMAN	HNRNPK	physical	23463506
NPM_HUMAN	NPM1	physical	23463506
EIF3E_HUMAN	EIF3E	physical	23463506
HNRH1_HUMAN	HNRNPH1	physical	23463506
DDX3X_HUMAN	DDX3X	physical	23463506
DDX5_HUMAN	DDX5	physical	23463506
MCM5_HUMAN	MCM5	physical	23463506
AN32B_HUMAN	ANP32B	physical	23463506
EF1A2_HUMAN	EEF1A2	physical	23463506
PAIRB_HUMAN	SERBP1	physical	23463506
EIF3I_HUMAN	EIF3I	physical	23463506
HNRPD_HUMAN	HNRNPD	physical	23463506
ROA3_HUMAN	HNRNPA3	physical	23463506
SMD3_HUMAN	SNRPD3	physical	23463506
PDCD4_HUMAN	PDCD4	physical	23463506
EIF3H_HUMAN	EIF3H	physical	23463506
EWS_HUMAN	EWSR1	physical	23463506
SMD1_HUMAN	SNRPD1	physical	23463506
SRSF3_HUMAN	SRSF3	physical	23463506
EF1D_HUMAN	EEF1D	physical	23463506
HNRPM_HUMAN	HNRNPM	physical	23463506
DDX3Y_HUMAN	DDX3Y	physical	23463506
CPSF6_HUMAN	CPSF6	physical	23463506
EFTU_HUMAN	TUFM	physical	23463506
LRC47_HUMAN	LRRC47	physical	23463506
RSMB_HUMAN	SNRPB	physical	23463506
THOC4_HUMAN	ALYREF	physical	23463506
CPSF5_HUMAN	NUDT21	physical	23463506
EIF3G_HUMAN	EIF3G	physical	23463506
EIF3K_HUMAN	EIF3K	physical	23463506
KHDR1_HUMAN	KHDRBS1	physical	23463506
FUBP2_HUMAN	KHSRP	physical	23463506
LC7L2_HUMAN	LUC7L2	physical	23463506
SF3B3_HUMAN	SF3B3	physical	23463506
IF4A1_HUMAN	EIF4A1	physical	23463506
CRIP1_HUMAN	CRIP1	physical	23463506
FUBP1_HUMAN	FUBP1	physical	23463506
PCBP1_HUMAN	PCBP1	physical	23463506
PCBP2_HUMAN	PCBP2	physical	23463506
RTF1_HUMAN	RTF1	physical	23463506
SRSF8_HUMAN	SRSF8	physical	23463506
IF4A2_HUMAN	EIF4A2	physical	23463506
SYWC_HUMAN	WARS	physical	23463506
RU1C_HUMAN	SNRPC	physical	23463506
RAC2_HUMAN	RAC2	physical	23463506
PKN1_HUMAN	PKN1	physical	23463506
LAP2A_HUMAN	TMPO	physical	23463506
LAP2B_HUMAN	TMPO	physical	23463506
TBB5_HUMAN	TUBB	physical	23463506
TBB4B_HUMAN	TUBB4B	physical	23463506
TBA1A_HUMAN	TUBA1A	physical	23463506
TBA1B_HUMAN	TUBA1B	physical	23463506
TBB2B_HUMAN	TUBB2B	physical	23463506
TBB2A_HUMAN	TUBB2A	physical	23463506
TBB3_HUMAN	TUBB3	physical	23463506
TBB4A_HUMAN	TUBB4A	physical	23463506
TBA1C_HUMAN	TUBA1C	physical	23463506
TBA3C_HUMAN	TUBA3C	physical	23463506
TBA3E_HUMAN	TUBA3E	physical	23463506
TBA4A_HUMAN	TUBA4A	physical	23463506
TBB6_HUMAN	TUBB6	physical	23463506
TBE_HUMAN	TUBE1	physical	23463506
FA98B_HUMAN	FAM98B	physical	23463506
RS4X_HUMAN	RPS4X	physical	23463506
RS9_HUMAN	RPS9	physical	23463506
RS18_HUMAN	RPS18	physical	23463506
RS19_HUMAN	RPS19	physical	23463506
RLA0_HUMAN	RPLP0	physical	23463506
RS3_HUMAN	RPS3	physical	23463506
RL12_HUMAN	RPL12	physical	23463506
RL6_HUMAN	RPL6	physical	23463506
RS25_HUMAN	RPS25	physical	23463506
RS8_HUMAN	RPS8	physical	23463506
RLA2_HUMAN	RPLP2	physical	23463506
RS16_HUMAN	RPS16	physical	23463506
RS2_HUMAN	RPS2	physical	23463506
RS3A_HUMAN	RPS3A	physical	23463506
RL4_HUMAN	RPL4	physical	23463506
RL22_HUMAN	RPL22	physical	23463506
RL27_HUMAN	RPL27	physical	23463506
RS13_HUMAN	RPS13	physical	23463506
RS4Y1_HUMAN	RPS4Y1	physical	23463506
RS14_HUMAN	RPS14	physical	23463506
RL5_HUMAN	RPL5	physical	23463506
RL23A_HUMAN	RPL23A	physical	23463506
RL27A_HUMAN	RPL27A	physical	23463506
RL31_HUMAN	RPL31	physical	23463506
RS6_HUMAN	RPS6	physical	23463506
RL11_HUMAN	RPL11	physical	23463506
UBIM_HUMAN	FAU	physical	23463506
RL13_HUMAN	RPL13	physical	23463506
RL17_HUMAN	RPL17	physical	23463506
RL35_HUMAN	RPL35	physical	23463506
RS15_HUMAN	RPS15	physical	23463506
RS23_HUMAN	RPS23	physical	23463506
RL24_HUMAN	RPL24	physical	23463506
RS28_HUMAN	RPS28	physical	23463506
CSK2B_HUMAN	CSNK2B	physical	21988832
JAK3_HUMAN	JAK3	physical	21988832
GGT1_HUMAN	GGT1	physical	9862348
CD82_HUMAN	CD82	physical	9862348
TFR2_HUMAN	TFR2	physical	25635054

Drug and Disease Associations

Kegg Disease
H00088	Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell cos
OMIM Disease
613496	Immunodeficiency, common variable, 6 (CVID6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CD81_HUMAN

Related Literatures of Post-Translational Modification