TSN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSN4_HUMAN
• UniProt AC: O14817
• Protein Name: Tetraspanin-4
• Gene Name: TSPAN4
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Sequence: MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQVVKADTYCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Acetylation	RYAQQDLKKGLHLYG HHHHHHHHHCCEEEE	53.75	27452117
128	Phosphorylation	KGLHLYGTQGNVGLT HCCEEEECCCCCCCC	21.53	22210691
135	Phosphorylation	TQGNVGLTNAWSIIQ CCCCCCCCCCHHHHH	19.57	22210691
143	Phosphorylation	NAWSIIQTDFRCCGV CCHHHHHCCCCCCCC	27.05	22210691
152	N-linked_Glycosylation	FRCCGVSNYTDWFEV CCCCCCCCCCCHHHH	41.12	UniProtKB CARBOHYD
161	N-linked_Glycosylation	TDWFEVYNATRVPDS CCHHHHHCCCCCCCC	39.76	19159218
168	Phosphorylation	NATRVPDSCCLEFSE CCCCCCCCEEEEEHH	10.72	26307563
174	Phosphorylation	DSCCLEFSESCGLHA CCEEEEEHHHCCCCC	21.16	26307563
176	Phosphorylation	CCLEFSESCGLHAPG EEEEEHHHCCCCCCC	16.58	26307563
184	Phosphorylation	CGLHAPGTWWKAPCY CCCCCCCCCCCCCCH	27.39	26307563
191	Phosphorylation	TWWKAPCYETVKVWL CCCCCCCHHHHHHHH	17.36	26307563
193	Phosphorylation	WKAPCYETVKVWLQE CCCCCHHHHHHHHHH	10.11	26307563
228	S-palmitoylation	TFAMTMYCQVVKADT HHHHHHHHHHHCCCC	1.39	29575903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD9_HUMAN	CD9	physical	9360996
CD81_HUMAN	CD81	physical	9360996
ITA3_HUMAN	ITGA3	physical	9360996
ITA6_HUMAN	ITGA6	physical	9360996
ITB1_HUMAN	ITGB1	physical	9360996
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-161, AND MASSSPECTROMETRY.
PubMed: 19159218