ITA6_HUMAN - dbPTM
ITA6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITA6_HUMAN
UniProt AC P23229
Protein Name Integrin alpha-6
Gene Name ITGA6
Organism Homo sapiens (Human).
Sequence Length 1130
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Cell membrane
Lipid-anchor .
Protein Description Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. [PubMed: 20682778 ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling]
Protein Sequence MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNENESYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationAGQLCLLYLSAGLLS
HHHHHHHHHHHHHHH
5.9024043423
13PhosphorylationQLCLLYLSAGLLSRL
HHHHHHHHHHHHHHH
13.5122817900
18PhosphorylationYLSAGLLSRLGAAFN
HHHHHHHHHHHHHCC
30.4224043423
28PhosphorylationGAAFNLDTREDNVIR
HHHCCCCCCCCCHHH
38.8424043423
78N-linked_GlycosylationALPLQRANRTGGLYS
CCCCCCCCCCCCEEE
44.21UniProtKB CARBOHYD
84PhosphorylationANRTGGLYSCDITAR
CCCCCCEEECEEEEC
15.5528152594
85PhosphorylationNRTGGLYSCDITARG
CCCCCEEECEEEECC
15.4528152594
86S-nitrosocysteineRTGGLYSCDITARGP
CCCCEEECEEEECCC
2.50-
86S-nitrosylationRTGGLYSCDITARGP
CCCCEEECEEEECCC
2.5022178444
89PhosphorylationGLYSCDITARGPCTR
CEEECEEEECCCEEE
9.3228152594
110UbiquitinationADPTSESKEDQWMGV
CCCCCCCCCCCEEEE
62.3521906983
110 (in isoform 1)Ubiquitination-62.3521906983
110 (in isoform 2)Ubiquitination-62.3521906983
110 (in isoform 3)Ubiquitination-62.3521906983
110 (in isoform 4)Ubiquitination-62.3521906983
110 (in isoform 5)Ubiquitination-62.3521906983
110 (in isoform 6)Ubiquitination-62.3521906983
110 (in isoform 9)Ubiquitination-62.3521906983
131S-nitrosocysteinePGGKVVTCAHRYEKR
CCCEEEEECCHHHHH
1.71-
131S-nitrosylationPGGKVVTCAHRYEKR
CCCEEEEECCHHHHH
1.7122178444
152 (in isoform 7)Ubiquitination-21.0521906983
184UbiquitinationGRLRGHEKFGSCQQG
CCCCCCCCCCCCCCC
49.72-
187PhosphorylationRGHEKFGSCQQGVAA
CCCCCCCCCCCCEEE
16.3422817900
202PhosphorylationTFTKDFHYIVFGAPG
EEECCEEEEEECCCC
9.97-
223N-linked_GlycosylationIVRVEQKNNTFFDMN
EEEEEEECCEEEEEE
53.09UniProtKB CARBOHYD
266 (in isoform 4)Ubiquitination-4.2321906983
266 (in isoform 5)Ubiquitination-4.2321906983
271 (in isoform 2)Ubiquitination-29.5121906983
271 (in isoform 3)Ubiquitination-29.5121906983
278PhosphorylationPDQFVYKTRPPREQP
HHHCCCCCCCCCCCC
30.6225106551
300PhosphorylationMNSYLGFSLDSGKGI
HHCCCCEECCCCCCC
29.4823532336
309PhosphorylationDSGKGIVSKDEITFV
CCCCCCCCCCEEEEE
32.2523532336
310UbiquitinationSGKGIVSKDEITFVS
CCCCCCCCCEEEEEC
48.7821906983
310 (in isoform 1)Ubiquitination-48.7821906983
310 (in isoform 6)Ubiquitination-48.7821906983
310 (in isoform 9)Ubiquitination-48.7821906983
317PhosphorylationKDEITFVSGAPRANH
CCEEEEECCCCCCCC
25.6622817900
323N-linked_GlycosylationVSGAPRANHSGAVVL
ECCCCCCCCCCCEEE
31.0116263699
379PhosphorylationIVIGAPQYFDRDGEV
EEEECCEEECCCCCC
13.34-
409N-linked_GlycosylationNVKPIRLNGTKDSMF
CCCEEECCCCCCCCC
46.36UniProtKB CARBOHYD
446PhosphorylationPYDDLGKVFIYHGSA
CCCCCCCEEEEECCC
3.1520068231
459UbiquitinationSANGINTKPTQVLKG
CCCCCCCCCCCCCCC
41.39-
460PhosphorylationANGINTKPTQVLKGI
CCCCCCCCCCCCCCC
26.4820068231
485PhosphorylationNMDLDRNSYPDVAVG
CCCCCCCCCCCEEEE
38.6520068231
486PhosphorylationMDLDRNSYPDVAVGS
CCCCCCCCCCEEEEE
13.6530387612
493PhosphorylationYPDVAVGSLSDSVTI
CCCEEEEECCCCEEE
20.3620068231
495PhosphorylationDVAVGSLSDSVTIFR
CEEEEECCCCEEEEC
29.5430387612
497PhosphorylationAVGSLSDSVTIFRSR
EEEECCCCEEEECCC
20.1320068231
499PhosphorylationGSLSDSVTIFRSRPV
EECCCCEEEECCCCE
20.5330387612
512PhosphorylationPVINIQKTITVTPNR
CEEEEEEEEEECCCC
12.9022817900
525UbiquitinationNRIDLRQKTACGAPS
CCEECCHHHCCCCCC
31.49-
540UbiquitinationGICLQVKSCFEYTAN
CEEEEEECCEEEECC
25.7823503661
540 (in isoform 7)Ubiquitination-25.7821906983
541S-nitrosocysteineICLQVKSCFEYTANP
EEEEEECCEEEECCC
2.20-
541S-nitrosylationICLQVKSCFEYTANP
EEEEEECCEEEECCC
2.2022178444
545UbiquitinationVKSCFEYTANPAGYN
EECCEEEECCCCCCC
16.8623503661
560PhosphorylationPSISIVGTLEAEKER
CCCEEEEEHHHHHHH
15.5522817900
570PhosphorylationAEKERRKSGLSSRVQ
HHHHHHHCCCCCCEE
43.0627282143
580UbiquitinationSSRVQFRNQGSEPKY
CCCEECCCCCCCCCC
52.4329967540
588PhosphorylationQGSEPKYTQELTLKR
CCCCCCCCCEEECHH
22.9922817900
592PhosphorylationPKYTQELTLKRQKQK
CCCCCEEECHHHHHH
29.4922817900
624PhosphorylationRPIPITASVEIQEPS
CCCCEEEEEEECCCC
16.1922817900
632PhosphorylationVEIQEPSSRRRVNSL
EEECCCCCCCCCCCC
40.2922817900
648PhosphorylationEVLPILNSDEPKTAH
HHHHCCCCCCCCCCE
39.6522817900
654 (in isoform 4)Ubiquitination-12.0821906983
654 (in isoform 5)Ubiquitination-12.0821906983
659UbiquitinationKTAHIDVHFLKEGCG
CCCEEEHHHHHCCCC
20.6923503661
659 (in isoform 2)Ubiquitination-20.6921906983
659 (in isoform 3)Ubiquitination-20.6921906983
669UbiquitinationKEGCGDDNVCNSNLK
HCCCCCCCCCCCCEE
45.0129967540
690UbiquitinationTREGNQDKFSYLPIQ
CCCCCCCCEEECEEC
26.84-
692PhosphorylationEGNQDKFSYLPIQKG
CCCCCCEEECEECCC
31.3423403867
698UbiquitinationFSYLPIQKGVPELVL
EEECEECCCCCCEEE
63.706983
698 (in isoform 1)Ubiquitination-63.7021906983
698 (in isoform 6)Ubiquitination-63.7021906983
698 (in isoform 9)Ubiquitination-63.7021906983
699UbiquitinationSYLPIQKGVPELVLK
EECEECCCCCCEEEC
24.6829967540
716PhosphorylationKDIALEITVTNSPSN
CCEEEEEEEECCCCC
16.3522817900
722PhosphorylationITVTNSPSNPRNPTK
EEEECCCCCCCCCCC
60.3222817900
742PhosphorylationHEAKLIATFPDTLTY
HHHHHHEECCCCCHH
28.80-
750PhosphorylationFPDTLTYSAYRELRA
CCCCCHHHHHHHHHC
17.37-
752PhosphorylationDTLTYSAYRELRAFP
CCCHHHHHHHHHCCC
9.93-
770N-linked_GlycosylationLSCVANQNGSQADCE
HHEEECCCCCCCCCC
52.4717660510
771UbiquitinationSCVANQNGSQADCEL
HEEECCCCCCCCCCC
16.0323503661
772UbiquitinationCVANQNGSQADCELG
EEECCCCCCCCCCCC
29.7323503661
781UbiquitinationADCELGNPFKRNSNV
CCCCCCCCCCCCCCE
34.0523503661
781 (in isoform 7)Ubiquitination-34.0521906983
782UbiquitinationDCELGNPFKRNSNVT
CCCCCCCCCCCCCEE
15.6523503661
786UbiquitinationGNPFKRNSNVTFYLV
CCCCCCCCCEEEEEE
36.3923503661
787N-linked_GlycosylationNPFKRNSNVTFYLVL
CCCCCCCCEEEEEEE
40.16UniProtKB CARBOHYD
787UbiquitinationNPFKRNSNVTFYLVL
CCCCCCCCEEEEEEE
40.1623503661
788UbiquitinationPFKRNSNVTFYLVLS
CCCCCCCEEEEEEEE
3.8229967540
814PhosphorylationDINLKLETTSNQDNL
CEEEEEEECCCCCCC
46.0629083192
815PhosphorylationINLKLETTSNQDNLA
EEEEEEECCCCCCCC
19.1229083192
816PhosphorylationNLKLETTSNQDNLAP
EEEEEECCCCCCCCC
39.6629083192
825PhosphorylationQDNLAPITAKAKVVI
CCCCCCCHHHHHHHH
22.5022817900
871PhosphorylationEVGSLIEYEFRVINL
HHCHHEEEEEEEEEC
17.24-
885UbiquitinationLGKPLTNLGTATLNI
CCCCCCCCCEEEEEE
5.6323503661
886UbiquitinationGKPLTNLGTATLNIQ
CCCCCCCCEEEEEEE
18.5123503661
887PhosphorylationKPLTNLGTATLNIQW
CCCCCCCEEEEEEEC
21.45-
889PhosphorylationLTNLGTATLNIQWPK
CCCCCEEEEEEECCC
21.85-
895 (in isoform 4)Ubiquitination-14.1821906983
895 (in isoform 5)Ubiquitination-14.1821906983
899PhosphorylationIQWPKEISNGKWLLY
EECCCEECCCEEEEE
40.39-
900UbiquitinationQWPKEISNGKWLLYL
ECCCEECCCEEEEEE
62.8223503661
900 (in isoform 2)Ubiquitination-62.8221906983
900 (in isoform 3)Ubiquitination-62.8221906983
901UbiquitinationWPKEISNGKWLLYLV
CCCEECCCEEEEEEE
18.7423503661
902UbiquitinationPKEISNGKWLLYLVK
CCEECCCEEEEEEEE
38.63-
919PhosphorylationSKGLEKVTCEPQKEI
CCCCCEEECCCHHHH
23.4024076635
928PhosphorylationEPQKEINSLNLTESH
CCHHHHCCCCCCCCC
25.0524076635
930N-linked_GlycosylationQKEINSLNLTESHNS
HHHHCCCCCCCCCCH
44.7517660510
931 (in isoform 7)Phosphorylation-7.3428152594
932PhosphorylationEINSLNLTESHNSRK
HHCCCCCCCCCCHHH
34.0829978859
934PhosphorylationNSLNLTESHNSRKKR
CCCCCCCCCCHHHHH
23.8029978859
934 (in isoform 7)Phosphorylation-23.8028152594
935 (in isoform 7)Phosphorylation-30.0128152594
937PhosphorylationNLTESHNSRKKREIT
CCCCCCCHHHHHCCC
39.8029978859
937UbiquitinationNLTESHNSRKKREIT
CCCCCCCHHHHHCCC
39.8033845483
939UbiquitinationTESHNSRKKREITEK
CCCCCHHHHHCCCHH
56.8821906983
939 (in isoform 1)Ubiquitination-56.8821906983
939 (in isoform 6)Ubiquitination-56.8821906983
945 (in isoform 7)Phosphorylation-48.9328355574
947UbiquitinationKREITEKQIDDNRKF
HHCCCHHHCCCCCEE
37.8023503661
947 (in isoform 7)Ubiquitination-37.8021906983
948UbiquitinationREITEKQIDDNRKFS
HCCCHHHCCCCCEEE
12.1523503661
949UbiquitinationEITEKQIDDNRKFSL
CCCHHHCCCCCEEEE
44.6423503661
951 (in isoform 7)Phosphorylation-45.3420639409
952UbiquitinationEKQIDDNRKFSLFAE
HHHCCCCCEEEEEEE
48.6823503661
952 (in isoform 7)Phosphorylation-48.6820639409
954UbiquitinationQIDDNRKFSLFAERK
HCCCCCEEEEEEEEC
7.4821987572
955PhosphorylationIDDNRKFSLFAERKY
CCCCCEEEEEEEECC
26.1323312004
963UbiquitinationLFAERKYQTLNCSVN
EEEEECCCEECEEEE
42.4123503661
964UbiquitinationFAERKYQTLNCSVNV
EEEECCCEECEEEEE
19.4923503661
966N-linked_GlycosylationERKYQTLNCSVNVNC
EECCCEECEEEEEEE
21.2917660510
969UbiquitinationYQTLNCSVNVNCVNI
CCEECEEEEEEEEEE
11.4721987572
986UbiquitinationPLRGLDSKASLILRS
CCCCCCCHHHHHHHH
41.48-
997N-linked_GlycosylationILRSRLWNSTFLEEY
HHHHHHCCHHHHHHH
35.4516263699
1009PhosphorylationEEYSKLNYLDILMRA
HHHHHCCHHHHHHHH
19.04-
1043PhosphorylationVRVTVFPSKTVAQYS
EEEEECCCCHHHHHC
29.5122817900
1045PhosphorylationVTVFPSKTVAQYSGV
EEECCCCHHHHHCCC
25.9722817900
1045 (in isoform 4)Phosphorylation-25.9728152594
1048 (in isoform 4)Phosphorylation-28.7028152594
1049 (in isoform 4)Phosphorylation-9.5428152594
1050 (in isoform 2)Phosphorylation-22.6428152594
1051UbiquitinationKTVAQYSGVPWWIIL
CHHHHHCCCCHHHHH
25.2723503661
1052UbiquitinationTVAQYSGVPWWIILV
HHHHHCCCCHHHHHH
2.7029901268
1053 (in isoform 2)Phosphorylation-24.9828152594
1054 (in isoform 2)Phosphorylation-9.1128152594
1055UbiquitinationQYSGVPWWIILVAIL
HHCCCCHHHHHHHHH
2.1733845483
1056UbiquitinationYSGVPWWIILVAILA
HCCCCHHHHHHHHHH
1.2233845483
1059 (in isoform 4)Phosphorylation-1.8828355574
1061 (in isoform 4)Ubiquitination-1.8021906983
1062UbiquitinationWIILVAILAGILMLA
HHHHHHHHHHHHHHH
2.2933845483
1063UbiquitinationIILVAILAGILMLAL
HHHHHHHHHHHHHHH
9.2533845483
1064 (in isoform 2)Phosphorylation-15.3228355574
1065 (in isoform 4)Phosphorylation-1.3720639409
1066UbiquitinationVAILAGILMLALLVF
HHHHHHHHHHHHHHH
1.9423503661
1066 (in isoform 2)Ubiquitination-1.9421906983
1066 (in isoform 4)Phosphorylation-1.9420639409
1067UbiquitinationAILAGILMLALLVFI
HHHHHHHHHHHHHHH
1.6229901268
1068UbiquitinationILAGILMLALLVFIL
HHHHHHHHHHHHHHH
2.4521987572
1070UbiquitinationAGILMLALLVFILWK
HHHHHHHHHHHHHHH
3.5433845483
1070 (in isoform 2)Phosphorylation-3.5420639409
1071 (in isoform 2)Phosphorylation-2.1620639409
1074 (in isoform 9)Phosphorylation-3.3228152594
1077UbiquitinationLLVFILWKCGFFKRS
HHHHHHHHCCCCCCC
22.4932015554
1077 (in isoform 9)Phosphorylation-22.4928152594
1078S-palmitoylationLVFILWKCGFFKRSR
HHHHHHHCCCCCCCC
3.7722314500
1078UbiquitinationLVFILWKCGFFKRSR
HHHHHHHCCCCCCCC
3.7733845483
1078 (in isoform 9)Phosphorylation-3.7728152594
1083UbiquitinationWKCGFFKRSRYDDSV
HHCCCCCCCCCCCCC
22.6221987572
1088 (in isoform 9)Phosphorylation-42.4728355574
1089PhosphorylationKRSRYDDSVPRYHAV
CCCCCCCCCCCEEEE
30.9927499020
1089 (in isoform 6)Phosphorylation-30.9928152594
1090 (in isoform 9)Ubiquitination-3.9321906983
1092 (in isoform 6)Phosphorylation-33.4428152594
1093 (in isoform 6)Phosphorylation-6.5128152594
1094 (in isoform 9)Phosphorylation-21.0120639409
1095 (in isoform 9)Phosphorylation-5.3720639409
1100AcetylationYHAVRIRKEEREIKD
EEEEECCHHHHCCCC
62.6519828883
1103 (in isoform 6)Phosphorylation-52.6228355574
1105 (in isoform 6)Ubiquitination-9.5021906983
1109 (in isoform 6)Phosphorylation-58.6020639409
1110PhosphorylationREIKDEKYIDNLEKK
HCCCCHHHCHHHHHH
16.0930576142
1110 (in isoform 6)Phosphorylation-16.0920639409
1122UbiquitinationEKKQWITKWNENESY
HHHHHHHCCCCCCCC
33.082190698
1129PhosphorylationKWNENESYS------
CCCCCCCCC------
16.5420736484

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITA6_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1103SPhosphorylation

8360143

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITA6_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GIPC1_HUMANGIPC1physical
11479315
TSN4_HUMANTSPAN4physical
9360996
ITB1_HUMANITGB1physical
9660880
MSS4_HUMANRABIFphysical
10094488
BIN1_HUMANBIN1physical
10094488
A4_HUMANAPPphysical
21832049
LG3BP_HUMANLGALS3BPphysical
24362527

Drug and Disease Associations
Kegg Disease
H00586 Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H
OMIM Disease
226730Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITA6_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997, AND MASSSPECTROMETRY.
"Elucidation of N-glycosylation sites on human platelet proteins: aglycoproteomic approach.";
Lewandrowski U., Moebius J., Walter U., Sickmann A.;
Mol. Cell. Proteomics 5:226-233(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, AND MASSSPECTROMETRY.

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