UniProt ID | ITA6_HUMAN | |
---|---|---|
UniProt AC | P23229 | |
Protein Name | Integrin alpha-6 | |
Gene Name | ITGA6 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1130 | |
Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Cell membrane Lipid-anchor . |
|
Protein Description | Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. [PubMed: 20682778 ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling] | |
Protein Sequence | MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNENESYS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
11 | Phosphorylation | AGQLCLLYLSAGLLS HHHHHHHHHHHHHHH | 5.90 | 24043423 | |
13 | Phosphorylation | QLCLLYLSAGLLSRL HHHHHHHHHHHHHHH | 13.51 | 22817900 | |
18 | Phosphorylation | YLSAGLLSRLGAAFN HHHHHHHHHHHHHCC | 30.42 | 24043423 | |
28 | Phosphorylation | GAAFNLDTREDNVIR HHHCCCCCCCCCHHH | 38.84 | 24043423 | |
78 | N-linked_Glycosylation | ALPLQRANRTGGLYS CCCCCCCCCCCCEEE | 44.21 | UniProtKB CARBOHYD | |
84 | Phosphorylation | ANRTGGLYSCDITAR CCCCCCEEECEEEEC | 15.55 | 28152594 | |
85 | Phosphorylation | NRTGGLYSCDITARG CCCCCEEECEEEECC | 15.45 | 28152594 | |
86 | S-nitrosocysteine | RTGGLYSCDITARGP CCCCEEECEEEECCC | 2.50 | - | |
86 | S-nitrosylation | RTGGLYSCDITARGP CCCCEEECEEEECCC | 2.50 | 22178444 | |
89 | Phosphorylation | GLYSCDITARGPCTR CEEECEEEECCCEEE | 9.32 | 28152594 | |
110 | Ubiquitination | ADPTSESKEDQWMGV CCCCCCCCCCCEEEE | 62.35 | 21906983 | |
110 (in isoform 1) | Ubiquitination | - | 62.35 | 21906983 | |
110 (in isoform 2) | Ubiquitination | - | 62.35 | 21906983 | |
110 (in isoform 3) | Ubiquitination | - | 62.35 | 21906983 | |
110 (in isoform 4) | Ubiquitination | - | 62.35 | 21906983 | |
110 (in isoform 5) | Ubiquitination | - | 62.35 | 21906983 | |
110 (in isoform 6) | Ubiquitination | - | 62.35 | 21906983 | |
110 (in isoform 9) | Ubiquitination | - | 62.35 | 21906983 | |
131 | S-nitrosocysteine | PGGKVVTCAHRYEKR CCCEEEEECCHHHHH | 1.71 | - | |
131 | S-nitrosylation | PGGKVVTCAHRYEKR CCCEEEEECCHHHHH | 1.71 | 22178444 | |
152 (in isoform 7) | Ubiquitination | - | 21.05 | 21906983 | |
184 | Ubiquitination | GRLRGHEKFGSCQQG CCCCCCCCCCCCCCC | 49.72 | - | |
187 | Phosphorylation | RGHEKFGSCQQGVAA CCCCCCCCCCCCEEE | 16.34 | 22817900 | |
202 | Phosphorylation | TFTKDFHYIVFGAPG EEECCEEEEEECCCC | 9.97 | - | |
223 | N-linked_Glycosylation | IVRVEQKNNTFFDMN EEEEEEECCEEEEEE | 53.09 | UniProtKB CARBOHYD | |
266 (in isoform 4) | Ubiquitination | - | 4.23 | 21906983 | |
266 (in isoform 5) | Ubiquitination | - | 4.23 | 21906983 | |
271 (in isoform 2) | Ubiquitination | - | 29.51 | 21906983 | |
271 (in isoform 3) | Ubiquitination | - | 29.51 | 21906983 | |
278 | Phosphorylation | PDQFVYKTRPPREQP HHHCCCCCCCCCCCC | 30.62 | 25106551 | |
300 | Phosphorylation | MNSYLGFSLDSGKGI HHCCCCEECCCCCCC | 29.48 | 23532336 | |
309 | Phosphorylation | DSGKGIVSKDEITFV CCCCCCCCCCEEEEE | 32.25 | 23532336 | |
310 | Ubiquitination | SGKGIVSKDEITFVS CCCCCCCCCEEEEEC | 48.78 | 21906983 | |
310 (in isoform 1) | Ubiquitination | - | 48.78 | 21906983 | |
310 (in isoform 6) | Ubiquitination | - | 48.78 | 21906983 | |
310 (in isoform 9) | Ubiquitination | - | 48.78 | 21906983 | |
317 | Phosphorylation | KDEITFVSGAPRANH CCEEEEECCCCCCCC | 25.66 | 22817900 | |
323 | N-linked_Glycosylation | VSGAPRANHSGAVVL ECCCCCCCCCCCEEE | 31.01 | 16263699 | |
379 | Phosphorylation | IVIGAPQYFDRDGEV EEEECCEEECCCCCC | 13.34 | - | |
409 | N-linked_Glycosylation | NVKPIRLNGTKDSMF CCCEEECCCCCCCCC | 46.36 | UniProtKB CARBOHYD | |
446 | Phosphorylation | PYDDLGKVFIYHGSA CCCCCCCEEEEECCC | 3.15 | 20068231 | |
459 | Ubiquitination | SANGINTKPTQVLKG CCCCCCCCCCCCCCC | 41.39 | - | |
460 | Phosphorylation | ANGINTKPTQVLKGI CCCCCCCCCCCCCCC | 26.48 | 20068231 | |
485 | Phosphorylation | NMDLDRNSYPDVAVG CCCCCCCCCCCEEEE | 38.65 | 20068231 | |
486 | Phosphorylation | MDLDRNSYPDVAVGS CCCCCCCCCCEEEEE | 13.65 | 30387612 | |
493 | Phosphorylation | YPDVAVGSLSDSVTI CCCEEEEECCCCEEE | 20.36 | 20068231 | |
495 | Phosphorylation | DVAVGSLSDSVTIFR CEEEEECCCCEEEEC | 29.54 | 30387612 | |
497 | Phosphorylation | AVGSLSDSVTIFRSR EEEECCCCEEEECCC | 20.13 | 20068231 | |
499 | Phosphorylation | GSLSDSVTIFRSRPV EECCCCEEEECCCCE | 20.53 | 30387612 | |
512 | Phosphorylation | PVINIQKTITVTPNR CEEEEEEEEEECCCC | 12.90 | 22817900 | |
525 | Ubiquitination | NRIDLRQKTACGAPS CCEECCHHHCCCCCC | 31.49 | - | |
540 | Ubiquitination | GICLQVKSCFEYTAN CEEEEEECCEEEECC | 25.78 | 23503661 | |
540 (in isoform 7) | Ubiquitination | - | 25.78 | 21906983 | |
541 | S-nitrosocysteine | ICLQVKSCFEYTANP EEEEEECCEEEECCC | 2.20 | - | |
541 | S-nitrosylation | ICLQVKSCFEYTANP EEEEEECCEEEECCC | 2.20 | 22178444 | |
545 | Ubiquitination | VKSCFEYTANPAGYN EECCEEEECCCCCCC | 16.86 | 23503661 | |
560 | Phosphorylation | PSISIVGTLEAEKER CCCEEEEEHHHHHHH | 15.55 | 22817900 | |
570 | Phosphorylation | AEKERRKSGLSSRVQ HHHHHHHCCCCCCEE | 43.06 | 27282143 | |
580 | Ubiquitination | SSRVQFRNQGSEPKY CCCEECCCCCCCCCC | 52.43 | 29967540 | |
588 | Phosphorylation | QGSEPKYTQELTLKR CCCCCCCCCEEECHH | 22.99 | 22817900 | |
592 | Phosphorylation | PKYTQELTLKRQKQK CCCCCEEECHHHHHH | 29.49 | 22817900 | |
624 | Phosphorylation | RPIPITASVEIQEPS CCCCEEEEEEECCCC | 16.19 | 22817900 | |
632 | Phosphorylation | VEIQEPSSRRRVNSL EEECCCCCCCCCCCC | 40.29 | 22817900 | |
648 | Phosphorylation | EVLPILNSDEPKTAH HHHHCCCCCCCCCCE | 39.65 | 22817900 | |
654 (in isoform 4) | Ubiquitination | - | 12.08 | 21906983 | |
654 (in isoform 5) | Ubiquitination | - | 12.08 | 21906983 | |
659 | Ubiquitination | KTAHIDVHFLKEGCG CCCEEEHHHHHCCCC | 20.69 | 23503661 | |
659 (in isoform 2) | Ubiquitination | - | 20.69 | 21906983 | |
659 (in isoform 3) | Ubiquitination | - | 20.69 | 21906983 | |
669 | Ubiquitination | KEGCGDDNVCNSNLK HCCCCCCCCCCCCEE | 45.01 | 29967540 | |
690 | Ubiquitination | TREGNQDKFSYLPIQ CCCCCCCCEEECEEC | 26.84 | - | |
692 | Phosphorylation | EGNQDKFSYLPIQKG CCCCCCEEECEECCC | 31.34 | 23403867 | |
698 | Ubiquitination | FSYLPIQKGVPELVL EEECEECCCCCCEEE | 63.70 | 6983 | |
698 (in isoform 1) | Ubiquitination | - | 63.70 | 21906983 | |
698 (in isoform 6) | Ubiquitination | - | 63.70 | 21906983 | |
698 (in isoform 9) | Ubiquitination | - | 63.70 | 21906983 | |
699 | Ubiquitination | SYLPIQKGVPELVLK EECEECCCCCCEEEC | 24.68 | 29967540 | |
716 | Phosphorylation | KDIALEITVTNSPSN CCEEEEEEEECCCCC | 16.35 | 22817900 | |
722 | Phosphorylation | ITVTNSPSNPRNPTK EEEECCCCCCCCCCC | 60.32 | 22817900 | |
742 | Phosphorylation | HEAKLIATFPDTLTY HHHHHHEECCCCCHH | 28.80 | - | |
750 | Phosphorylation | FPDTLTYSAYRELRA CCCCCHHHHHHHHHC | 17.37 | - | |
752 | Phosphorylation | DTLTYSAYRELRAFP CCCHHHHHHHHHCCC | 9.93 | - | |
770 | N-linked_Glycosylation | LSCVANQNGSQADCE HHEEECCCCCCCCCC | 52.47 | 17660510 | |
771 | Ubiquitination | SCVANQNGSQADCEL HEEECCCCCCCCCCC | 16.03 | 23503661 | |
772 | Ubiquitination | CVANQNGSQADCELG EEECCCCCCCCCCCC | 29.73 | 23503661 | |
781 | Ubiquitination | ADCELGNPFKRNSNV CCCCCCCCCCCCCCE | 34.05 | 23503661 | |
781 (in isoform 7) | Ubiquitination | - | 34.05 | 21906983 | |
782 | Ubiquitination | DCELGNPFKRNSNVT CCCCCCCCCCCCCEE | 15.65 | 23503661 | |
786 | Ubiquitination | GNPFKRNSNVTFYLV CCCCCCCCCEEEEEE | 36.39 | 23503661 | |
787 | N-linked_Glycosylation | NPFKRNSNVTFYLVL CCCCCCCCEEEEEEE | 40.16 | UniProtKB CARBOHYD | |
787 | Ubiquitination | NPFKRNSNVTFYLVL CCCCCCCCEEEEEEE | 40.16 | 23503661 | |
788 | Ubiquitination | PFKRNSNVTFYLVLS CCCCCCCEEEEEEEE | 3.82 | 29967540 | |
814 | Phosphorylation | DINLKLETTSNQDNL CEEEEEEECCCCCCC | 46.06 | 29083192 | |
815 | Phosphorylation | INLKLETTSNQDNLA EEEEEEECCCCCCCC | 19.12 | 29083192 | |
816 | Phosphorylation | NLKLETTSNQDNLAP EEEEEECCCCCCCCC | 39.66 | 29083192 | |
825 | Phosphorylation | QDNLAPITAKAKVVI CCCCCCCHHHHHHHH | 22.50 | 22817900 | |
871 | Phosphorylation | EVGSLIEYEFRVINL HHCHHEEEEEEEEEC | 17.24 | - | |
885 | Ubiquitination | LGKPLTNLGTATLNI CCCCCCCCCEEEEEE | 5.63 | 23503661 | |
886 | Ubiquitination | GKPLTNLGTATLNIQ CCCCCCCCEEEEEEE | 18.51 | 23503661 | |
887 | Phosphorylation | KPLTNLGTATLNIQW CCCCCCCEEEEEEEC | 21.45 | - | |
889 | Phosphorylation | LTNLGTATLNIQWPK CCCCCEEEEEEECCC | 21.85 | - | |
895 (in isoform 4) | Ubiquitination | - | 14.18 | 21906983 | |
895 (in isoform 5) | Ubiquitination | - | 14.18 | 21906983 | |
899 | Phosphorylation | IQWPKEISNGKWLLY EECCCEECCCEEEEE | 40.39 | - | |
900 | Ubiquitination | QWPKEISNGKWLLYL ECCCEECCCEEEEEE | 62.82 | 23503661 | |
900 (in isoform 2) | Ubiquitination | - | 62.82 | 21906983 | |
900 (in isoform 3) | Ubiquitination | - | 62.82 | 21906983 | |
901 | Ubiquitination | WPKEISNGKWLLYLV CCCEECCCEEEEEEE | 18.74 | 23503661 | |
902 | Ubiquitination | PKEISNGKWLLYLVK CCEECCCEEEEEEEE | 38.63 | - | |
919 | Phosphorylation | SKGLEKVTCEPQKEI CCCCCEEECCCHHHH | 23.40 | 24076635 | |
928 | Phosphorylation | EPQKEINSLNLTESH CCHHHHCCCCCCCCC | 25.05 | 24076635 | |
930 | N-linked_Glycosylation | QKEINSLNLTESHNS HHHHCCCCCCCCCCH | 44.75 | 17660510 | |
931 (in isoform 7) | Phosphorylation | - | 7.34 | 28152594 | |
932 | Phosphorylation | EINSLNLTESHNSRK HHCCCCCCCCCCHHH | 34.08 | 29978859 | |
934 | Phosphorylation | NSLNLTESHNSRKKR CCCCCCCCCCHHHHH | 23.80 | 29978859 | |
934 (in isoform 7) | Phosphorylation | - | 23.80 | 28152594 | |
935 (in isoform 7) | Phosphorylation | - | 30.01 | 28152594 | |
937 | Phosphorylation | NLTESHNSRKKREIT CCCCCCCHHHHHCCC | 39.80 | 29978859 | |
937 | Ubiquitination | NLTESHNSRKKREIT CCCCCCCHHHHHCCC | 39.80 | 33845483 | |
939 | Ubiquitination | TESHNSRKKREITEK CCCCCHHHHHCCCHH | 56.88 | 21906983 | |
939 (in isoform 1) | Ubiquitination | - | 56.88 | 21906983 | |
939 (in isoform 6) | Ubiquitination | - | 56.88 | 21906983 | |
945 (in isoform 7) | Phosphorylation | - | 48.93 | 28355574 | |
947 | Ubiquitination | KREITEKQIDDNRKF HHCCCHHHCCCCCEE | 37.80 | 23503661 | |
947 (in isoform 7) | Ubiquitination | - | 37.80 | 21906983 | |
948 | Ubiquitination | REITEKQIDDNRKFS HCCCHHHCCCCCEEE | 12.15 | 23503661 | |
949 | Ubiquitination | EITEKQIDDNRKFSL CCCHHHCCCCCEEEE | 44.64 | 23503661 | |
951 (in isoform 7) | Phosphorylation | - | 45.34 | 20639409 | |
952 | Ubiquitination | EKQIDDNRKFSLFAE HHHCCCCCEEEEEEE | 48.68 | 23503661 | |
952 (in isoform 7) | Phosphorylation | - | 48.68 | 20639409 | |
954 | Ubiquitination | QIDDNRKFSLFAERK HCCCCCEEEEEEEEC | 7.48 | 21987572 | |
955 | Phosphorylation | IDDNRKFSLFAERKY CCCCCEEEEEEEECC | 26.13 | 23312004 | |
963 | Ubiquitination | LFAERKYQTLNCSVN EEEEECCCEECEEEE | 42.41 | 23503661 | |
964 | Ubiquitination | FAERKYQTLNCSVNV EEEECCCEECEEEEE | 19.49 | 23503661 | |
966 | N-linked_Glycosylation | ERKYQTLNCSVNVNC EECCCEECEEEEEEE | 21.29 | 17660510 | |
969 | Ubiquitination | YQTLNCSVNVNCVNI CCEECEEEEEEEEEE | 11.47 | 21987572 | |
986 | Ubiquitination | PLRGLDSKASLILRS CCCCCCCHHHHHHHH | 41.48 | - | |
997 | N-linked_Glycosylation | ILRSRLWNSTFLEEY HHHHHHCCHHHHHHH | 35.45 | 16263699 | |
1009 | Phosphorylation | EEYSKLNYLDILMRA HHHHHCCHHHHHHHH | 19.04 | - | |
1043 | Phosphorylation | VRVTVFPSKTVAQYS EEEEECCCCHHHHHC | 29.51 | 22817900 | |
1045 | Phosphorylation | VTVFPSKTVAQYSGV EEECCCCHHHHHCCC | 25.97 | 22817900 | |
1045 (in isoform 4) | Phosphorylation | - | 25.97 | 28152594 | |
1048 (in isoform 4) | Phosphorylation | - | 28.70 | 28152594 | |
1049 (in isoform 4) | Phosphorylation | - | 9.54 | 28152594 | |
1050 (in isoform 2) | Phosphorylation | - | 22.64 | 28152594 | |
1051 | Ubiquitination | KTVAQYSGVPWWIIL CHHHHHCCCCHHHHH | 25.27 | 23503661 | |
1052 | Ubiquitination | TVAQYSGVPWWIILV HHHHHCCCCHHHHHH | 2.70 | 29901268 | |
1053 (in isoform 2) | Phosphorylation | - | 24.98 | 28152594 | |
1054 (in isoform 2) | Phosphorylation | - | 9.11 | 28152594 | |
1055 | Ubiquitination | QYSGVPWWIILVAIL HHCCCCHHHHHHHHH | 2.17 | 33845483 | |
1056 | Ubiquitination | YSGVPWWIILVAILA HCCCCHHHHHHHHHH | 1.22 | 33845483 | |
1059 (in isoform 4) | Phosphorylation | - | 1.88 | 28355574 | |
1061 (in isoform 4) | Ubiquitination | - | 1.80 | 21906983 | |
1062 | Ubiquitination | WIILVAILAGILMLA HHHHHHHHHHHHHHH | 2.29 | 33845483 | |
1063 | Ubiquitination | IILVAILAGILMLAL HHHHHHHHHHHHHHH | 9.25 | 33845483 | |
1064 (in isoform 2) | Phosphorylation | - | 15.32 | 28355574 | |
1065 (in isoform 4) | Phosphorylation | - | 1.37 | 20639409 | |
1066 | Ubiquitination | VAILAGILMLALLVF HHHHHHHHHHHHHHH | 1.94 | 23503661 | |
1066 (in isoform 2) | Ubiquitination | - | 1.94 | 21906983 | |
1066 (in isoform 4) | Phosphorylation | - | 1.94 | 20639409 | |
1067 | Ubiquitination | AILAGILMLALLVFI HHHHHHHHHHHHHHH | 1.62 | 29901268 | |
1068 | Ubiquitination | ILAGILMLALLVFIL HHHHHHHHHHHHHHH | 2.45 | 21987572 | |
1070 | Ubiquitination | AGILMLALLVFILWK HHHHHHHHHHHHHHH | 3.54 | 33845483 | |
1070 (in isoform 2) | Phosphorylation | - | 3.54 | 20639409 | |
1071 (in isoform 2) | Phosphorylation | - | 2.16 | 20639409 | |
1074 (in isoform 9) | Phosphorylation | - | 3.32 | 28152594 | |
1077 | Ubiquitination | LLVFILWKCGFFKRS HHHHHHHHCCCCCCC | 22.49 | 32015554 | |
1077 (in isoform 9) | Phosphorylation | - | 22.49 | 28152594 | |
1078 | S-palmitoylation | LVFILWKCGFFKRSR HHHHHHHCCCCCCCC | 3.77 | 22314500 | |
1078 | Ubiquitination | LVFILWKCGFFKRSR HHHHHHHCCCCCCCC | 3.77 | 33845483 | |
1078 (in isoform 9) | Phosphorylation | - | 3.77 | 28152594 | |
1083 | Ubiquitination | WKCGFFKRSRYDDSV HHCCCCCCCCCCCCC | 22.62 | 21987572 | |
1088 (in isoform 9) | Phosphorylation | - | 42.47 | 28355574 | |
1089 | Phosphorylation | KRSRYDDSVPRYHAV CCCCCCCCCCCEEEE | 30.99 | 27499020 | |
1089 (in isoform 6) | Phosphorylation | - | 30.99 | 28152594 | |
1090 (in isoform 9) | Ubiquitination | - | 3.93 | 21906983 | |
1092 (in isoform 6) | Phosphorylation | - | 33.44 | 28152594 | |
1093 (in isoform 6) | Phosphorylation | - | 6.51 | 28152594 | |
1094 (in isoform 9) | Phosphorylation | - | 21.01 | 20639409 | |
1095 (in isoform 9) | Phosphorylation | - | 5.37 | 20639409 | |
1100 | Acetylation | YHAVRIRKEEREIKD EEEEECCHHHHCCCC | 62.65 | 19828883 | |
1103 (in isoform 6) | Phosphorylation | - | 52.62 | 28355574 | |
1105 (in isoform 6) | Ubiquitination | - | 9.50 | 21906983 | |
1109 (in isoform 6) | Phosphorylation | - | 58.60 | 20639409 | |
1110 | Phosphorylation | REIKDEKYIDNLEKK HCCCCHHHCHHHHHH | 16.09 | 30576142 | |
1110 (in isoform 6) | Phosphorylation | - | 16.09 | 20639409 | |
1122 | Ubiquitination | EKKQWITKWNENESY HHHHHHHCCCCCCCC | 33.08 | 2190698 | |
1129 | Phosphorylation | KWNENESYS------ CCCCCCCCC------ | 16.54 | 20736484 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ITA6_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference |
---|---|---|---|---|
1103 | S | Phosphorylation |
| 8360143 |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ITA6_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
GIPC1_HUMAN | GIPC1 | physical | 11479315 | |
TSN4_HUMAN | TSPAN4 | physical | 9360996 | |
ITB1_HUMAN | ITGB1 | physical | 9660880 | |
MSS4_HUMAN | RABIF | physical | 10094488 | |
BIN1_HUMAN | BIN1 | physical | 10094488 | |
A4_HUMAN | APP | physical | 21832049 | |
LG3BP_HUMAN | LGALS3BP | physical | 24362527 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
H00586 | Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H | |||||
OMIM Disease | ||||||
226730 | Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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N-linked Glycosylation | |
Reference | PubMed |
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-997, AND MASSSPECTROMETRY. | |
"Elucidation of N-glycosylation sites on human platelet proteins: aglycoproteomic approach."; Lewandrowski U., Moebius J., Walter U., Sickmann A.; Mol. Cell. Proteomics 5:226-233(2006). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323, AND MASSSPECTROMETRY. |