CD9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD9_HUMAN
• UniProt AC: P21926
• Protein Name: CD9 antigen
• Gene Name: CD9
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion..
• Protein Sequence: MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	S-palmitoylation	PVKGGTKCIKYLLFG CCCCHHHHHHHHHHH	3.05	11959120
52	N-linked_Glycosylation	FEQETNNNNSSFYTG HHHHCCCCCCCCHHH	52.40	UniProtKB CARBOHYD
53	N-linked_Glycosylation	EQETNNNNSSFYTGV HHHCCCCCCCCHHHH	40.95	UniProtKB CARBOHYD
78	S-palmitoylation	MLVGFLGCCGAVQES HHHHHHHHHHHHHHH	1.79	11959120
79	S-palmitoylation	LVGFLGCCGAVQESQ HHHHHHHHHHHHHHH	3.58	11959120
87	S-palmitoylation	GAVQESQCMLGLFFG HHHHHHHHHHHHHHH	3.19	11959120
125	Phosphorylation	IKEVQEFYKDTYNKL HHHHHHHHHHHHHHC	13.75	-
126	Methylation	KEVQEFYKDTYNKLK HHHHHHHHHHHHHCC	49.25	-
126	Ubiquitination	KEVQEFYKDTYNKLK HHHHHHHHHHHHHCC	49.25	21906983
126	Acetylation	KEVQEFYKDTYNKLK HHHHHHHHHHHHHCC	49.25	27452117
131	Ubiquitination	FYKDTYNKLKTKDEP HHHHHHHHCCCCCCC	40.73	21906983
131	2-Hydroxyisobutyrylation	FYKDTYNKLKTKDEP HHHHHHHHCCCCCCC	40.73	-
133	Ubiquitination	KDTYNKLKTKDEPQR HHHHHHCCCCCCCHH	55.95	21906983
135	Ubiquitination	TYNKLKTKDEPQRET HHHHCCCCCCCHHHH	59.51	21906983
167	S-palmitoylation	EQFISDICPKKDVLE HHHHHHHCCCCCHHH	4.92	29575903
170	Ubiquitination	ISDICPKKDVLETFT HHHHCCCCCHHHHHC	37.91	21906983
175	Phosphorylation	PKKDVLETFTVKSCP CCCCHHHHHCCCCCC	22.05	23312004
177	Phosphorylation	KDVLETFTVKSCPDA CCHHHHHCCCCCCHH	34.15	23312004
179	Ubiquitination	VLETFTVKSCPDAIK HHHHHCCCCCCHHHH	43.19	-
186	Ubiquitination	KSCPDAIKEVFDNKF CCCCHHHHHHHCCCC	49.93	-
218	S-palmitoylation	MIFSMILCCAIRRNR HHHHHHHHHHHHHHH	0.73	11959120
219	S-palmitoylation	IFSMILCCAIRRNRE HHHHHHHHHHHHHHC	2.94	11959120

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIT_HUMAN	KIT	physical	12036870
ITB1_HUMAN	ITGB1	physical	8630057
IGSF8_HUMAN	IGSF8	physical	11504738
MCP_HUMAN	CD46	physical	10741407
TSN4_HUMAN	TSPAN4	physical	9360996
FPRP_HUMAN	PTGFRN	physical	11278880
ITB1_HUMAN	ITGB1	physical	12175627
CD53_HUMAN	CD53	physical	11959120
SERPH_HUMAN	SERPINH1	physical	10227388
KPCA_HUMAN	PRKCA	physical	11325968
FPRP_HUMAN	PTGFRN	physical	11087758
FPRP_HUMAN	PTGFRN	physical	23091066

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.