| UniProt ID | IGSF8_HUMAN | |
|---|---|---|
| UniProt AC | Q969P0 | |
| Protein Name | Immunoglobulin superfamily member 8 | |
| Gene Name | IGSF8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 613 | |
| Subcellular Localization |
Cell membrane Single-pass membrane protein. |
|
| Protein Description | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.. | |
| Protein Sequence | MGALRPTLLPPSLPLLLLLMLGMGCWAREVLVPEGPLYRVAGTAVSISCNVTGYEGPAQQNFEWFLYRPEAPDTALGIVSTKDTQFSYAVFKSRVVAGEVQVQRLQGDAVVLKIARLQAQDAGIYECHTPSTDTRYLGSYSGKVELRVLPDVLQVSAAPPGPRGRQAPTSPPRMTVHEGQELALGCLARTSTQKHTHLAVSFGRSVPEAPVGRSTLQEVVGIRSDLAVEAGAPYAERLAAGELRLGKEGTDRYRMVVGGAQAGDAGTYHCTAAEWIQDPDGSWAQIAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPAGRHAAYSVGWEMAPAGAPGPGRLVAQLDTEGVGSLGPGYEGRHIAMEKVASRTYRLRLEAARPGDAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTVYRGETASLLCNISVRGGPPGLRLAASWWVERPEDGELSSVPAQLVGGVGQDGVAELGVRPGGGPVSVELVGPRSHRLRLHSLGPEDEGVYHCAPSAWVQHADYSWYQAGSARSGPVTVYPYMHALDTLFVPLLVGTGVALVTGATVLGTITCCFMKRLRKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | N-linked_Glycosylation | TAVSISCNVTGYEGP EEEEEEEECCCCCCC | 27.82 | UniProtKB CARBOHYD | |
| 113 | Ubiquitination | QGDAVVLKIARLQAQ CCCEEEEEEHHHHHH | 23.78 | 29967540 | |
| 136 | Phosphorylation | TPSTDTRYLGSYSGK CCCCCCCCCEECCCC | 19.94 | - | |
| 143 | Ubiquitination | YLGSYSGKVELRVLP CCEECCCCEEEEECC | 26.96 | - | |
| 169 | O-linked_Glycosylation | PRGRQAPTSPPRMTV CCCCCCCCCCCCEEE | 57.81 | OGP | |
| 175 | O-linked_Glycosylation | PTSPPRMTVHEGQEL CCCCCCEEECCCHHH | 21.71 | OGP | |
| 224 | Phosphorylation | QEVVGIRSDLAVEAG HHHHCCCCCHHHHCC | 34.75 | 20363803 | |
| 234 | Phosphorylation | AVEAGAPYAERLAAG HHHCCCCHHHHHHHC | 22.14 | 20363803 | |
| 327 | N-linked_Glycosylation | EPLELLCNVSGALPP CCHHHHEECCCCCCC | 30.84 | 19159218 | |
| 361 | Ubiquitination | GPGRLVAQLDTEGVG CCCCEEEEEECCCCC | 32.18 | 24816145 | |
| 366 | Ubiquitination | VAQLDTEGVGSLGPG EEEEECCCCCCCCCC | 31.04 | 24816145 | |
| 383 | Ubiquitination | GRHIAMEKVASRTYR CHHHCHHHHHCCEEE | 29.98 | 24816145 | |
| 386 | Phosphorylation | IAMEKVASRTYRLRL HCHHHHHCCEEEEEE | 28.30 | 26437602 | |
| 388 | Phosphorylation | MEKVASRTYRLRLEA HHHHHCCEEEEEEEE | 15.53 | 26437602 | |
| 409 | Ubiquitination | GTYRCLAKAYVRGSG HHHHHEEEEECCCCC | 27.57 | - | |
| 427 | Phosphorylation | REAASARSRPLPVHV HHHHHHHCCCCCEEE | 37.66 | 24719451 | |
| 463 | N-linked_Glycosylation | ETASLLCNISVRGGP CCEEEEEEEEECCCC | 29.55 | 19159218 | |
| 490 | O-linked_Glycosylation | RPEDGELSSVPAQLV CCCCCCCCCCCEEEC | 25.61 | OGP | |
| 518 | Phosphorylation | RPGGGPVSVELVGPR CCCCCCEEEEEECCC | 17.01 | 14702039 | |
| 573 | Phosphorylation | GPVTVYPYMHALDTL CCEEEECCHHHHHHH | 5.48 | 25332170 | |
| 579 | Phosphorylation | PYMHALDTLFVPLLV CCHHHHHHHHHHHHC | 23.97 | 25332170 | |
| 594 | Phosphorylation | GTGVALVTGATVLGT CCCCCCCCCCHHHHH | 23.19 | 25332170 | |
| 604 | S-palmitoylation | TVLGTITCCFMKRLR HHHHHHHHHHHHHHH | 1.17 | 21609323 | |
| 605 | S-palmitoylation | VLGTITCCFMKRLRK HHHHHHHHHHHHHHC | 2.53 | 21609323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IGSF8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IGSF8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IGSF8_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-327 AND ASN-463, AND MASSSPECTROMETRY. | |
